RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	tRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000188917	Gene ID	79979	Accession	25748
Symbol	TRMT2B	Alias	CXorf34;dJ341D10.3	Full Name	tRNA methyltransferase 2 homolog B
Status	Confidence	Length	42771 bases	Strand	Minus strand
Position	X : 101009346 - 101052116	RNA binding domain	Methyltransf_31 , tRNA_U5-meth_tr
Summary	This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000362030	tRNA_U5-meth_tr	PF05958	5.9e-09	1
ENSP00000362030	Methyltransf_31	PF13847	2.3e-07	2
ENSP00000362026	tRNA_U5-meth_tr	PF05958	7.5e-09	1
ENSP00000362026	Methyltransf_31	PF13847	2e-07	2
ENSP00000362027	tRNA_U5-meth_tr	PF05958	7.5e-09	1
ENSP00000362027	Methyltransf_31	PF13847	2e-07	2
ENSP00000438134	tRNA_U5-meth_tr	PF05958	7.5e-09	1
ENSP00000438134	Methyltransf_31	PF13847	2e-07	2

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
TRMT2B-203	ENST00000372939	3078	459aa	ENSP00000362030
TRMT2B-201	ENST00000372935	2921	504aa	ENSP00000362026
TRMT2B-202	ENST00000372936	3547	504aa	ENSP00000362027
TRMT2B-204	ENST00000478422	771	No protein	-
TRMT2B-205	ENST00000488615	627	No protein	-
TRMT2B-206	ENST00000545398	3106	504aa	ENSP00000438134

Gene Model

Click here to download ENSG00000188917's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000188917's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005739	is_active_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	IDA	Homo_sapiens(9606)	Component
GO:0030488	involved_in tRNA methylation	1	IEA	Homo_sapiens(9606)	Process
GO:0030697	enables S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0031167	involved_in rRNA methylation	1	IEA	Homo_sapiens(9606)	Process
GO:0070041	enables rRNA (uridine-C5-)-methyltransferase activity	1	IDA	Homo_sapiens(9606)	Function

Expression