RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000196498	Gene ID	9612	Accession	7673
Symbol	NCOR2	Alias	SMRT;TRAC;CTG26;SMRTE;TRAC1;N-CoR2;TNRC14;TRAC-1;SMAP270;SMRTE-tau	Full Name	nuclear receptor corepressor 2
Status	Confidence	Length	243198 bases	Strand	Minus strand
Position	12 : 124324415 - 124567612	RNA binding domain	N.A.
Summary	This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
34145290	The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis.	Liu Teng	2021-06-18	Nature communications
29789295	Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks.	Mark Grimes	2018-05-22	Science signaling

Name	Transcript ID	bp	Protein	Translation ID
NCOR2-201	ENST00000404621	8520	2458aa	ENSP00000384202
NCOR2-202	ENST00000405201	9001	2514aa	ENSP00000384018
NCOR2-206	ENST00000429285	8475	2504aa	ENSP00000400281
NCOR2-204	ENST00000418829	563	129aa	ENSP00000391389
NCOR2-209	ENST00000443451	951	No protein	-
NCOR2-203	ENST00000413172	532	132aa	ENSP00000407357
NCOR2-215	ENST00000464377	499	No protein	-
NCOR2-208	ENST00000440337	956	134aa	ENSP00000398963
NCOR2-214	ENST00000461081	2910	No protein	-
NCOR2-217	ENST00000474079	321	No protein	-
NCOR2-207	ENST00000440187	467	156aa	ENSP00000396044
NCOR2-212	ENST00000453428	674	225aa	ENSP00000400687
NCOR2-213	ENST00000458234	4675	1451aa	ENSP00000402808
NCOR2-216	ENST00000473999	1277	No protein	-
NCOR2-220	ENST00000536195	452	No protein	-
NCOR2-218	ENST00000493859	557	No protein	-
NCOR2-211	ENST00000448614	582	162aa	ENSP00000408247
NCOR2-205	ENST00000420698	1752	493aa	ENSP00000405367
NCOR2-219	ENST00000494460	339	No protein	-
NCOR2-222	ENST00000542927	828	275aa	ENSP00000443689
NCOR2-210	ENST00000448008	735	245aa	ENSP00000403034
NCOR2-221	ENST00000542565	746	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
8058	Neoplasms	3.80520147097714E-5	17903305
8068	Neoplasms	4.9494767905779E-5	17903305
14249	Iron	7.2780000E-004	19880490
23234	Body Height	1.0840000E-005	-
23532	Body Height	6.8760000E-005	-
23609	Body Height	2.4520000E-005	-
45155	Platelet Function Tests	3.8094700E-005	-
73065	Cocaine-Related Disorders	5E-7	23958962
88056	Neuropsychological Tests	7E-6	19734545
102843	Antimetabolites	9E-6	23648065
102844	Antineoplastic Agents	9E-6	23648065

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0000785	part_of chromatin	1	IDA	Homo_sapiens(9606)	Component
GO:0003677	enables DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003682	enables chromatin binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003714	enables transcription corepressor activity	3	IBA,IDA,IMP	Homo_sapiens(9606)	Function
GO:0005112	enables Notch binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	2	IC,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0007595	involved_in lactation	1	IEA	Homo_sapiens(9606)	Process
GO:0010243	involved_in response to organonitrogen compound	1	IEA	Homo_sapiens(9606)	Process
GO:0010565	involved_in regulation of cellular ketone metabolic process	1	IMP	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016363	located_in nuclear matrix	1	IDA	Homo_sapiens(9606)	Component
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component
GO:0017053	part_of transcription repressor complex	1	IDA	Homo_sapiens(9606)	Component
GO:0021549	involved_in cerebellum development	1	IEA	Homo_sapiens(9606)	Process
GO:0032355	involved_in response to estradiol	1	IEA	Homo_sapiens(9606)	Process
GO:0035259	enables nuclear glucocorticoid receptor binding	1	IEA	Homo_sapiens(9606)	Function
GO:0042826	enables histone deacetylase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0044849	involved_in estrous cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IMP	Homo_sapiens(9606)	Process
GO:0046965	enables nuclear retinoid X receptor binding	1	IEA	Homo_sapiens(9606)	Function
GO:0060766	involved_in negative regulation of androgen receptor signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:1902894	involved_in negative regulation of miRNA transcription	1	IMP	Homo_sapiens(9606)	Process