Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000186716 Gene ID 613 Accession 1014
Symbol BCR Alias ALL;CML;PHL;BCR1;D22S11;D22S662 Full Name BCR activator of RhoGEF and GTPase
Status Confidence Length 137673 bases Strand Plus strand
Position 22 : 23180365 - 23318037 RNA binding domain N.A.
Summary A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
15939795 Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells. Niklas Feldhahn 2005-06-06 The Journal of experimental medicine
21299458 BCR-ABL1 kinase-dependent alteration of mRNA metabolism: potential alternatives for therapeutic intervention. Danilo Perrotti 2011-02-01 Leukemia & lymphoma
23970380 Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias. J Christopher Walker 2013-10-24 Blood
28751890 TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells. N Amy Suthers 2017-01-01 Frontiers in immunology

Transcripts

Name Transcript ID bp Protein Translation ID
BCR-212 ENST00000479188 658 No protein -
BCR-202 ENST00000359540 4708 1227aa ENSP00000352535
BCR-201 ENST00000305877 6783 1271aa ENSP00000303507
BCR-207 ENST00000463770 168 No protein -
BCR-214 ENST00000487679 231 No protein -
BCR-213 ENST00000480973 535 No protein -
BCR-204 ENST00000427791 771 257aa ENSP00000396531
BCR-215 ENST00000487968 2870 No protein -
BCR-208 ENST00000466076 495 No protein -
BCR-203 ENST00000419722 788 No protein -
BCR-209 ENST00000471452 638 No protein -
BCR-211 ENST00000478978 463 No protein -
BCR-210 ENST00000475025 563 No protein -
BCR-205 ENST00000436990 4188 No protein -
BCR-206 ENST00000458056 778 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
11015Hip1.89477414576575E-617903296
46695Platelet Function Tests7.5483000E-006-
78137Vaccine Potency8E-622542470
85465coenzyme Q102E-627149984
89070Body Height6E-618391951

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002692involved_in negative regulation of cellular extravasation1IEAHomo_sapiens(9606)Process
GO:0003014involved_in renal system process1IEAHomo_sapiens(9606)Process
GO:0004674enables protein serine/threonine kinase activity1IEAHomo_sapiens(9606)Function
GO:0004713enables protein tyrosine kinase activity1TASHomo_sapiens(9606)Function
GO:0005085enables guanyl-nucleotide exchange factor activity3IDA,IMP,TASHomo_sapiens(9606)Function
GO:0005096enables GTPase activator activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IEAHomo_sapiens(9606)Component
GO:0006468involved_in protein phosphorylation1IEAHomo_sapiens(9606)Process
GO:0006909involved_in phagocytosis1IEAHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007264involved_in small GTPase mediated signal transduction1IMPHomo_sapiens(9606)Process
GO:0007420involved_in brain development1IEAHomo_sapiens(9606)Process
GO:0014069located_in postsynaptic density1IEAHomo_sapiens(9606)Component
GO:0016020located_in membrane2HDA,IBAHomo_sapiens(9606)Component
GO:0030036involved_in actin cytoskeleton organization1IEAHomo_sapiens(9606)Process
GO:0030216involved_in keratinocyte differentiation1IMPHomo_sapiens(9606)Process
GO:0030424located_in axon1IEAHomo_sapiens(9606)Component
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0035023involved_in regulation of Rho protein signal transduction1IMPHomo_sapiens(9606)Process
GO:0042472involved_in inner ear morphogenesis1IEAHomo_sapiens(9606)Process
GO:0043114involved_in regulation of vascular permeability1IEAHomo_sapiens(9606)Process
GO:0043197located_in dendritic spine1IEAHomo_sapiens(9606)Component
GO:0043312involved_in neutrophil degranulation1IEAHomo_sapiens(9606)Process
GO:0043314involved_in negative regulation of neutrophil degranulation1IEAHomo_sapiens(9606)Process
GO:0048041involved_in focal adhesion assembly1IMPHomo_sapiens(9606)Process
GO:0048872involved_in homeostasis of number of cells1IEAHomo_sapiens(9606)Process
GO:0050728involved_in negative regulation of inflammatory response1IEAHomo_sapiens(9606)Process
GO:0050766involved_in positive regulation of phagocytosis1IEAHomo_sapiens(9606)Process
GO:0050804involved_in modulation of chemical synaptic transmission1ISSHomo_sapiens(9606)Process
GO:0050885involved_in neuromuscular process controlling balance1IEAHomo_sapiens(9606)Process
GO:0051056involved_in regulation of small GTPase mediated signal transduction1TASHomo_sapiens(9606)Process
GO:0051171involved_in regulation of nitrogen compound metabolic process1IEAHomo_sapiens(9606)Process
GO:0051726involved_in regulation of cell cycle1IEAHomo_sapiens(9606)Process
GO:0060216involved_in definitive hemopoiesis1IEAHomo_sapiens(9606)Process
GO:0060268involved_in negative regulation of respiratory burst1IEAHomo_sapiens(9606)Process
GO:0060313involved_in negative regulation of blood vessel remodeling1IEAHomo_sapiens(9606)Process
GO:0065002involved_in intracellular protein transmembrane transport1IEAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0071222involved_in cellular response to lipopolysaccharide1IEAHomo_sapiens(9606)Process
GO:0090630involved_in activation of GTPase activity2IDA,IMPHomo_sapiens(9606)Process
GO:0098685located_in Schaffer collateral - CA1 synapse1ISSHomo_sapiens(9606)Component
GO:0098978located_in glutamatergic synapse1ISSHomo_sapiens(9606)Component
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1905517involved_in macrophage migration1IEAHomo_sapiens(9606)Process
GO:1905522involved_in negative regulation of macrophage migration1IEAHomo_sapiens(9606)Process
GO:2000378involved_in negative regulation of reactive oxygen species metabolic process1IEAHomo_sapiens(9606)Process

Expression