RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	Stress granucleP-bodyNucleoli
BulkPerturb-seq	DataSet_01_342

Description

Ensembl ID	ENSG00000186416	Gene ID	55922	Accession	19374
Symbol	NKRF	Alias		Full Name
Status	Confidence	Length	18107 bases	Strand	Minus strand
Position	X : 119588337 - 119606443	RNA binding domain	G-patch , R3H
Summary

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000304803	G-patch	PF01585	2.9e-13	1
ENSP00000304803	R3H	PF01424	2.6e-11	2
ENSP00000442308	G-patch	PF01585	3e-13	1
ENSP00000442308	R3H	PF01424	2.7e-11	2
ENSP00000508667	G-patch	PF01585	3.6e-13	1
ENSP00000508667	R3H	PF01424	3.4e-11	2

Showing 1 to 6 of 6 entries

RNA binding proteomes (RBPomes)

Show entries

Search:

Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
29431736	RICK_PMID29431736_Hs_HeLa.RICK	HeLa	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_HeLa	HeLa	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6

Showing 1 to 10 of 19 entries

Previous1 2Next

Literatures on RNA binding capacity

Show entries

Search:

Pubmed ID	Title	Author	Time	Journal
28115624	The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.	Indira Memet	2017-05-19	Nucleic acids research
32011671	Full-length NF-κB repressing factor contains an XRN2 binding domain.	Jana Alexandrova	2020-02-28	The Biochemical journal
32179686	Structural basis for DEAH-helicase activation by G-patch proteins.	K Michael Studer	2020-03-31	Proceedings of the National Academy of Sciences of the United States of America
32393270	LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.	Xi Jin	2020-05-11	Molecular cancer
33305682	Guanine Nucleotide-Binding Protein-Like 1 (GNL1) binds RNA G-quadruplex structures in genes associated with Parkinson's disease.	Marc-Antoine Turcotte	2021-09-01	RNA biology
34965935	LncRNA Uc003xsl.1-Mediated Activation of the NFκB/IL8 Axis Promotes Progression of Triple-Negative Breast Cancer.	Ying Xu	2022-02-15	Cancer research

Showing 1 to 6 of 6 entries

Previous1Next

Transcripts

Show entries

Search:

Name	Transcript ID	bp	Protein	Translation ID
NKRF-201	ENST00000304449	3817	690aa	ENSP00000304803
NKRF-202	ENST00000487600	390	No protein	-
NKRF-203	ENST00000542113	3351	705aa	ENSP00000442308
NKRF-204	ENST00000649446	3741	No protein	-
NKRF-205	ENST00000688521	2352	783aa	ENSP00000508667

Showing 1 to 5 of 5 entries

Previous1Next

Gene Model

Click here to download ENSG00000186416's gene model file

Phenotypes

Show entries

Search:

ensgID	Trait	pValue	Pubmed ID
12096	Amyotrophic Lateral Sclerosis	6.485E-5	17362836

Showing 1 to 1 of 1 entries

Previous1Next

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000186416's PPI file

Paralogs

Show entries

Search:

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000186416	homo_sapiens	ENSP00000394183	56.8966	37.931	homo_sapiens	ENSP00000508667	8.42912	5.61941
ENSG00000186416	homo_sapiens	ENSP00000427108	33.7931	20.5172	homo_sapiens	ENSP00000508667	25.0319	15.198

Showing 1 to 2 of 2 entries

Previous1Next

Orthologs

Show entries

Search:

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000186416	homo_sapiens	ENSP00000508667	89.1443	88.8889	nomascus_leucogenys	ENSNLEP00000036613	99.0071	98.7234
ENSG00000186416	homo_sapiens	ENSP00000508667	89.272	89.0166	pan_paniscus	ENSPPAP00000000630	99.1489	98.8652
ENSG00000186416	homo_sapiens	ENSP00000508667	89.272	88.8889	pongo_abelii	ENSPPYP00000023139	99.1489	98.7234
ENSG00000186416	homo_sapiens	ENSP00000508667	89.272	89.0166	pan_troglodytes	ENSPTRP00000078646	99.1489	98.8652
ENSG00000186416	homo_sapiens	ENSP00000508667	89.1443	88.8889	gorilla_gorilla	ENSGGOP00000046526	99.0071	98.7234
ENSG00000186416	homo_sapiens	ENSP00000508667	85.8238	76.7561	ornithorhynchus_anatinus	ENSOANP00000004132	84.7415	75.7881
ENSG00000186416	homo_sapiens	ENSP00000508667	77.5223	62.3244	sarcophilus_harrisii	ENSSHAP00000030617	74.6617	60.0246
ENSG00000186416	homo_sapiens	ENSP00000508667	78.5441	66.0281	sarcophilus_harrisii	ENSSHAP00000037881	76.6833	64.4638
ENSG00000186416	homo_sapiens	ENSP00000508667	80.2043	71.5198	sarcophilus_harrisii	ENSSHAP00000007956	82.199	73.2984
ENSG00000186416	homo_sapiens	ENSP00000508667	72.0307	64.4955	notamacropus_eugenii	ENSMEUP00000002763	82.9412	74.2647

Showing 1 to 10 of 210 entries

Previous1 2 3 4 5…21Next

Gene Ontology

Show entries

Search:

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005654	is_active_in nucleoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005730	is_active_in nucleolus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0045892	involved_in negative regulation of DNA-templated transcription	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0001671	enables ATPase activator activity	1	IDA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process

Showing 1 to 10 of 10 entries

Previous1Next

Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression