Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000188906 Gene ID 120892 Accession 18618
Symbol LRRK2 Alias PARK8;RIPK7;ROCO2;AURA17;DARDARIN Full Name leucine rich repeat kinase 2
Status Confidence Length 172542 bases Strand Plus strand
Position 12 : 40196744 - 40369285 RNA binding domain N.A.
Summary This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Aifu Lin 2016-02-01 Nature cell biology
37360399 Target 2035 - an update on private sector contributions. Suzanne Ackloo 2023-06-22 RSC medicinal chemistry
28860483 Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells. Kenneth Thirstrup 2017-08-31 Scientific reports

Transcripts

Name Transcript ID bp Protein Translation ID
LRRK2-203 ENST00000416796 1655 521aa ENSP00000398726
LRRK2-214 ENST00000680235 2344 No protein -
LRRK2-210 ENST00000679360 7718 403aa ENSP00000505368
LRRK2-201 ENST00000298910 9239 2527aa ENSP00000298910
LRRK2-202 ENST00000343742 4740 1271aa ENSP00000341930
LRRK2-218 ENST00000680790 8875 2442aa ENSP00000505335
LRRK2-209 ENST00000644108 1151 78aa ENSP00000493752
LRRK2-205 ENST00000474202 556 No protein -
LRRK2-204 ENST00000430804 6400 207aa ENSP00000410821
LRRK2-206 ENST00000479187 8306 No protein -
LRRK2-220 ENST00000681696 3828 1052aa ENSP00000505871
LRRK2-211 ENST00000679532 4852 171aa ENSP00000506435
LRRK2-213 ENST00000680018 4523 73aa ENSP00000505347
LRRK2-215 ENST00000680422 8598 843aa ENSP00000505304
LRRK2-217 ENST00000680453 4515 160aa ENSP00000505566
LRRK2-216 ENST00000680425 3968 43aa ENSP00000506459
LRRK2-219 ENST00000681136 4081 No protein -
LRRK2-207 ENST00000481256 561 No protein -
LRRK2-212 ENST00000679683 2855 59aa ENSP00000506105
LRRK2-208 ENST00000636518 2477 454aa ENSP00000490200
LRRK2-221 ENST00000681773 4718 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
31077Neutrophils9.8260000E-005-
37559Platelet Function Tests1.6259700E-005-
52511Child Development Disorders, Pervasive7.9000000E-005-
52512Child Development Disorders, Pervasive7.8000000E-005-
62964C-Peptide5E-623251661
66527Parkinson Disease6E-1421292315
67584Parkinson Disease6E-1522438815
69746Crohn Disease6E-2028067908
77638Parkinson Disease2E-2821738487
77701Rest8E-727126917
79340Parkinson Disease1E-3927182965
84055Emotions5E-627089181
85877Inflammatory Bowel Diseases3E-1528067908
90870Parkinson Disease3E-2122438815
90987Crohn Disease4E-2126192919
95749Inflammatory Bowel Diseases2E-1526192919
101510Arthritis, Juvenile3E-1026301688
101511Autoimmune Diseases3E-1026301688
101512Celiac Disease3E-1026301688
101513Colitis, Ulcerative3E-1026301688
101514Crohn Disease3E-1026301688
101515Diabetes Mellitus, Type 13E-1026301688
101516Lupus Erythematosus, Systemic3E-1026301688
101517Psoriasis3E-1026301688
101518Spondylitis, Ankylosing3E-1026301688
101519Thyroid Diseases3E-1026301688
101520Common Variable Immunodeficiency3E-1026301688

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane1IEAHomo_sapiens(9606)Component
GO:0000149enables SNARE binding2IBA,IPIHomo_sapiens(9606)Function
GO:0000165involved_in MAPK cascade1IDAHomo_sapiens(9606)Process
GO:0000287enables magnesium ion binding1IMPHomo_sapiens(9606)Function
GO:0001933involved_in negative regulation of protein phosphorylation1ISSHomo_sapiens(9606)Process
GO:0001934involved_in positive regulation of protein phosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0003779enables actin binding1IPIHomo_sapiens(9606)Function
GO:0003924enables GTPase activity1IDAHomo_sapiens(9606)Function
GO:0004672enables protein kinase activity1IDAHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity5EXP,IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0004706enables JUN kinase kinase kinase activity1IDAHomo_sapiens(9606)Function
GO:0004709enables MAP kinase kinase kinase activity1IDAHomo_sapiens(9606)Function
GO:0005096enables GTPase activator activity1IDAHomo_sapiens(9606)Function
GO:0005102enables signaling receptor binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005525enables GTP binding2IDA,TASHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1HDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,IMPHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0005741is_active_in mitochondrial outer membrane2IBA,ISSHomo_sapiens(9606)Component
GO:0005743located_in mitochondrial inner membrane1ISSHomo_sapiens(9606)Component
GO:0005759located_in mitochondrial matrix1ISSHomo_sapiens(9606)Component
GO:0005764is_active_in lysosome2IBA,ISSHomo_sapiens(9606)Component
GO:0005768is_active_in endosome2IBA,ISSHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum2IDA,ISSHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1IEAHomo_sapiens(9606)Component
GO:0005794located_in Golgi apparatus2IDA,ISSHomo_sapiens(9606)Component
GO:0005798located_in Golgi-associated vesicle1IDAHomo_sapiens(9606)Component
GO:0005802located_in trans-Golgi network1IEAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005856located_in cytoskeleton1IEAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0005902located_in microvillus1IDAHomo_sapiens(9606)Component
GO:0006468involved_in protein phosphorylation3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0006606involved_in protein import into nucleus1IEAHomo_sapiens(9606)Process
GO:0006897involved_in endocytosis2IGI,IMPHomo_sapiens(9606)Process
GO:0006914involved_in autophagy1IEAHomo_sapiens(9606)Process
GO:0006979involved_in response to oxidative stress1IMPHomo_sapiens(9606)Process
GO:0007005involved_in mitochondrion organization2IBA,IMPHomo_sapiens(9606)Process
GO:0007029involved_in endoplasmic reticulum organization2IBA,IMPHomo_sapiens(9606)Process
GO:0007030involved_in Golgi organization2IBA,IMPHomo_sapiens(9606)Process
GO:0007040involved_in lysosome organization1IMPHomo_sapiens(9606)Process
GO:0007254involved_in JNK cascade1IDAHomo_sapiens(9606)Process
GO:0007283involved_in spermatogenesis1IEAHomo_sapiens(9606)Process
GO:0007528involved_in neuromuscular junction development1IMPHomo_sapiens(9606)Process
GO:0008017enables microtubule binding1TASHomo_sapiens(9606)Function
GO:0008104involved_in protein localization1ISSHomo_sapiens(9606)Process
GO:0008340involved_in determination of adult lifespan1IMPHomo_sapiens(9606)Process
GO:0009267involved_in cellular response to starvation1IMPHomo_sapiens(9606)Process
GO:0010506involved_in regulation of autophagy1IMPHomo_sapiens(9606)Process
GO:0010508involved_in positive regulation of autophagy3IBA,IMP,ISSHomo_sapiens(9606)Process
GO:0010738involved_in regulation of protein kinase A signaling1ISSHomo_sapiens(9606)Process
GO:0010955involved_in negative regulation of protein processing1IDAHomo_sapiens(9606)Process
GO:0010977involved_in negative regulation of neuron projection development1IEAHomo_sapiens(9606)Process
GO:0014041involved_in regulation of neuron maturation1IMPHomo_sapiens(9606)Process
GO:0015631enables tubulin binding1IDAHomo_sapiens(9606)Function
GO:0016234located_in inclusion body1IMPHomo_sapiens(9606)Component
GO:0016242involved_in negative regulation of macroautophagy1IMPHomo_sapiens(9606)Process
GO:0016301enables kinase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0016310involved_in phosphorylation1IMPHomo_sapiens(9606)Process
GO:0016323is_active_in basolateral plasma membrane1IBAHomo_sapiens(9606)Component
GO:0017075enables syntaxin-1 binding1IPIHomo_sapiens(9606)Function
GO:0018105involved_in peptidyl-serine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0018107involved_in peptidyl-threonine phosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0019722involved_in calcium-mediated signaling2IBA,IMPHomo_sapiens(9606)Process
GO:0021756involved_in striatum development1IEAHomo_sapiens(9606)Process
GO:0021772involved_in olfactory bulb development1IMPHomo_sapiens(9606)Process
GO:0022028involved_in tangential migration from the subventricular zone to the olfactory bulb1IMPHomo_sapiens(9606)Process
GO:0030159enables signaling receptor complex adaptor activity1IDAHomo_sapiens(9606)Function
GO:0030276enables clathrin binding1IPIHomo_sapiens(9606)Function
GO:0030424is_active_in axon3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0030425located_in dendrite2IDA,ISSHomo_sapiens(9606)Component
GO:0030426located_in growth cone1IDAHomo_sapiens(9606)Component
GO:0030672located_in synaptic vesicle membrane1IEAHomo_sapiens(9606)Component
GO:0031267enables small GTPase binding1IPIHomo_sapiens(9606)Function
GO:0031398involved_in positive regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031410located_in cytoplasmic vesicle1ISSHomo_sapiens(9606)Component
GO:0031647involved_in regulation of protein stability1IMPHomo_sapiens(9606)Process
GO:0031966located_in mitochondrial membrane1IDAHomo_sapiens(9606)Component
GO:0032088involved_in negative regulation of NF-kappaB transcription factor activity1IBAHomo_sapiens(9606)Process
GO:0032091involved_in negative regulation of protein binding1IMPHomo_sapiens(9606)Process
GO:0032092involved_in positive regulation of protein binding1IDAHomo_sapiens(9606)Process
GO:0032436involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process1ISSHomo_sapiens(9606)Process
GO:0032473located_in cytoplasmic side of mitochondrial outer membrane1IDAHomo_sapiens(9606)Component
GO:0032760involved_in positive regulation of tumor necrosis factor production1IEAHomo_sapiens(9606)Process
GO:0032839located_in dendrite cytoplasm1IDAHomo_sapiens(9606)Component
GO:0034211enables GTP-dependent protein kinase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0034260acts_upstream_of_or_within negative regulation of GTPase activity1IDAHomo_sapiens(9606)Process
GO:0034599involved_in cellular response to oxidative stress1IMPHomo_sapiens(9606)Process
GO:0034614involved_in cellular response to reactive oxygen species1IMPHomo_sapiens(9606)Process
GO:0035556involved_in intracellular signal transduction1ISSHomo_sapiens(9606)Process
GO:0035564involved_in regulation of kidney size1ISSHomo_sapiens(9606)Process
GO:0035640involved_in exploration behavior1IMPHomo_sapiens(9606)Process
GO:0035641involved_in locomotory exploration behavior1IEAHomo_sapiens(9606)Process
GO:0035751involved_in regulation of lysosomal lumen pH1IMPHomo_sapiens(9606)Process
GO:0036479enables peroxidase inhibitor activity1IDAHomo_sapiens(9606)Function
GO:0039706enables co-receptor binding1TASHomo_sapiens(9606)Function
GO:0040012involved_in regulation of locomotion1IMPHomo_sapiens(9606)Process
GO:0042391involved_in regulation of membrane potential2IBA,IMPHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IPIHomo_sapiens(9606)Function
GO:0043005located_in neuron projection1IDAHomo_sapiens(9606)Component
GO:0043025located_in neuronal cell body1IDAHomo_sapiens(9606)Component
GO:0043068involved_in positive regulation of programmed cell death1IDAHomo_sapiens(9606)Process
GO:0043195located_in terminal bouton1TASHomo_sapiens(9606)Component
GO:0043204is_active_in perikaryon3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0043406involved_in positive regulation of MAP kinase activity2IC,IMPHomo_sapiens(9606)Process
GO:0044325enables transmembrane transporter binding1IPIHomo_sapiens(9606)Function
GO:0044753located_in amphisome1IDAHomo_sapiens(9606)Component
GO:0044754located_in autolysosome1IDAHomo_sapiens(9606)Component
GO:0045121is_active_in membrane raft1IBAHomo_sapiens(9606)Component
GO:0045860involved_in positive regulation of protein kinase activity1IDAHomo_sapiens(9606)Process
GO:0046039involved_in GTP metabolic process1IDAHomo_sapiens(9606)Process
GO:0046777involved_in protein autophosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0048312involved_in intracellular distribution of mitochondria1IMPHomo_sapiens(9606)Process
GO:0048812involved_in neuron projection morphogenesis2IBA,IMPHomo_sapiens(9606)Process
GO:0051018enables protein kinase A binding2IBA,IPIHomo_sapiens(9606)Function
GO:0051646involved_in mitochondrion localization1IMPHomo_sapiens(9606)Process
GO:0051770involved_in positive regulation of nitric-oxide synthase biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0051900involved_in regulation of mitochondrial depolarization1IMPHomo_sapiens(9606)Process
GO:0051966involved_in regulation of synaptic transmission, glutamatergic1ISSHomo_sapiens(9606)Process
GO:0060070involved_in canonical Wnt signaling pathway1TASHomo_sapiens(9606)Process
GO:0060079involved_in excitatory postsynaptic potential1ISSHomo_sapiens(9606)Process
GO:0060159involved_in regulation of dopamine receptor signaling pathway2IBA,ISSHomo_sapiens(9606)Process
GO:0060161involved_in positive regulation of dopamine receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0060628involved_in regulation of ER to Golgi vesicle-mediated transport1ISSHomo_sapiens(9606)Process
GO:0060828involved_in regulation of canonical Wnt signaling pathway2IBA,TASHomo_sapiens(9606)Process
GO:0061001involved_in regulation of dendritic spine morphogenesis2IMP,ISSHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070585involved_in protein localization to mitochondrion1TASHomo_sapiens(9606)Process
GO:0070971is_active_in endoplasmic reticulum exit site2IBA,IDAHomo_sapiens(9606)Component
GO:0070973involved_in protein localization to endoplasmic reticulum exit site2IBA,IMPHomo_sapiens(9606)Process
GO:0071287involved_in cellular response to manganese ion1IMPHomo_sapiens(9606)Process
GO:0071356involved_in cellular response to tumor necrosis factor1IBAHomo_sapiens(9606)Process
GO:0071407involved_in cellular response to organic cyclic compound1IBAHomo_sapiens(9606)Process
GO:0090140involved_in regulation of mitochondrial fission1TASHomo_sapiens(9606)Process
GO:0090263involved_in positive regulation of canonical Wnt signaling pathway1IGIHomo_sapiens(9606)Process
GO:0090394involved_in negative regulation of excitatory postsynaptic potential1ISSHomo_sapiens(9606)Process
GO:0097487located_in multivesicular body, internal vesicle1IDAHomo_sapiens(9606)Component
GO:0098794located_in postsynapse1IEAHomo_sapiens(9606)Component
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0099400located_in caveola neck1IDAHomo_sapiens(9606)Component
GO:0099523located_in presynaptic cytosol1IEAHomo_sapiens(9606)Component
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:0140058involved_in neuron projection arborization1IEAHomo_sapiens(9606)Process
GO:1900244involved_in positive regulation of synaptic vesicle endocytosis1IEAHomo_sapiens(9606)Process
GO:1901214involved_in regulation of neuron death1IMPHomo_sapiens(9606)Process
GO:1902236involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway1IMPHomo_sapiens(9606)Process
GO:1902499involved_in positive regulation of protein autoubiquitination1IDAHomo_sapiens(9606)Process
GO:1902692involved_in regulation of neuroblast proliferation1IMPHomo_sapiens(9606)Process
GO:1902803involved_in regulation of synaptic vesicle transport3IBA,ISS,TASHomo_sapiens(9606)Process
GO:1902823involved_in negative regulation of late endosome to lysosome transport1TASHomo_sapiens(9606)Process
GO:1902902involved_in negative regulation of autophagosome assembly2IBA,IMPHomo_sapiens(9606)Process
GO:1903125involved_in negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation1IDAHomo_sapiens(9606)Process
GO:1903215involved_in negative regulation of protein targeting to mitochondrion1IDAHomo_sapiens(9606)Process
GO:1903217involved_in negative regulation of protein processing involved in protein targeting to mitochondrion1ICHomo_sapiens(9606)Process
GO:1903351involved_in cellular response to dopamine1IMPHomo_sapiens(9606)Process
GO:1903980involved_in positive regulation of microglial cell activation1IEAHomo_sapiens(9606)Process
GO:1904713enables beta-catenin destruction complex binding1NASHomo_sapiens(9606)Function
GO:1904887involved_in Wnt signalosome assembly2IPI,TASHomo_sapiens(9606)Process
GO:1905279involved_in regulation of retrograde transport, endosome to Golgi2IBA,IGIHomo_sapiens(9606)Process
GO:1905289involved_in regulation of CAMKK-AMPK signaling cascade1IMPHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IEAHomo_sapiens(9606)Component
GO:1990909part_of Wnt signalosome2IDA,NASHomo_sapiens(9606)Component
GO:2000172involved_in regulation of branching morphogenesis of a nerve1IMPHomo_sapiens(9606)Process
GO:2000300involved_in regulation of synaptic vesicle exocytosis1IMPHomo_sapiens(9606)Process
GO:2000377involved_in regulation of reactive oxygen species metabolic process1IMPHomo_sapiens(9606)Process

Expression