RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000185133	Gene ID	27124	Accession	8956
Symbol	INPP5J	Alias	PIPP;INPP5;PIB5PA	Full Name	inositol polyphosphate-5-phosphatase J
Status	Confidence	Length	11775 bases	Strand	Plus strand
Position	22 : 31122923 - 31134697	RNA binding domain	Exo_endo_phos
Summary	Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000383150	Exo_endo_phos	PF03372	1.2e-09	1
ENSP00000384596	Exo_endo_phos	PF03372	1.2e-09	1
ENSP00000384534	Exo_endo_phos	PF03372	1.2e-09	1
ENSP00000392924	Exo_endo_phos	PF03372	2.4e-09	1
ENSP00000333262	Exo_endo_phos	PF03372	2.7e-09	1
ENSP00000479645	Exo_endo_phos	PF03372	8.1e-08	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
INPP5J-212	ENST00000463528	526	No protein	-
INPP5J-208	ENST00000412277	3512	939aa	ENSP00000392924
INPP5J-213	ENST00000620191	2306	571aa	ENSP00000479645
INPP5J-209	ENST00000412985	805	144aa	ENSP00000401124
INPP5J-201	ENST00000331075	3348	1006aa	ENSP00000333262
INPP5J-211	ENST00000461241	2810	No protein	-
INPP5J-210	ENST00000420017	558	102aa	ENSP00000406570
INPP5J-202	ENST00000400294	2393	639aa	ENSP00000383150
INPP5J-205	ENST00000404390	2215	638aa	ENSP00000384534
INPP5J-207	ENST00000405300	2515	639aa	ENSP00000384596
INPP5J-204	ENST00000402238	1564	345aa	ENSP00000385264
INPP5J-206	ENST00000404453	1613	371aa	ENSP00000385343
INPP5J-203	ENST00000401755	1751	371aa	ENSP00000384540

Gene Model

Click here to download ENSG00000185133's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
64087	Gastrointestinal Microbiome	5E-8	27723756

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000185133's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001726	is_active_in ruffle	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0004439	enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004445	enables inositol-polyphosphate 5-phosphatase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005886	is_active_in plasma membrane	1	IBA	Homo_sapiens(9606)	Component
GO:0006661	involved_in phosphatidylinositol biosynthetic process	1	TAS	Homo_sapiens(9606)	Process
GO:0010977	involved_in negative regulation of neuron projection development	1	IEA	Homo_sapiens(9606)	Process
GO:0017124	enables SH3 domain binding	1	IEA	Homo_sapiens(9606)	Function
GO:0030426	located_in growth cone	1	IEA	Homo_sapiens(9606)	Component
GO:0033137	involved_in negative regulation of peptidyl-serine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0034485	enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	2	IBA,TAS	Homo_sapiens(9606)	Function
GO:0043198	located_in dendritic shaft	1	IEA	Homo_sapiens(9606)	Component
GO:0043647	involved_in inositol phosphate metabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0046856	involved_in phosphatidylinositol dephosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0052658	enables inositol-1,4,5-trisphosphate 5-phosphatase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0052659	enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	1	IEA	Homo_sapiens(9606)	Function

Expression