RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000189057	Gene ID	374393	Accession	24200
Symbol	FAM111B	Alias	CANP;POIKTMP	Full Name	FAM111 trypsin like peptidase B
Status	Confidence	Length	20228 bases	Strand	Plus strand
Position	11 : 59107185 - 59127412	RNA binding domain	N.A.
Summary	This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
FAM111B-202	ENST00000411426	3344	704aa	ENSP00000393855
FAM111B-203	ENST00000528234	574	No protein	-
FAM111B-204	ENST00000529618	2364	704aa	ENSP00000432875
FAM111B-205	ENST00000534403	557	162aa	ENSP00000432143
FAM111B-201	ENST00000343597	3506	734aa	ENSP00000341565
FAM111B-206	ENST00000620384	3405	734aa	ENSP00000483456

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000785	part_of chromatin	1	IBA	Homo_sapiens(9606)	Component
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0006260	involved_in DNA replication	1	IBA	Homo_sapiens(9606)	Process
GO:0006508	involved_in proteolysis	1	IEA	Homo_sapiens(9606)	Process
GO:0008233	enables peptidase activity	1	IEA	Homo_sapiens(9606)	Function