RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000197417	Gene ID	23729	Accession	1492
Symbol	SHPK	Alias	SHK;CARKL	Full Name	sedoheptulokinase
Status	Confidence	Length	28011 bases	Strand	Minus strand
Position	17 : 3608240 - 3636250	RNA binding domain	N.A.
Summary	The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
SHPK-201	ENST00000225519	3788	478aa	ENSP00000225519

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	ISS	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	2	IBA,TAS	Homo_sapiens(9606)	Component
GO:0005975	involved_in carbohydrate metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0006071	involved_in glycerol metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0006098	involved_in pentose-phosphate shunt	1	TAS	Homo_sapiens(9606)	Process
GO:0009052	involved_in pentose-phosphate shunt, non-oxidative branch	1	ISS	Homo_sapiens(9606)	Process
GO:0016310	involved_in phosphorylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0035963	involved_in cellular response to interleukin-13	1	ISS	Homo_sapiens(9606)	Process
GO:0043030	involved_in regulation of macrophage activation	1	ISS	Homo_sapiens(9606)	Process
GO:0050277	enables sedoheptulokinase activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0050727	involved_in regulation of inflammatory response	1	ISS	Homo_sapiens(9606)	Process
GO:0071222	involved_in cellular response to lipopolysaccharide	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0071353	involved_in cellular response to interleukin-4	1	ISS	Homo_sapiens(9606)	Process