Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions E3 ligase
Localizations Nucleoli
BulkPerturb-seq

Description

Ensembl ID ENSG00000204713 Gene ID 5987 Accession 9975
Symbol TRIM27 Alias RFP;RNF76 Full Name tripartite motif containing 27
Status Confidence Length 20987 bases Strand Minus strand
Position 6 : 28903002 - 28923988 RNA binding domain SPRY
Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000400058 SPRY PF00622 4.9e-21 1
ENSP00000366404 SPRY PF00622 1.8e-20 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34646390 A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection. Yiliang Wang 2021-01-01 Theranostics

Transcripts

Name Transcript ID bp Protein Translation ID
TRIM27-203 ENST00000414543 1813 248aa ENSP00000400058
TRIM27-205 ENST00000481474 7006 No protein -
TRIM27-201 ENST00000377194 2686 358aa ENSP00000366399
TRIM27-202 ENST00000377199 2963 513aa ENSP00000366404
TRIM27-204 ENST00000467742 541 No protein -
TRIM27-207 ENST00000498117 728 No protein -
TRIM27-206 ENST00000496091 687 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
51229Child Development Disorders, Pervasive1.1636700E-005-
67708Aggression2E-626087016

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II2IBA,IDAHomo_sapiens(9606)Process
GO:0001650located_in fibrillar center1IDAHomo_sapiens(9606)Component
GO:0002820involved_in negative regulation of adaptive immune response1IMPHomo_sapiens(9606)Process
GO:0003676enables nucleic acid binding1TASHomo_sapiens(9606)Function
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IC,IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IEAHomo_sapiens(9606)Component
GO:0005768located_in endosome1IDAHomo_sapiens(9606)Component
GO:0005769located_in early endosome1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006469involved_in negative regulation of protein kinase activity1IDAHomo_sapiens(9606)Process
GO:0007283involved_in spermatogenesis1TASHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0010507involved_in negative regulation of autophagy1IDAHomo_sapiens(9606)Process
GO:0016605located_in PML body1IEAHomo_sapiens(9606)Component
GO:0016925involved_in protein sumoylation1TASHomo_sapiens(9606)Process
GO:0019789enables SUMO transferase activity1EXPHomo_sapiens(9606)Function
GO:0031965located_in nuclear membrane1IDAHomo_sapiens(9606)Component
GO:0032480involved_in negative regulation of type I interferon production1IDAHomo_sapiens(9606)Process
GO:0032703involved_in negative regulation of interleukin-2 production1IMPHomo_sapiens(9606)Process
GO:0032720involved_in negative regulation of tumor necrosis factor production1IMPHomo_sapiens(9606)Process
GO:0032729involved_in positive regulation of type II interferon production1IMPHomo_sapiens(9606)Process
GO:0032897involved_in negative regulation of viral transcription2IBA,IDAHomo_sapiens(9606)Process
GO:0034314involved_in Arp2/3 complex-mediated actin nucleation1IDAHomo_sapiens(9606)Process
GO:0042147involved_in retrograde transport, endosome to Golgi1IDAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0044790involved_in suppression of viral release by host1IEAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response2IBA,IDAHomo_sapiens(9606)Process
GO:0045814acts_upstream_of_or_within negative regulation of gene expression, epigenetic1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1TASHomo_sapiens(9606)Function
GO:0051091involved_in positive regulation of DNA-binding transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0051127involved_in positive regulation of actin nucleation1IEAHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity3EXP,IBA,IDAHomo_sapiens(9606)Function
GO:0070534involved_in protein K63-linked ubiquitination2IBA,IMPHomo_sapiens(9606)Process
GO:0090281involved_in negative regulation of calcium ion import1IMPHomo_sapiens(9606)Process

Expression