RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000213923	Gene ID	1454	Accession	2453
Symbol	CSNK1E	Alias	CKIe;HCKIE;CKIepsilon	Full Name	casein kinase 1 epsilon
Status	Confidence	Length	27394 bases	Strand	Minus strand
Position	22 : 38290691 - 38318084	RNA binding domain	N.A.
Summary	The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
18518968	Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest.	Seok Wan Yang	2008-01-01	Genome biology

Name	Transcript ID	bp	Protein	Translation ID
CSNK1E-203	ENST00000396832	2817	416aa	ENSP00000380044
CSNK1E-201	ENST00000359867	2642	416aa	ENSP00000352929
CSNK1E-202	ENST00000366216	1005	119aa	ENSP00000400494
CSNK1E-209	ENST00000431632	763	144aa	ENSP00000403610
CSNK1E-213	ENST00000495232	669	No protein	-
CSNK1E-204	ENST00000403904	1580	416aa	ENSP00000384074
CSNK1E-208	ENST00000431611	814	256aa	ENSP00000412194
CSNK1E-212	ENST00000494610	539	No protein	-
CSNK1E-206	ENST00000413574	1631	336aa	ENSP00000407235
CSNK1E-205	ENST00000405675	2127	311aa	ENSP00000384426
CSNK1E-215	ENST00000612795	3162	385aa	ENSP00000501204
CSNK1E-214	ENST00000498529	381	No protein	-
CSNK1E-210	ENST00000442216	787	168aa	ENSP00000397460
CSNK1E-211	ENST00000451964	873	270aa	ENSP00000403057
CSNK1E-207	ENST00000430335	996	225aa	ENSP00000412335

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0004672	enables protein kinase activity	2	IDA,ISS	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006281	involved_in DNA repair	1	TAS	Homo_sapiens(9606)	Process
GO:0006468	involved_in protein phosphorylation	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0006897	involved_in endocytosis	1	IBA	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	IBA	Homo_sapiens(9606)	Process
GO:0008104	involved_in protein localization	1	IEA	Homo_sapiens(9606)	Process
GO:0018105	involved_in peptidyl-serine phosphorylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0030178	involved_in negative regulation of Wnt signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0030426	located_in growth cone	1	IEA	Homo_sapiens(9606)	Component
GO:0032091	involved_in negative regulation of protein binding	1	IDA	Homo_sapiens(9606)	Process
GO:0032436	involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0032880	involved_in regulation of protein localization	1	IDA	Homo_sapiens(9606)	Process
GO:0032922	involved_in circadian regulation of gene expression	1	ISS	Homo_sapiens(9606)	Process
GO:0042752	involved_in regulation of circadian rhythm	1	ISS	Homo_sapiens(9606)	Process
GO:0043025	located_in neuronal cell body	1	IEA	Homo_sapiens(9606)	Component
GO:0048512	involved_in circadian behavior	1	IEA	Homo_sapiens(9606)	Process
GO:0060070	involved_in canonical Wnt signaling pathway	3	IDA,IGI,IMP	Homo_sapiens(9606)	Process
GO:0090263	involved_in positive regulation of canonical Wnt signaling pathway	1	IBA	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1902004	involved_in positive regulation of amyloid-beta formation	1	IEA	Homo_sapiens(9606)	Process
GO:1905426	involved_in positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation	1	NAS	Homo_sapiens(9606)	Process
GO:1990090	involved_in cellular response to nerve growth factor stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:1990904	part_of ribonucleoprotein complex	1	IEA	Homo_sapiens(9606)	Component
GO:2000052	involved_in positive regulation of non-canonical Wnt signaling pathway	1	IC	Homo_sapiens(9606)	Process