Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000213024 Gene ID 23636 Accession 8066
Symbol NUP62 Alias p62;IBSN;SNDI Full Name nucleoporin 62
Status Confidence Length 22940 bases Strand Minus strand
Position 19 : 49906825 - 49929764 RNA binding domain N.A.
Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
NUP62-201 ENST00000352066 3361 522aa ENSP00000305503
NUP62-202 ENST00000422090 3479 522aa ENSP00000407331
NUP62-223 ENST00000700473 3203 522aa ENSP00000515006
NUP62-221 ENST00000600935 3487 522aa ENSP00000468839
NUP62-224 ENST00000700474 3067 522aa ENSP00000515007
NUP62-209 ENST00000596437 3522 522aa ENSP00000468842
NUP62-210 ENST00000597029 2573 522aa ENSP00000473192
NUP62-225 ENST00000700475 2500 522aa ENSP00000515008
NUP62-213 ENST00000598301 3032 522aa ENSP00000515009
NUP62-217 ENST00000599788 2624 522aa ENSP00000468884
NUP62-219 ENST00000600583 2775 522aa ENSP00000515011
NUP62-226 ENST00000700476 2746 522aa ENSP00000515010
NUP62-227 ENST00000700477 2558 522aa ENSP00000515012
NUP62-215 ENST00000599560 2713 522aa ENSP00000515013
NUP62-228 ENST00000700478 2353 522aa ENSP00000515014
NUP62-211 ENST00000597723 1824 446aa ENSP00000469283
NUP62-208 ENST00000596217 3590 522aa ENSP00000471191
NUP62-206 ENST00000595463 563 No protein -
NUP62-203 ENST00000593652 905 137aa ENSP00000472918
NUP62-207 ENST00000595761 533 134aa ENSP00000468930
NUP62-216 ENST00000599567 579 100aa ENSP00000472081
NUP62-220 ENST00000600645 567 99aa ENSP00000470624
NUP62-204 ENST00000594673 564 36aa ENSP00000470157
NUP62-222 ENST00000601665 531 No protein -
NUP62-205 ENST00000595373 601 No protein -
NUP62-214 ENST00000599186 466 No protein -
NUP62-212 ENST00000597814 510 No protein -
NUP62-218 ENST00000599830 588 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
30568Monocytes3.8580000E-005-
53216Dehydroepiandrosterone5.4070000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000922located_in spindle pole1IDAHomo_sapiens(9606)Component
GO:0003682enables chromatin binding1NASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005543enables phospholipid binding1IBAHomo_sapiens(9606)Function
GO:0005635located_in nuclear envelope2IDA,TASHomo_sapiens(9606)Component
GO:0005643part_of nuclear pore2IDA,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,NASHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0006405involved_in RNA export from nucleus1IBAHomo_sapiens(9606)Process
GO:0006606involved_in protein import into nucleus1IBAHomo_sapiens(9606)Process
GO:0006913involved_in nucleocytoplasmic transport1NASHomo_sapiens(9606)Process
GO:0007080involved_in mitotic metaphase plate congression1IMPHomo_sapiens(9606)Process
GO:0007098involved_in centrosome cycle1IMPHomo_sapiens(9606)Process
GO:0007100involved_in mitotic centrosome separation1IMPHomo_sapiens(9606)Process
GO:0007166involved_in cell surface receptor signaling pathway2IDA,NASHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IDAHomo_sapiens(9606)Process
GO:0009966involved_in regulation of signal transduction1NASHomo_sapiens(9606)Process
GO:0017056enables structural constituent of nuclear pore1IBAHomo_sapiens(9606)Function
GO:0030159enables signaling receptor complex adaptor activity1IDAHomo_sapiens(9606)Function
GO:0030544enables Hsp70 protein binding1IEAHomo_sapiens(9606)Function
GO:0031965located_in nuclear membrane1IDAHomo_sapiens(9606)Component
GO:0042059involved_in negative regulation of epidermal growth factor receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0042169enables SH2 domain binding1IDAHomo_sapiens(9606)Function
GO:0043066involved_in negative regulation of apoptotic process1IDAHomo_sapiens(9606)Process
GO:0043069involved_in negative regulation of programmed cell death1IDAHomo_sapiens(9606)Process
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0043130enables ubiquitin binding1IDAHomo_sapiens(9606)Function
GO:0043407involved_in negative regulation of MAP kinase activity1IEAHomo_sapiens(9606)Process
GO:0044613part_of nuclear pore central transport channel1IBAHomo_sapiens(9606)Component
GO:0045742involved_in positive regulation of epidermal growth factor receptor signaling pathway1NASHomo_sapiens(9606)Process
GO:0045840involved_in positive regulation of mitotic nuclear division1IMPHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0046578involved_in regulation of Ras protein signal transduction1NASHomo_sapiens(9606)Process
GO:0046580involved_in negative regulation of Ras protein signal transduction1IEAHomo_sapiens(9606)Process
GO:0046601involved_in positive regulation of centriole replication1IMPHomo_sapiens(9606)Process
GO:0051028involved_in mRNA transport1IEAHomo_sapiens(9606)Process
GO:0051425enables PTB domain binding1IEAHomo_sapiens(9606)Function
GO:0051879enables Hsp90 protein binding1IEAHomo_sapiens(9606)Function
GO:0060236involved_in regulation of mitotic spindle organization1IMPHomo_sapiens(9606)Process
GO:0072686located_in mitotic spindle1IDAHomo_sapiens(9606)Component
GO:0090398involved_in cellular senescence1IEAHomo_sapiens(9606)Process
GO:0090543located_in Flemming body1IDAHomo_sapiens(9606)Component
GO:0098534involved_in centriole assembly1IMPHomo_sapiens(9606)Process
GO:1903438involved_in positive regulation of mitotic cytokinetic process1IMPHomo_sapiens(9606)Process
GO:1904781involved_in positive regulation of protein localization to centrosome1IMPHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component

Expression