RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000213928	Gene ID	10379	Accession	6131
Symbol	IRF9	Alias	p48;IRF-9;ISGF3;ISGF3G	Full Name	interferon regulatory factor 9
Status	Confidence	Length	6799 bases	Strand	Plus strand
Position	14 : 24161245 - 24168043	RNA binding domain	IRF-3
Summary	This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000514185	IRF-3	PF10401	4.9e-42	1
ENSP00000514109	IRF-3	PF10401	2.1e-41	1
ENSP00000514119	IRF-3	PF10401	2.2e-41	1
ENSP00000514115	IRF-3	PF10401	2.5e-41	1
ENSP00000514118	IRF-3	PF10401	2.6e-41	1
ENSP00000514111	IRF-3	PF10401	2.6e-41	1
ENSP00000514110	IRF-3	PF10401	2.6e-41	1
ENSP00000514132	IRF-3	PF10401	2.6e-41	1
ENSP00000380073	IRF-3	PF10401	2.6e-41	1
ENSP00000514112	IRF-3	PF10401	2.6e-41	1
ENSP00000454095	IRF-3	PF10401	2.7e-41	1
ENSP00000514187	IRF-3	PF10401	2.2e-25	1
ENSP00000453534	IRF-3	PF10401	1.1e-24	1
ENSP00000514108	IRF-3	PF10401	1.7e-24	1
ENSP00000514073	IRF-3	PF10401	1.7e-24	1
ENSP00000514133	IRF-3	PF10401	1.7e-24	1
ENSP00000514071	IRF-3	PF10401	1.8e-24	1
ENSP00000514093	IRF-3	PF10401	3.5e-24	1
ENSP00000514074	IRF-3	PF10401	3.6e-24	1
ENSP00000514116	IRF-3	PF10401	4.1e-08	1
ENSP00000313529	IRF-3	PF10401	4.1e-08	1
ENSP00000514131	IRF-3	PF10401	4.1e-08	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
30940163	Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha.	Claudia Schubert	2019-04-02	Journal of hematology & oncology

Name	Transcript ID	bp	Protein	Translation ID
IRF9-215	ENST00000561415	2091	No protein	-
IRF9-201	ENST00000324076	1304	279aa	ENSP00000313529
IRF9-213	ENST00000561342	1581	50aa	ENSP00000453974
IRF9-208	ENST00000560311	3008	No protein	-
IRF9-231	ENST00000699049	2273	No protein	-
IRF9-232	ENST00000699063	1591	453aa	ENSP00000514108
IRF9-218	ENST00000698997	1761	455aa	ENSP00000514073
IRF9-216	ENST00000698995	1706	464aa	ENSP00000514071
IRF9-217	ENST00000698996	1648	278aa	ENSP00000514072
IRF9-202	ENST00000396864	1626	393aa	ENSP00000380073
IRF9-223	ENST00000699018	3468	No protein	-
IRF9-243	ENST00000699076	1611	389aa	ENSP00000514115
IRF9-220	ENST00000699015	1745	456aa	ENSP00000514093
IRF9-203	ENST00000557894	1513	353aa	ENSP00000453534
IRF9-244	ENST00000699077	1270	277aa	ENSP00000514116
IRF9-251	ENST00000699099	1603	138aa	ENSP00000514128
IRF9-233	ENST00000699064	1510	358aa	ENSP00000514109
IRF9-234	ENST00000699065	3894	No protein	-
IRF9-221	ENST00000699016	1952	No protein	-
IRF9-209	ENST00000560365	1864	No protein	-
IRF9-222	ENST00000699017	2771	No protein	-
IRF9-214	ENST00000561412	2092	No protein	-
IRF9-207	ENST00000560275	1615	402aa	ENSP00000454095
IRF9-252	ENST00000699100	1496	138aa	ENSP00000514129
IRF9-212	ENST00000561009	546	No protein	-
IRF9-245	ENST00000699078	1769	No protein	-
IRF9-235	ENST00000699066	1757	No protein	-
IRF9-205	ENST00000559284	2929	No protein	-
IRF9-219	ENST00000698998	1755	465aa	ENSP00000514074
IRF9-246	ENST00000699079	2033	50aa	ENSP00000514117
IRF9-247	ENST00000699080	3065	No protein	-
IRF9-224	ENST00000699019	3568	No protein	-
IRF9-248	ENST00000699081	1586	391aa	ENSP00000514118
IRF9-236	ENST00000699067	3066	392aa	ENSP00000514110
IRF9-210	ENST00000560542	2732	50aa	ENSP00000514075
IRF9-253	ENST00000699101	2805	50aa	ENSP00000514130
IRF9-254	ENST00000699102	1970	No protein	-
IRF9-249	ENST00000699082	1507	367aa	ENSP00000514119
IRF9-237	ENST00000699068	2588	No protein	-
IRF9-225	ENST00000699020	3291	No protein	-
IRF9-211	ENST00000560852	731	50aa	ENSP00000454078
IRF9-226	ENST00000699021	2172	No protein	-
IRF9-238	ENST00000699069	1756	391aa	ENSP00000514111
IRF9-255	ENST00000699103	2369	No protein	-
IRF9-239	ENST00000699070	4603	No protein	-
IRF9-256	ENST00000699104	1282	279aa	ENSP00000514131
IRF9-240	ENST00000699071	1739	393aa	ENSP00000514112
IRF9-227	ENST00000699022	1932	278aa	ENSP00000514094
IRF9-257	ENST00000699105	1726	392aa	ENSP00000514132
IRF9-258	ENST00000699106	3457	No protein	-
IRF9-250	ENST00000699083	1639	244aa	ENSP00000514120
IRF9-259	ENST00000699107	1822	455aa	ENSP00000514133
IRF9-260	ENST00000699108	1708	138aa	ENSP00000514134
IRF9-261	ENST00000699109	2577	No protein	-
IRF9-206	ENST00000559863	2733	No protein	-
IRF9-228	ENST00000699023	2019	No protein	-
IRF9-264	ENST00000699178	1289	325aa	ENSP00000514183
IRF9-229	ENST00000699024	1827	No protein	-
IRF9-230	ENST00000699025	2955	No protein	-
IRF9-262	ENST00000699110	1618	No protein	-
IRF9-241	ENST00000699072	2593	No protein	-
IRF9-242	ENST00000699073	2094	No protein	-
IRF9-204	ENST00000559229	1003	No protein	-
IRF9-263	ENST00000699111	2254	No protein	-
IRF9-265	ENST00000699179	985	83aa	ENSP00000514184
IRF9-266	ENST00000699180	989	206aa	ENSP00000514185
IRF9-267	ENST00000699181	834	36aa	ENSP00000514186
IRF9-268	ENST00000699182	1639	No protein	-
IRF9-269	ENST00000699183	1995	No protein	-
IRF9-270	ENST00000699184	1101	157aa	ENSP00000514187

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000785	part_of chromatin	1	ISA	Homo_sapiens(9606)	Component
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	2	IBA,ISA	Homo_sapiens(9606)	Function
GO:0002376	involved_in immune system process	1	IBA	Homo_sapiens(9606)	Process
GO:0003700	enables DNA-binding transcription factor activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0006366	involved_in transcription by RNA polymerase II	1	TAS	Homo_sapiens(9606)	Process
GO:0007166	involved_in cell surface receptor signaling pathway	1	TAS	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0051607	involved_in defense response to virus	1	IEA	Homo_sapiens(9606)	Process
GO:0070721	part_of ISGF3 complex	1	IPI	Homo_sapiens(9606)	Component
GO:1990837	enables sequence-specific double-stranded DNA binding	1	IDA	Homo_sapiens(9606)	Function