Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000197299 Gene ID 641 Accession 1058
Symbol BLM Alias BS;RECQ2;RECQL2;RECQL3;MGRISCE1 Full Name BLM RecQ like helicase
Status Confidence Length 98821 bases Strand Plus strand
Position 15 : 90717346 - 90816166 RNA binding domain BDHCT , DEAD , HRDC
Summary The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junction, and is involved in several pathways contributing to the maintenance of genome stability. Identification of pathogenic Bloom variants is required for heterozygote testing in at-risk families. [provided by RefSeq, May 2020]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000506682 DEAD PF00270 5.9e-19 1
ENSP00000506682 HRDC PF00570 2.2e-11 2
ENSP00000506682 BDHCT PF08072 3.1e-21 3
ENSP00000497646 DEAD PF00270 6e-19 1
ENSP00000497646 HRDC PF00570 2.2e-11 2
ENSP00000497646 BDHCT PF08072 3.1e-21 3
ENSP00000347232 DEAD PF00270 6e-19 1
ENSP00000347232 HRDC PF00570 2.3e-11 2
ENSP00000347232 BDHCT PF08072 3.3e-21 3
ENSP00000506117 DEAD PF00270 6e-19 1
ENSP00000506117 HRDC PF00570 2.3e-11 2
ENSP00000506117 BDHCT PF08072 3.3e-21 3
ENSP00000454158 DEAD PF00270 6.4e-19 1
ENSP00000454158 BDHCT PF08072 2.8e-21 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37503837 BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures. M Yehuda Danino 2023-07-28 Nucleic acids research
36884289 The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges. N Ledoux 2023-05-01 Molecular biology of the cell
36569948 The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance. Sara Ovejero 2022-01-01 Frontiers in immunology
35440629 A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation. S Cohen 2022-04-19 Nature communications
36484368 N6‑methyladenosine‑induced long non‑coding RNA PVT1 regulates the miR‑27b‑3p/BLM axis to promote prostate cancer progression. Bin Chen 2023-01-01 International journal of oncology
25245947 RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. B Jagat Budhathoki 2014-10-01 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
BLM-201 ENST00000355112 5240 1417aa ENSP00000347232
BLM-213 ENST00000681142 4270 1372aa ENSP00000506682
BLM-211 ENST00000648453 4522 1386aa ENSP00000497646
BLM-208 ENST00000560509 3966 1286aa ENSP00000454158
BLM-206 ENST00000559724 4510 413aa ENSP00000453359
BLM-212 ENST00000680772 5033 1417aa ENSP00000506117
BLM-204 ENST00000559282 866 No protein -
BLM-202 ENST00000558599 577 No protein -
BLM-205 ENST00000559426 533 No protein -
BLM-207 ENST00000560136 2023 No protein -
BLM-209 ENST00000560559 2967 No protein -
BLM-203 ENST00000558825 1683 No protein -
BLM-210 ENST00000560821 1024 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
54710Erythropoietin2.8840000E-005-
56102alpha-Tocopherol5.4590000E-005-
73192delta-5 fatty acid desaturase8E-626584805
86998Rest9E-627126917
87738delta-5 fatty acid desaturase4E-626584805
92471Asthma1E-625918132
92472Toluene 2,4-Diisocyanate1E-625918132

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000197299homo_sapiensENSP0000041673954.237335.4391homo_sapiensENSP0000034723224.841216.2315
ENSG00000197299homo_sapiensENSP0000048231330.215216.9702homo_sapiensENSP0000034723225.758614.4672
ENSG00000197299homo_sapiensENSP0000029813932.332418.6453homo_sapiensENSP0000034723232.674718.8426
ENSG00000197299homo_sapiensENSP0000031763636.730623.5116homo_sapiensENSP0000034723225.688116.4432

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000197299homo_sapiensENSP0000034723297.388896.4008nomascus_leucogenysENSNLEP0000001473898.641997.6412
ENSG00000197299homo_sapiensENSP0000034723299.435498.7297pan_paniscusENSPPAP0000001815999.435498.7297
ENSG00000197299homo_sapiensENSP0000034723298.800397.6006pongo_abeliiENSPPYP0000000769498.800397.6006
ENSG00000197299homo_sapiensENSP0000034723299.153198.518pan_troglodytesENSPTRP0000001275499.153198.518
ENSG00000197299homo_sapiensENSP0000034723299.364998.518gorilla_gorillaENSGGOP0000000754899.505398.6572
ENSG00000197299homo_sapiensENSP0000034723271.418560.5505ornithorhynchus_anatinusENSOANP0000003562672.234161.242
ENSG00000197299homo_sapiensENSP0000034723277.275965.7728sarcophilus_harrisiiENSSHAP0000000922775.778564.4983
ENSG00000197299homo_sapiensENSP0000034723272.194861.5385notamacropus_eugeniiENSMEUP0000000663374.508463.5106
ENSG00000197299homo_sapiensENSP0000034723274.100268.1722choloepus_hoffmanniENSCHOP0000000554875.867169.7977
ENSG00000197299homo_sapiensENSP0000034723287.367781.6514dasypus_novemcinctusENSDNOP0000000787987.367781.6514
ENSG00000197299homo_sapiensENSP0000034723280.733973.2533erinaceus_europaeusENSEEUP0000000129782.718775.0542
ENSG00000197299homo_sapiensENSP0000034723261.538555.3282echinops_telfairiENSETEP0000001217061.27955.0949
ENSG00000197299homo_sapiensENSP0000034723295.906892.9428callithrix_jacchusENSCJAP0000004636996.042493.0742
ENSG00000197299homo_sapiensENSP0000034723297.459495.9774cercocebus_atysENSCATP0000003551197.528396.0452
ENSG00000197299homo_sapiensENSP0000034723297.671195.9774macaca_fascicularisENSMFAP0000002259397.740196.0452
ENSG00000197299homo_sapiensENSP0000034723297.741796.1186macaca_mulattaENSMMUP0000002565197.810796.1864
ENSG00000197299homo_sapiensENSP0000034723292.801790.5434macaca_nemestrinaENSMNEP0000001415795.636493.3091
ENSG00000197299homo_sapiensENSP0000034723297.671196.1186papio_anubisENSPANP0000001447397.740196.1864
ENSG00000197299homo_sapiensENSP0000034723295.130693.5074mandrillus_leucophaeusENSMLEP0000001752596.839195.1868
ENSG00000197299homo_sapiensENSP0000034723289.978884.3331tursiops_truncatusENSTTRP0000001553090.489784.8119
ENSG00000197299homo_sapiensENSP0000034723287.861782.0748vulpes_vulpesENSVVUP0000000852487.676181.9014
ENSG00000197299homo_sapiensENSP0000034723285.462276.6408mus_spretusMGP_SPRETEiJ_P008374385.522676.6949
ENSG00000197299homo_sapiensENSP0000034723289.62684.0508equus_asinusENSEASP0000500963287.525882.0813
ENSG00000197299homo_sapiensENSP0000034723288.426381.7925capra_hircusENSCHIP0000000655287.683781.1057
ENSG00000197299homo_sapiensENSP0000034723287.791181.1574panthera_leoENSPLOP0000002533977.507871.6511
ENSG00000197299homo_sapiensENSP0000034723288.426382.0042ailuropoda_melanoleucaENSAMEP0000001462188.053481.6585
ENSG00000197299homo_sapiensENSP0000034723289.13282.6394bos_indicus_hybridENSBIXP0000501467888.321781.8881
ENSG00000197299homo_sapiensENSP0000034723284.756575.4411oryctolagus_cuniculusENSOCUP0000001201084.936375.6011
ENSG00000197299homo_sapiensENSP0000034723290.472885.18equus_caballusENSECAP0000006887388.29283.1267
ENSG00000197299homo_sapiensENSP0000034723288.073482.2865canis_lupus_familiarisENSCAFP0084500342987.887382.1127
ENSG00000197299homo_sapiensENSP0000034723288.002881.2279panthera_pardusENSPPRP0000000722088.127281.3428
ENSG00000197299homo_sapiensENSP0000034723289.484882.7805marmota_marmota_marmotaENSMMMP0000002188590.056883.3097
ENSG00000197299homo_sapiensENSP0000034723290.825785.5328balaenoptera_musculusENSBMSP0001000312690.825785.5328
ENSG00000197299homo_sapiensENSP0000034723286.450278.1228cavia_porcellusENSCPOP0000000159287.188678.79
ENSG00000197299homo_sapiensENSP0000034723288.14481.2279felis_catusENSFCAP0000000565987.46580.6022
ENSG00000197299homo_sapiensENSP0000034723277.487666.7608monodelphis_domesticaENSMODP0000002426275.67265.1964
ENSG00000197299homo_sapiensENSP0000034723289.343782.9922bison_bison_bisonENSBBBP0000001586489.343782.9922
ENSG00000197299homo_sapiensENSP0000034723290.896385.3917monodon_monocerosENSMMNP0001500977889.693684.2618
ENSG00000197299homo_sapiensENSP0000034723290.190583.5568sus_scrofaENSSSCP0000000198689.245882.6816
ENSG00000197299homo_sapiensENSP0000034723291.743186.3091microcebus_murinusENSMICP0000004055291.678486.2482
ENSG00000197299homo_sapiensENSP0000034723264.008557.9393octodon_degusENSODEP0000002085089.89181.3677
ENSG00000197299homo_sapiensENSP0000034723261.679657.8687jaculus_jaculusENSJJAP0000001364188.461582.9959
ENSG00000197299homo_sapiensENSP0000034723288.14481.7219ovis_aries_rambouilletENSOARP0002002229487.403881.0357
ENSG00000197299homo_sapiensENSP0000034723288.285182.0748ursus_maritimusENSUMAP0000001237787.666481.4996
ENSG00000197299homo_sapiensENSP0000034723274.382565.561ochotona_princepsENSOPRP0000001066675.772866.7865
ENSG00000197299homo_sapiensENSP0000034723290.825785.1094delphinapterus_leucasENSDLEP0000001058690.06384.3947
ENSG00000197299homo_sapiensENSP0000034723290.755185.3917physeter_catodonENSPCTP0000503145089.867284.5563
ENSG00000197299homo_sapiensENSP0000034723284.68675.7939mus_caroliMGP_CAROLIEiJ_P008039484.985876.0623
ENSG00000197299homo_sapiensENSP0000034723285.1876.5702mus_musculusENSMUSP0000012799585.059976.4623
ENSG00000197299homo_sapiensENSP0000034723264.220259.4213dipodomys_ordiiENSDORP0000001036988.007781.4313
ENSG00000197299homo_sapiensENSP0000034723273.817969.1602mustela_putorius_furoENSMPUP0000001554785.667580.2621
ENSG00000197299homo_sapiensENSP0000034723296.04893.1545aotus_nancymaaeENSANAP0000004225196.183793.2862
ENSG00000197299homo_sapiensENSP0000034723286.66283.3451saimiri_boliviensis_boliviensisENSSBOP0000002925595.638691.9782
ENSG00000197299homo_sapiensENSP0000034723287.014880.8045vicugna_pacosENSVPAP0000000007887.199480.976
ENSG00000197299homo_sapiensENSP0000034723297.388895.6951chlorocebus_sabaeusENSCSAP0000001308296.978295.2916
ENSG00000197299homo_sapiensENSP0000034723265.06759.9153tupaia_belangeriENSTBEP0000000579966.811661.5217
ENSG00000197299homo_sapiensENSP0000034723285.956278.5462mesocricetus_auratusENSMAUP0000000727186.077778.6572
ENSG00000197299homo_sapiensENSP0000034723290.61484.8977phocoena_sinusENSPSNP0000000152289.790284.1259
ENSG00000197299homo_sapiensENSP0000034723290.261184.0508camelus_dromedariusENSCDRP0000501775489.503283.345
ENSG00000197299homo_sapiensENSP0000034723292.307787.0148carlito_syrichtaENSTSYP0000001135092.56987.2611
ENSG00000197299homo_sapiensENSP0000034723287.720581.0162panthera_tigris_altaicaENSPTIP0000001790187.720581.0162
ENSG00000197299homo_sapiensENSP0000034723284.262575.1588rattus_norvegicusENSRNOP0000001506585.164175.9629
ENSG00000197299homo_sapiensENSP0000034723292.166586.7325prolemur_simusENSPSMP0000001710392.231686.7938
ENSG00000197299homo_sapiensENSP0000034723285.038876.9231microtus_ochrogasterENSMOCP0000001793586.132977.9128
ENSG00000197299homo_sapiensENSP0000034723273.112266.2668sorex_araneusENSSARP0000000583478.366171.0287
ENSG00000197299homo_sapiensENSP0000034723286.097478.2639peromyscus_maniculatus_bairdiiENSPEMP0000001893086.341178.4855
ENSG00000197299homo_sapiensENSP0000034723289.343782.9217bos_mutusENSBMUP0000000953688.531582.1678
ENSG00000197299homo_sapiensENSP0000034723284.968276.2174mus_spicilegusENSMSIP0000000347285.088376.3251
ENSG00000197299homo_sapiensENSP0000034723286.026878.8285cricetulus_griseus_chok1gshdENSCGRP0000102807286.453979.2199
ENSG00000197299homo_sapiensENSP0000034723273.465167.3959pteropus_vampyrusENSPVAP0000001097573.67367.5867
ENSG00000197299homo_sapiensENSP0000034723287.438280.6634myotis_lucifugusENSMLUP0000001338187.872381.0638
ENSG00000197299homo_sapiensENSP0000034723277.417166.4079vombatus_ursinusENSVURP0001000841475.707464.9413
ENSG00000197299homo_sapiensENSP0000034723287.15679.5342rhinolophus_ferrumequinumENSRFEP0001003110787.15679.5342
ENSG00000197299homo_sapiensENSP0000034723287.367781.7219neovison_visonENSNVIP0000002114487.491281.8375
ENSG00000197299homo_sapiensENSP0000034723281.439775.3705bos_taurusENSBTAP0000002705787.623481.0934
ENSG00000197299homo_sapiensENSP0000034723263.373356.7396heterocephalus_glaber_femaleENSHGLP0000001847185.523876.5714
ENSG00000197299homo_sapiensENSP0000034723294.848392.8017rhinopithecus_bietiENSRBIP0000001157996.275194.1977
ENSG00000197299homo_sapiensENSP0000034723288.073482.4982canis_lupus_dingoENSCAFP0002002036987.887382.3239
ENSG00000197299homo_sapiensENSP0000034723291.10884.6154sciurus_vulgarisENSSVLP0000500948190.787684.3179
ENSG00000197299homo_sapiensENSP0000034723277.346565.9139phascolarctos_cinereusENSPCIP0000000791875.586264.4138
ENSG00000197299homo_sapiensENSP0000034723266.196261.115procavia_capensisENSPCAP0000000842066.477761.3749
ENSG00000197299homo_sapiensENSP0000034723288.14481.0868nannospalax_galiliENSNGAP0000000174988.518881.4316
ENSG00000197299homo_sapiensENSP0000034723289.343782.9217bos_grunniensENSBGRP0000001490088.531582.1678
ENSG00000197299homo_sapiensENSP0000034723287.226579.8165chinchilla_lanigeraENSCLAP0000001766288.034280.5556
ENSG00000197299homo_sapiensENSP0000034723289.202582.0748cervus_hanglu_yarkandensisENSCHYP0000002813288.391681.3287
ENSG00000197299homo_sapiensENSP0000034723288.355781.3691catagonus_wagneriENSCWAP0000001612288.231181.2544
ENSG00000197299homo_sapiensENSP0000034723289.978883.2039ictidomys_tridecemlineatusENSSTOP0000000449690.169783.3805
ENSG00000197299homo_sapiensENSP0000034723286.520879.1814otolemur_garnettiiENSOGAP0000000510487.508980.0857
ENSG00000197299homo_sapiensENSP0000034723294.707191.3903cebus_imitatorENSCCAP0000001063995.788792.434
ENSG00000197299homo_sapiensENSP0000034723290.190583.4862urocitellus_parryiiENSUPAP0001001896190.254283.5452
ENSG00000197299homo_sapiensENSP0000034723289.061481.7925moschus_moschiferusENSMMSP0000003150589.061481.7925
ENSG00000197299homo_sapiensENSP0000034723296.683194.9188rhinopithecus_roxellanaENSRROP0000002817796.751494.9859
ENSG00000197299homo_sapiensENSP0000034723285.1876.9231mus_pahariMGP_PahariEiJ_P001724385.724477.4148
ENSG00000197299homo_sapiensENSP0000034723288.002883.0628propithecus_coquereliENSPCOP0000000024192.233787.0562
ENSG00000197299homo_sapiensENSP0000034723233.098121.3832caenorhabditis_elegansT04A11.6.147.469630.668
ENSG00000197299homo_sapiensENSP0000034723243.542727.0289drosophila_melanogasterFBpp008191041.492925.7566
ENSG00000197299homo_sapiensENSP0000034723221.524314.9612ciona_intestinalisENSCINP0000003614055.555638.6157
ENSG00000197299homo_sapiensENSP0000034723239.449530.6281petromyzon_marinusENSPMAP0000000049575.134458.3333
ENSG00000197299homo_sapiensENSP0000034723230.134123.0064eptatretus_burgeriENSEBUP0000002557961.174846.7049
ENSG00000197299homo_sapiensENSP0000034723248.835639.8024callorhinchus_miliiENSCMIP0000004411371.193458.0247
ENSG00000197299homo_sapiensENSP0000034723264.925951.8701latimeria_chalumnaeENSLACP0000000731763.448350.6897
ENSG00000197299homo_sapiensENSP0000034723261.679646.6478lepisosteus_oculatusENSLOCP0000001760959.014244.632
ENSG00000197299homo_sapiensENSP0000034723210.3745.29287clupea_harengusENSCHAP0000001452945.370423.1481
ENSG00000197299homo_sapiensENSP0000034723261.256245.8716danio_rerioENSDARP0000015305160.319745.1703
ENSG00000197299homo_sapiensENSP0000034723261.185647.0007carassius_auratusENSCARP0000010760261.013446.8684
ENSG00000197299homo_sapiensENSP0000034723260.338746.2244astyanax_mexicanusENSAMXP0000001746760.296246.1918
ENSG00000197299homo_sapiensENSP0000034723253.422741.9195ictalurus_punctatusENSIPUP0000000072966.872852.4735
ENSG00000197299homo_sapiensENSP0000034723260.691646.4361esox_luciusENSELUP0000001979158.384344.6707
ENSG00000197299homo_sapiensENSP0000034723257.939346.0127electrophorus_electricusENSEEEP0000003503764.090650.8977
ENSG00000197299homo_sapiensENSP0000034723262.314847.2124oncorhynchus_kisutchENSOKIP0000501577360.06845.5102
ENSG00000197299homo_sapiensENSP0000034723261.891346.6478oncorhynchus_mykissENSOMYP0000006755261.029945.9986
ENSG00000197299homo_sapiensENSP0000034723262.808846.9301salmo_salarENSSSAP0000011048460.503145.2073
ENSG00000197299homo_sapiensENSP0000034723262.667646.789salmo_truttaENSSTUP0000008646260.121944.8883
ENSG00000197299homo_sapiensENSP0000034723214.961211.0092gadus_morhuaENSGMOP0000001151863.855446.988
ENSG00000197299homo_sapiensENSP0000034723221.524316.302gadus_morhuaENSGMOP0000001163464.48248.8372
ENSG00000197299homo_sapiensENSP0000034723259.280242.9781gadus_morhuaENSGMOP0000001788661.269144.4201
ENSG00000197299homo_sapiensENSP0000034723260.691645.5893fundulus_heteroclitusENSFHEP0000000180161.2145.9786
ENSG00000197299homo_sapiensENSP0000034723261.326745.4481poecilia_reticulataENSPREP0000001131162.115846.0329
ENSG00000197299homo_sapiensENSP0000034723260.409345.1658xiphophorus_maculatusENSXMAP0000002737261.230345.7797
ENSG00000197299homo_sapiensENSP0000034723260.832746.0127oryzias_latipesENSORLP0000002704861.880846.8055
ENSG00000197299homo_sapiensENSP0000034723259.068544.6718cyclopterus_lumpusENSCLMP0000501637161.725746.6814
ENSG00000197299homo_sapiensENSP0000034723261.467945.3776oreochromis_niloticusENSONIP0000001912461.904845.7001
ENSG00000197299homo_sapiensENSP0000034723261.185645.6598haplochromis_burtoniENSHBUP0000001412261.708246.0498
ENSG00000197299homo_sapiensENSP0000034723260.550545.0953astatotilapia_callipteraENSACLP0000003003161.637945.9052
ENSG00000197299homo_sapiensENSP0000034723259.350746.1538sparus_aurataENSSAUP0001005133558.688145.6385
ENSG00000197299homo_sapiensENSP0000034723260.973946.6478lates_calcariferENSLCAP0001001068361.146546.7799
ENSG00000197299homo_sapiensENSP0000034723262.879349.6119xenopus_tropicalisENSXETP0000001715465.131651.3889
ENSG00000197299homo_sapiensENSP0000034723261.60948.6239chrysemys_picta_belliiENSCPBP0000003611368.794354.2947
ENSG00000197299homo_sapiensENSP0000034723256.739644.813sphenodon_punctatusENSSPUP0000000008173.357757.938
ENSG00000197299homo_sapiensENSP0000034723267.254852.5759crocodylus_porosusENSCPRP0000500286465.006850.8186
ENSG00000197299homo_sapiensENSP0000034723262.314847.6358laticauda_laticaudataENSLLTP0000002237362.226947.5687
ENSG00000197299homo_sapiensENSP0000034723223.359219.9012notechis_scutatusENSNSUP0000002849481.930769.802
ENSG00000197299homo_sapiensENSP0000034723245.095338.391pseudonaja_textilisENSPTXP0000002238483.638771.2042
ENSG00000197299homo_sapiensENSP0000034723261.397348.765anas_platyrhynchos_platyrhynchosENSAPLP0000000651466.820353.0722
ENSG00000197299homo_sapiensENSP0000034723263.937951.0233gallus_gallusENSGALP0001002280765.652252.3913
ENSG00000197299homo_sapiensENSP0000034723259.13947.2124meleagris_gallopavoENSMGAP0000001088266.719753.2643
ENSG00000197299homo_sapiensENSP0000034723256.104445.1658serinus_canariaENSSCAP0000001798765.217452.5021
ENSG00000197299homo_sapiensENSP0000034723253.352243.1193parus_majorENSPMJP0000001534164.615452.2222
ENSG00000197299homo_sapiensENSP0000034723262.949949.753anolis_carolinensisENSACAP0000002502763.172849.9292
ENSG00000197299homo_sapiensENSP0000034723260.903345.6598neolamprologus_brichardiENSNBRP0000002579362.490946.8501
ENSG00000197299homo_sapiensENSP0000034723257.868744.6013naja_najaENSNNAP0000002209464.770949.921
ENSG00000197299homo_sapiensENSP0000034723252.928743.5427podarcis_muralisENSPMRP0000003301373.242260.2539
ENSG00000197299homo_sapiensENSP0000034723254.410744.5307geospiza_fortisENSGFOP0000001916471.322858.3719
ENSG00000197299homo_sapiensENSP0000034723258.221647.283taeniopygia_guttataENSTGUP0000001028663.461551.5385
ENSG00000197299homo_sapiensENSP0000034723262.879347.0713erpetoichthys_calabaricusENSECRP0000003097260.612245.3741
ENSG00000197299homo_sapiensENSP0000034723259.421344.813kryptolebias_marmoratusENSKMAP0000002238560.838245.8815
ENSG00000197299homo_sapiensENSP0000034723261.961947.3536salvator_merianaeENSSMRP0000002799463.623248.6232
ENSG00000197299homo_sapiensENSP0000034723260.973945.9421oryzias_javanicusENSOJAP0000003109061.846846.5999
ENSG00000197299homo_sapiensENSP0000034723260.62144.813amphilophus_citrinellusENSACIP0000003078562.291546.0479
ENSG00000197299homo_sapiensENSP0000034723260.550545.307dicentrarchus_labraxENSDLAP0000502917260.210545.0526
ENSG00000197299homo_sapiensENSP0000034723260.338745.2364amphiprion_perculaENSAPEP0000002545059.457644.5758
ENSG00000197299homo_sapiensENSP0000034723260.903346.0127oryzias_sinensisENSOSIP0000001575861.952646.8055
ENSG00000197299homo_sapiensENSP0000034723235.709230.7692pelodiscus_sinensisENSPSIP0000001082790.843878.2765
ENSG00000197299homo_sapiensENSP0000034723255.469344.8836gopherus_evgoodeiENSGEVP0000501516070.367156.9382
ENSG00000197299homo_sapiensENSP0000034723255.257644.813chelonoidis_abingdoniiENSCABP0000001008574.785160.6495
ENSG00000197299homo_sapiensENSP0000034723260.338745.5187seriola_dumeriliENSSDUP0000001499861.422446.3362
ENSG00000197299homo_sapiensENSP0000034723258.292243.5427cottoperca_gobioENSCGOP0000003257459.63944.5487
ENSG00000197299homo_sapiensENSP0000034723262.738249.259struthio_camelus_australisENSSCUP0000001773569.129154.2768
ENSG00000197299homo_sapiensENSP0000034723265.913952.1524anser_brachyrhynchusENSABRP0000000760565.087151.4983
ENSG00000197299homo_sapiensENSP0000034723259.068544.319gasterosteus_aculeatusENSGACP0000001438361.544146.1765
ENSG00000197299homo_sapiensENSP0000034723256.245643.1193cynoglossus_semilaevisENSCSEP0000002112861.307747
ENSG00000197299homo_sapiensENSP0000034723260.762245.4481poecilia_formosaENSPFOP0000000519963.030747.1449
ENSG00000197299homo_sapiensENSP0000034723260.409345.7304myripristis_murdjanENSMMDP0000500107860.580345.8599
ENSG00000197299homo_sapiensENSP0000034723259.421344.6718sander_luciopercaENSSLUP0000002009061.325646.1034
ENSG00000197299homo_sapiensENSP0000034723254.410744.813strigops_habroptilaENSSHBP0000500921272.530659.7366
ENSG00000197299homo_sapiensENSP0000034723260.268245.1658amphiprion_ocellarisENSAOCP0000001972862.06446.5116
ENSG00000197299homo_sapiensENSP0000034723258.221645.5893terrapene_carolina_triunguisENSTMTP0000001436768.351353.5211
ENSG00000197299homo_sapiensENSP0000034723261.961946.8596hucho_huchoENSHHUP0000004678060.260845.5731
ENSG00000197299homo_sapiensENSP0000034723260.832745.8716betta_splendensENSBSLP0000004918361.352346.2633
ENSG00000197299homo_sapiensENSP0000034723259.985946.8596pygocentrus_nattereriENSPNAP0000000550960.541347.2934
ENSG00000197299homo_sapiensENSP0000034723260.479945.4481anabas_testudineusENSATEP0000000912262.28246.8023
ENSG00000197299homo_sapiensENSP0000034723223.147515.5963ciona_savignyiENSCSAVP0000001280355.877337.6491
ENSG00000197299homo_sapiensENSP0000034723239.661322.3712saccharomyces_cerevisiaeYMR190C38.83921.9074
ENSG00000197299homo_sapiensENSP0000034723260.479945.7304seriola_lalandi_dorsalisENSSLDP0000000067961.610446.5852
ENSG00000197299homo_sapiensENSP0000034723245.095336.1327labrus_bergyltaENSLBEP0000002446175.531960.5201
ENSG00000197299homo_sapiensENSP0000034723255.539939.379pundamilia_nyerereiENSPNYP0000001448458.775241.6729
ENSG00000197299homo_sapiensENSP0000034723260.691646.5773mastacembelus_armatusENSMAMP0000001284861.604647.2779
ENSG00000197299homo_sapiensENSP0000034723260.691645.8716stegastes_partitusENSSPAP0000001858661.2146.2633
ENSG00000197299homo_sapiensENSP0000034723262.808847.2124oncorhynchus_tshawytschaENSOTSP0000504779260.46245.4484
ENSG00000197299homo_sapiensENSP0000034723259.703644.813acanthochromis_polyacanthusENSAPOP0000001504160.170745.1636
ENSG00000197299homo_sapiensENSP0000034723263.020550.1764aquila_chrysaetos_chrysaetosENSACCP0002000359966.691653.0993
ENSG00000197299homo_sapiensENSP0000034723257.727642.7664nothobranchius_furzeriENSNFUP0001501569650.030637.0642
ENSG00000197299homo_sapiensENSP0000034723242.060729.0755cyprinodon_variegatusENSCVAP0000001469454.628837.7635
ENSG00000197299homo_sapiensENSP0000034723259.985946.0833denticeps_clupeoidesENSDCDP0000001586259.77545.9212
ENSG00000197299homo_sapiensENSP0000034723259.915345.1658larimichthys_croceaENSLCRP0000505596060.513245.6165
ENSG00000197299homo_sapiensENSP0000034723257.65743.4721takifugu_rubripesENSTRUP0000007869558.608344.1894
ENSG00000197299homo_sapiensENSP0000034723254.128444.319ficedula_albicollisENSFALP0000001147770.045757.3516
ENSG00000197299homo_sapiensENSP0000034723249.75339.8024hippocampus_comesENSHCOP0000002314672.981458.3851
ENSG00000197299homo_sapiensENSP0000034723261.185646.3656cyprinus_carpio_carpioENSCCRP0000011709460.250245.6567
ENSG00000197299homo_sapiensENSP0000034723259.703645.307cyprinus_carpio_carpioENSCCRP0000015467058.506244.3983
ENSG00000197299homo_sapiensENSP0000034723262.59749.8236coturnix_japonicaENSCJPP0000502723164.603151.4202
ENSG00000197299homo_sapiensENSP0000034723260.762245.4481poecilia_latipinnaENSPLAP0000002818463.030747.1449
ENSG00000197299homo_sapiensENSP0000034723227.946421.5243sinocyclocheilus_grahamiENSSGRP0000006498766.331751.0888
ENSG00000197299homo_sapiensENSP0000034723256.17543.0487sinocyclocheilus_grahamiENSSGRP0000008957861.136746.851
ENSG00000197299homo_sapiensENSP0000034723260.62145.307maylandia_zebraENSMZEP0000502994662.201346.4881
ENSG00000197299homo_sapiensENSP0000034723258.221643.825tetraodon_nigroviridisENSTNIP0000002244761.659246.4126
ENSG00000197299homo_sapiensENSP0000034723260.550546.8596paramormyrops_kingsleyaeENSPKIP0000002650159.500746.0472
ENSG00000197299homo_sapiensENSP0000034723261.891348.4121leptobrachium_leishanenseENSLLEP0000002483960.776247.5398
ENSG00000197299homo_sapiensENSP0000034723260.973945.801scophthalmus_maximusENSSMAP0000006400861.935546.5233
ENSG00000197299homo_sapiensENSP0000034723260.479945.1658oryzias_melastigmaENSOMEP0000003600362.646246.7836

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000079involved_in regulation of cyclin-dependent protein serine/threonine kinase activity1IMPHomo_sapiens(9606)Process
GO:0000228located_in nuclear chromosome1IDAHomo_sapiens(9606)Component
GO:0000400enables four-way junction DNA binding1IDAHomo_sapiens(9606)Function
GO:0000403enables Y-form DNA binding1IDAHomo_sapiens(9606)Function
GO:0000405enables bubble DNA binding1IDAHomo_sapiens(9606)Function
GO:0000723involved_in telomere maintenance1IBAHomo_sapiens(9606)Process
GO:0000724involved_in double-strand break repair via homologous recombination3IBA,IDA,NASHomo_sapiens(9606)Process
GO:0000729involved_in DNA double-strand break processing1IDAHomo_sapiens(9606)Process
GO:0000781colocalizes_with chromosome, telomeric region1IDAHomo_sapiens(9606)Component
GO:0000800located_in lateral element1IDAHomo_sapiens(9606)Component
GO:0002039enables p53 binding1IPIHomo_sapiens(9606)Function
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003678enables DNA helicase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0003697enables single-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:0004386enables helicase activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005657located_in replication fork1ISSHomo_sapiens(9606)Component
GO:0005694is_active_in chromosome1IBAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0006260involved_in DNA replication1ISSHomo_sapiens(9606)Process
GO:0006268involved_in DNA unwinding involved in DNA replication1IBAHomo_sapiens(9606)Process
GO:0006281involved_in DNA repair1NASHomo_sapiens(9606)Process
GO:0006310involved_in DNA recombination1NASHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response2IDA,IMPHomo_sapiens(9606)Process
GO:0007095involved_in mitotic G2 DNA damage checkpoint signaling1IDAHomo_sapiens(9606)Process
GO:0008094enables ATP-dependent activity, acting on DNA1IDAHomo_sapiens(9606)Function
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0009378enables four-way junction helicase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0010165involved_in response to X-ray1IDAHomo_sapiens(9606)Process
GO:0016363located_in nuclear matrix1IDAHomo_sapiens(9606)Component
GO:0016605colocalizes_with PML body2IDAHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity1IEAHomo_sapiens(9606)Function
GO:0031297involved_in replication fork processing1IDAHomo_sapiens(9606)Process
GO:0031422part_of RecQ family helicase-topoisomerase III complex1IPIHomo_sapiens(9606)Component
GO:0032201involved_in telomere maintenance via semi-conservative replication1TASHomo_sapiens(9606)Process
GO:0032508involved_in DNA duplex unwinding1IDAHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IDAHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IDAHomo_sapiens(9606)Function
GO:0043138enables 3-5 DNA helicase activity2IBA,TASHomo_sapiens(9606)Function
GO:0044806involved_in G-quadruplex DNA unwinding3IBA,IDA,ISSHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045910involved_in negative regulation of DNA recombination1IMPHomo_sapiens(9606)Process
GO:0051259involved_in protein complex oligomerization1IDAHomo_sapiens(9606)Process
GO:0051260involved_in protein homooligomerization1IDAHomo_sapiens(9606)Process
GO:0051782involved_in negative regulation of cell division1IMPHomo_sapiens(9606)Process
GO:0051880enables G-quadruplex DNA binding1IDAHomo_sapiens(9606)Function
GO:0061749enables forked DNA-dependent helicase activity1IDAHomo_sapiens(9606)Function
GO:0061820involved_in telomeric D-loop disassembly1IDAHomo_sapiens(9606)Process
GO:0061821enables telomeric D-loop binding1IDAHomo_sapiens(9606)Function
GO:0061849enables telomeric G-quadruplex DNA binding1IDAHomo_sapiens(9606)Function
GO:0071139involved_in resolution of recombination intermediates1IDAHomo_sapiens(9606)Process
GO:0071479involved_in cellular response to ionizing radiation1IDAHomo_sapiens(9606)Process
GO:0072711involved_in cellular response to hydroxyurea1IDAHomo_sapiens(9606)Process
GO:0072757involved_in cellular response to camptothecin1IDAHomo_sapiens(9606)Process
GO:0090329involved_in regulation of DNA-templated DNA replication1IMPHomo_sapiens(9606)Process
GO:0090656involved_in t-circle formation1TASHomo_sapiens(9606)Process
GO:0140677enables molecular function activator activity1IDAHomo_sapiens(9606)Function
GO:1905773enables 8-hydroxy-2-deoxyguanosine DNA binding1IDAHomo_sapiens(9606)Function
GO:1990814enables DNA/DNA annealing activity1IDAHomo_sapiens(9606)Function

Expression