Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000198721 Gene ID 10455 Accession 14601
Symbol ECI2 Alias DRS1;PECI;ACBD2;DRS-1;HCA88;dJ1013A10.3 Full Name enoyl-CoA delta isomerase 2
Status Confidence Length 19905 bases Strand Minus strand
Position 6 : 4115693 - 4135597 RNA binding domain N.A.
Summary This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
3040Glucose2.60158030620857E-2117903298
3487Cholesterol, HDL2.09529231629996E-617903299
3738Cholesterol, LDL2.07180106373531E-1017903299
4805Cholesterol, HDL2.00437953698962E-1017903299
5061Cholesterol, HDL1.40534911219302E-2417903299
5076Cholesterol, HDL2.2475757265793E-2417903299
9499Echocardiography8.61330295636456E-617903301
15199Heart Failure4.1043610E-004-
19690Blood Pressure9.221e-005-
22006Personality8.843e-005-
25475Coronary Artery Disease8.6050000E-005-
34156Leukoaraiosis1.8270801E-005-
34157Leukoaraiosis1.9236836E-005-
34227Asthma2.0022740E-005-
34466Platelet Function Tests3.7239400E-005-
35636Platelet Function Tests1.0155400E-005-
35729Platelet Function Tests1.9280600E-005-
35756Platelet Function Tests1.8589100E-005-
40723Platelet Function Tests3.6838400E-005-
47124Platelet Function Tests4.0907000E-005-
53738Transforming Growth Factor beta6.6280000E-005-
53739Transforming Growth Factor beta5.8630000E-005-
70333Neuroticism2E-627089181
91351Birth Weight1E-623251661

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000062enables fatty-acyl-CoA binding1IEAHomo_sapiens(9606)Function
GO:0004165enables delta(3)-delta(2)-enoyl-CoA isomerase activity1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005739is_active_in mitochondrion2IBA,IDAHomo_sapiens(9606)Component
GO:0005777is_active_in peroxisome2IBA,IDAHomo_sapiens(9606)Component
GO:0005782located_in peroxisomal matrix1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006635involved_in fatty acid beta-oxidation2IEA,ISSHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component

Expression