Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Nucleoli
BulkPerturb-seq

Description

Ensembl ID ENSG00000198830 Gene ID 3151 Accession 4986
Symbol HMGN2 Alias HMG17 Full Name high mobility group nucleosomal binding domain 2
Status Confidence Length 4203 bases Strand Plus strand
Position 1 : 26472440 - 26476642 RNA binding domain N.A.
Summary The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
HMGN2-201 ENST00000361427 1940 90aa ENSP00000355228
HMGN2-207 ENST00000468388 320 No protein -
HMGN2-208 ENST00000479815 1030 No protein -
HMGN2-202 ENST00000460563 1045 No protein -
HMGN2-204 ENST00000464888 565 No protein -
HMGN2-203 ENST00000463817 853 No protein -
HMGN2-206 ENST00000467700 932 No protein -
HMGN2-205 ENST00000466194 952 No protein -
HMGN2-209 ENST00000493418 1496 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
43034Platelet Function Tests1.3666700E-005-
45187Platelet Function Tests1.8267700E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000785part_of chromatin1IEAHomo_sapiens(9606)Component
GO:0003682enables chromatin binding1IBAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1IDAHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0006325involved_in chromatin organization1IBAHomo_sapiens(9606)Process
GO:0031492enables nucleosomal DNA binding1IEAHomo_sapiens(9606)Function
GO:0031640involved_in killing of cells of another organism1IMPHomo_sapiens(9606)Process
GO:0061844involved_in antimicrobial humoral immune response mediated by antimicrobial peptide1IMPHomo_sapiens(9606)Process

Expression