RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq

Description

Ensembl ID	ENSG00000188039	Gene ID	284434	Accession	27619
Symbol	NWD1	Alias	NA	Full Name	NACHT and WD repeat domain containing 1
Status	Confidence	Length	98117 bases	Strand	Plus strand
Position	19 : 16719847 - 16817963	RNA binding domain	N.A.
Summary	The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
NWD1-203	ENST00000524140	7764	1432aa	ENSP00000428579
NWD1-210	ENST00000674033	1631	No protein	-
NWD1-202	ENST00000518676	8393	179aa	ENSP00000428224
NWD1-209	ENST00000673803	7788	1432aa	ENSP00000501265
NWD1-204	ENST00000549814	6614	1522aa	ENSP00000447548
NWD1-208	ENST00000673758	419	14aa	ENSP00000501179
NWD1-206	ENST00000646016	7124	76aa	ENSP00000496092
NWD1-207	ENST00000673671	7649	No protein	-
NWD1-201	ENST00000438489	6162	76aa	ENSP00000400248
NWD1-205	ENST00000552788	6964	1564aa	ENSP00000447224
NWD1-211	ENST00000674103	991	194aa	ENSP00000501011

Gene Model

Click here to download ENSG00000188039's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
75076	Bronchodilator Agents	1E-6	26503814
75077	Forced Expiratory Volume	1E-6	26503814
75078	Pulmonary Disease, Chronic Obstructive	1E-6	26503814

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000188039's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005730	located_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0010628	involved_in positive regulation of gene expression	1	IMP	Homo_sapiens(9606)	Process
GO:0032088	involved_in negative regulation of NF-kappaB transcription factor activity	1	IMP	Homo_sapiens(9606)	Process

Expression