Welcome to
RBP World!
Functions and Diseases
| RBP Type | Canonical_RBPs |
| Diseases | Disease |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | TF |
| Localizations | N.A. |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000185507 | Gene ID | 3665 | Accession | 6122 |
| Symbol | IRF7 | Alias | IMD39;IRF-7;IRF7A;IRF7B;IRF7C;IRF7H;IRF-7H | Full Name | interferon regulatory factor 7 |
| Status | Confidence | Length | 3431 bases | Strand | Minus strand |
| Position | 11 : 612553 - 615983 | RNA binding domain | IRF-3 | ||
| Summary | This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021] | ||||
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 21745419 | Cytokine disturbances in systemic lupus erythematosus. | Noam Jacob | 2011-07-06 | Arthritis research & therapy |
| 28592649 | Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross. | Richard Green | 2017-06-07 | G3 (Bethesda, Md.) |
| 21268286 | A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients. | Julien Pothlichet | 2011-03-01 | EMBO molecular medicine |
| 25445206 | Interferon regulatory factors: critical mediators of human lupus. | A Mark Jensen | 2015-02-01 | Translational research : the journal of laboratory and clinical medicine |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| IRF7-209 | ENST00000528413 | 1554 | 55aa | ENSP00000497888 |
| IRF7-203 | ENST00000397566 | 2051 | 516aa | ENSP00000380697 |
| IRF7-202 | ENST00000348655 | 1807 | 474aa | ENSP00000331803 |
| IRF7-206 | ENST00000525445 | 1923 | 503aa | ENSP00000434009 |
| IRF7-214 | ENST00000533182 | 1776 | 164aa | ENSP00000433903 |
| IRF7-204 | ENST00000397570 | 1943 | 487aa | ENSP00000380700 |
| IRF7-205 | ENST00000469048 | 1596 | 164aa | ENSP00000434607 |
| IRF7-210 | ENST00000531912 | 806 | No protein | - |
| IRF7-201 | ENST00000330243 | 1992 | 516aa | ENSP00000329411 |
| IRF7-212 | ENST00000532326 | 1604 | 185aa | ENSP00000436696 |
| IRF7-207 | ENST00000525750 | 656 | No protein | - |
| IRF7-213 | ENST00000532788 | 1019 | No protein | - |
| IRF7-208 | ENST00000527160 | 617 | No protein | - |
| IRF7-211 | ENST00000532096 | 1049 | No protein | - |
| IRF7-217 | ENST00000649187 | 745 | 154aa | ENSP00000497234 |
| IRF7-216 | ENST00000647801 | 891 | 161aa | ENSP00000497421 |
| IRF7-215 | ENST00000533190 | 806 | No protein | - |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 27376 | Hypertrophy, Left Ventricular | 6.8030000E-005 | - |
| 28006 | Diabetes Mellitus | 4.2770000E-005 | - |
| 94322 | Lupus Erythematosus, Systemic | 9E-11 | 27399966 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0000122 | involved_in negative regulation of transcription by RNA polymerase II | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0000785 | part_of chromatin | 2 | IDA,ISA | Homo_sapiens(9606) | Component |
| GO:0000978 | enables RNA polymerase II cis-regulatory region sequence-specific DNA binding | 2 | IBA,IDA | Homo_sapiens(9606) | Function |
| GO:0000981 | enables DNA-binding transcription factor activity, RNA polymerase II-specific | 3 | IBA,IDA,ISA | Homo_sapiens(9606) | Function |
| GO:0002376 | involved_in immune system process | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0002819 | involved_in regulation of adaptive immune response | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0003677 | enables DNA binding | 1 | IMP | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005634 | is_active_in nucleus | 2 | IBA,IDA | Homo_sapiens(9606) | Component |
| GO:0005654 | located_in nucleoplasm | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0005737 | located_in cytoplasm | 2 | IDA,IGI | Homo_sapiens(9606) | Component |
| GO:0005829 | located_in cytosol | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0006357 | involved_in regulation of transcription by RNA polymerase II | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0006974 | involved_in DNA damage response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0009615 | involved_in response to virus | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0010008 | located_in endosome membrane | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0016064 | involved_in immunoglobulin mediated immune response | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0019043 | involved_in establishment of viral latency | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0032479 | involved_in regulation of type I interferon production | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0032481 | involved_in positive regulation of type I interferon production | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0032727 | involved_in positive regulation of interferon-alpha production | 2 | IDA,TAS | Homo_sapiens(9606) | Process |
| GO:0032728 | involved_in positive regulation of interferon-beta production | 2 | IMP,TAS | Homo_sapiens(9606) | Process |
| GO:0034124 | involved_in regulation of MyD88-dependent toll-like receptor signaling pathway | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0034127 | involved_in regulation of MyD88-independent toll-like receptor signaling pathway | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0039530 | involved_in MDA-5 signaling pathway | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0045087 | involved_in innate immune response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0045655 | involved_in regulation of monocyte differentiation | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0045893 | involved_in positive regulation of DNA-templated transcription | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0045944 | involved_in positive regulation of transcription by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0050776 | involved_in regulation of immune response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0051607 | involved_in defense response to virus | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0060337 | involved_in type I interferon-mediated signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0060340 | involved_in positive regulation of type I interferon-mediated signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:1990837 | enables sequence-specific double-stranded DNA binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:2000110 | involved_in negative regulation of macrophage apoptotic process | 1 | TAS | Homo_sapiens(9606) | Process |