RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000196187	Gene ID	9725	Accession	29118
Symbol	TMEM63A	Alias	HLD19;KIAA0792	Full Name	transmembrane protein 63A
Status	Confidence	Length	36845 bases	Strand	Minus strand
Position	1 : 225845536 - 225882380	RNA binding domain	PHM7_cyt
Summary	Enables mechanosensitive ion channel activity. Predicted to be involved in cation transmembrane transport. Located in centriolar satellite and lysosomal membrane. Implicated in hypomyelinating leukodystrophy. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000355800	PHM7_cyt	PF14703	1.7e-43	1
ENSP00000445237	PHM7_cyt	PF14703	2.9e-15	1

Showing 1 to 2 of 2 entries

Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
TMEM63A-201	ENST00000366835	4109	807aa	ENSP00000355800
TMEM63A-202	ENST00000436966	454	118aa	ENSP00000409002
TMEM63A-203	ENST00000474478	5407	No protein	-
TMEM63A-204	ENST00000482753	405	No protein	-
TMEM63A-205	ENST00000483779	634	No protein	-
TMEM63A-206	ENST00000487817	660	No protein	-
TMEM63A-207	ENST00000487971	488	No protein	-
TMEM63A-208	ENST00000496025	789	No protein	-
TMEM63A-209	ENST00000537914	1018	82aa	ENSP00000445237

Showing 1 to 9 of 9 entries

Gene Model

Click here to download ENSG00000196187's gene model file

Protein-Protein Interaction (PPI)

Click here to download ENSG00000196187's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000196187	homo_sapiens	ENSP00000327154	70.0721	53.8462	homo_sapiens	ENSP00000355800	72.2429	55.5143
ENSG00000196187	homo_sapiens	ENSP00000298351	57.196	38.5856	homo_sapiens	ENSP00000355800	57.1252	38.5378

Showing 1 to 2 of 2 entries

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000196187	homo_sapiens	ENSP00000355800	87.3606	86.2454	nomascus_leucogenys	ENSNLEP00000016686	97.2414	96
ENSG00000196187	homo_sapiens	ENSP00000355800	100	99.8761	pan_paniscus	ENSPPAP00000023707	100	99.8761
ENSG00000196187	homo_sapiens	ENSP00000355800	99.5043	98.7608	pongo_abelii	ENSPPYP00000024509	99.5043	98.7608
ENSG00000196187	homo_sapiens	ENSP00000355800	99.8761	99.7522	pan_troglodytes	ENSPTRP00000003445	99.8761	99.7522
ENSG00000196187	homo_sapiens	ENSP00000355800	99.7522	99.5043	gorilla_gorilla	ENSGGOP00000000850	98.8943	98.6487
ENSG00000196187	homo_sapiens	ENSP00000355800	86.4932	76.3321	ornithorhynchus_anatinus	ENSOANP00000002346	63.4545	56
ENSG00000196187	homo_sapiens	ENSP00000355800	87.8563	79.9257	sarcophilus_harrisii	ENSSHAP00000032940	88.0745	80.1242
ENSG00000196187	homo_sapiens	ENSP00000355800	87.4845	79.1822	notamacropus_eugenii	ENSMEUP00000002951	90.2813	81.7136
ENSG00000196187	homo_sapiens	ENSP00000355800	40.3965	38.4139	choloepus_hoffmanni	ENSCHOP00000000972	51.5008	48.9731
ENSG00000196187	homo_sapiens	ENSP00000355800	86.3693	76.2082	dasypus_novemcinctus	ENSDNOP00000025728	87.4529	77.1644

Showing 1 to 10 of 198 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005886	is_active_in plasma membrane	3	IBA,ISS,TAS	Homo_sapiens(9606)	Component
GO:0005765	located_in lysosomal membrane	2	HDA,IDA	Homo_sapiens(9606)	Component
GO:0008381	enables mechanosensitive monoatomic ion channel activity	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0003676	enables nucleic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005227	enables calcium activated cation channel activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0034451	located_in centriolar satellite	1	IDA	Homo_sapiens(9606)	Component
GO:0035579	located_in specific granule membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component

Showing 1 to 10 of 13 entries

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Expression

Contents

Description
RBDs
Transcripts
Gene Model
PPI
Paralogs
Orthologs
Gene Ontology
Expression