RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000197746	Gene ID	5660	Accession	9498
Symbol	PSAP	Alias	GLBA;SAP1;SAP2;PSAPD;PARK24	Full Name	prosaposin
Status	Confidence	Length	34954 bases	Strand	Minus strand
Position	10 : 71816298 - 71851251	RNA binding domain	N.A.
Summary	This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PSAP-201	ENST00000394936	2748	524aa	ENSP00000378394
PSAP-203	ENST00000495196	344	No protein	-
PSAP-202	ENST00000493143	576	No protein	-
PSAP-204	ENST00000633965	500	167aa	ENSP00000488331

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
84828	Asthma	8E-8	23829686

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002020	enables protease binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005543	enables phospholipid binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	2	HDA,TAS	Homo_sapiens(9606)	Component
GO:0005615	located_in extracellular space	3	HDA,IDA,ISS	Homo_sapiens(9606)	Component
GO:0005764	is_active_in lysosome	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005765	located_in lysosomal membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0005770	located_in late endosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006665	involved_in sphingolipid metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0007041	involved_in lysosomal transport	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	1	IBA	Homo_sapiens(9606)	Process
GO:0008047	enables enzyme activator activity	1	TAS	Homo_sapiens(9606)	Function
GO:0010506	involved_in regulation of autophagy	1	TAS	Homo_sapiens(9606)	Process
GO:0019216	involved_in regulation of lipid metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0035577	located_in azurophil granule membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0042803	enables protein homodimerization activity	1	IDA	Homo_sapiens(9606)	Function
GO:0043202	located_in lysosomal lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0060736	involved_in prostate gland growth	1	IBA	Homo_sapiens(9606)	Process
GO:0060742	involved_in epithelial cell differentiation involved in prostate gland development	1	IBA	Homo_sapiens(9606)	Process
GO:0062023	located_in collagen-containing extracellular matrix	1	HDA	Homo_sapiens(9606)	Component
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0097110	enables scaffold protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:1903771	involved_in positive regulation of beta-galactosidase activity	1	IDA	Homo_sapiens(9606)	Process
GO:1905572	involved_in ganglioside GM1 transport to membrane	1	IDA	Homo_sapiens(9606)	Process
GO:1905573	enables ganglioside GM1 binding	1	IDA	Homo_sapiens(9606)	Function
GO:1905574	enables ganglioside GM2 binding	1	IDA	Homo_sapiens(9606)	Function
GO:1905575	enables ganglioside GM3 binding	1	IDA	Homo_sapiens(9606)	Function
GO:1905576	enables ganglioside GT1b binding	1	IDA	Homo_sapiens(9606)	Function
GO:1905577	enables ganglioside GP1c binding	1	IDA	Homo_sapiens(9606)	Function