RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000185880	Gene ID	140691	Accession	17857
Symbol	TRIM69	Alias	Trif;HSD34;RNF36;HSD-34	Full Name	tripartite motif containing 69
Status	Confidence	Length	38842 bases	Strand	Plus strand
Position	15 : 44728988 - 44767829	RNA binding domain	SPRY
Summary	This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000453077	SPRY	PF00622	1.6e-15	1
ENSP00000453332	SPRY	PF00622	1.9e-15	1
ENSP00000453549	SPRY	PF00622	2.1e-15	1
ENSP00000342922	SPRY	PF00622	2.7e-15	1
ENSP00000332284	SPRY	PF00622	4.9e-15	1
ENSP00000453177	SPRY	PF00622	4.9e-15	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
TRIM69-206	ENST00000559390	2486	500aa	ENSP00000453177
TRIM69-207	ENST00000560141	3190	No protein	-
TRIM69-209	ENST00000560554	655	No protein	-
TRIM69-205	ENST00000559315	560	No protein	-
TRIM69-212	ENST00000561237	561	No protein	-
TRIM69-201	ENST00000329464	1735	500aa	ENSP00000332284
TRIM69-204	ENST00000558329	1211	279aa	ENSP00000453332
TRIM69-208	ENST00000560442	1262	296aa	ENSP00000453549
TRIM69-210	ENST00000561043	1017	263aa	ENSP00000453077
TRIM69-202	ENST00000338264	1222	341aa	ENSP00000342922
TRIM69-203	ENST00000558173	5691	No protein	-
TRIM69-211	ENST00000561170	391	130aa	ENSP00000452739

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
28900	monocyte chemoattractant protein 1 (66-77)	3.3200000E-005	-
50500	Child Development Disorders, Pervasive	1.1235100E-005	-
50505	Child Development Disorders, Pervasive	2.0652500E-006	-
50512	Child Development Disorders, Pervasive	3.4958900E-006	-
51234	Child Development Disorders, Pervasive	4.2147100E-005	-
51237	Child Development Disorders, Pervasive	1.2090600E-005	-
51238	Child Development Disorders, Pervasive	4.2577500E-005	-
51239	Child Development Disorders, Pervasive	2.6268800E-005	-
51243	Child Development Disorders, Pervasive	3.7678800E-005	-
51244	Child Development Disorders, Pervasive	2.8884900E-006	-
51248	Child Development Disorders, Pervasive	4.4338900E-006	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004842	enables ubiquitin-protein transferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006915	involved_in apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	2	IBA,IEA	Homo_sapiens(9606)	Process
GO:0016607	located_in nuclear speck	1	IDA	Homo_sapiens(9606)	Component
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0061630	enables ubiquitin protein ligase activity	1	IBA	Homo_sapiens(9606)	Function