RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000187840	Gene ID	1978	Accession	3288
Symbol	EIF4EBP1	Alias	BP-1;4EBP1;4E-BP1;PHAS-I	Full Name	eukaryotic translation initiation factor 4E binding protein 1
Status	Confidence	Length	29832 bases	Strand	Plus strand
Position	8 : 38030534 - 38060365	RNA binding domain	eIF_4EBP
Summary	This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000340691	eIF_4EBP	PF05456	5.4e-43	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
37583983	High expression of autophagy-related gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer.	Shan Yang	2023-07-16	World journal of clinical cases

Name	Transcript ID	bp	Protein	Translation ID
EIF4EBP1-201	ENST00000338825	827	118aa	ENSP00000340691
EIF4EBP1-202	ENST00000520657	695	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000082	involved_in G1/S transition of mitotic cell cycle	1	IMP	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0008190	enables eukaryotic initiation factor 4E binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0030371	enables translation repressor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0031929	involved_in TOR signaling	1	IDA	Homo_sapiens(9606)	Process
GO:0045931	involved_in positive regulation of mitotic cell cycle	1	IMP	Homo_sapiens(9606)	Process
GO:0045947	involved_in negative regulation of translational initiation	2	IBA,IDA	Homo_sapiens(9606)	Process