RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000185122	Gene ID	3297	Accession	5224
Symbol	HSF1	Alias	HSTF1	Full Name	heat shock transcription factor 1
Status	Confidence	Length	23130 bases	Strand	Plus strand
Position	8 : 144291591 - 144314720	RNA binding domain	N.A.
Summary	The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
31079284	Quantitative bioimage analytics enables measurement of targeted cellular stress response induced by celastrol-loaded nanoparticles.	Erik Niemelä	2019-07-01	Cell stress & chaperones
35460253	Heat shock factor 1 in fat biology: comments on 'Local hyperthermia therapy induces browning of white fat and treats obesity'.	Lingyan Xu	2022-07-27	Journal of molecular cell biology
27354066	Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.	Sharadha S Dayalan	2016-09-15	Molecular and cellular biology
28101237	Heat shock factor 2 is associated with the occurrence of lung cancer by enhancing the expression of heat shock proteins.	Yun-Hua Zhong	2016-12-01	Oncology letters
26013169	When Cancer Fights Back: Multiple Myeloma, Proteasome Inhibition, and the Heat-Shock Response.	P Shardule Shah	2015-08-01	Molecular cancer research : MCR
35456403	HSF1-Activated Non-Coding Stress Response: Satellite lncRNAs and Beyond, an Emerging Story with a Complex Scenario.	Claire Vourc'h	2022-03-27	Genes
20074381	Integrative analysis of the heat shock response in Aspergillus fumigatus.	Daniela Albrecht	2010-01-15	BMC genomics
29524129	Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities.	Dilara Sen	2018-01-01	Methods in molecular biology (Clifton, N.J.)
36203874	Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles.	Emma Lacroix	2022-01-01	Frontiers in molecular biosciences
35006040	Integrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer.	Xiaomin Ren	2022-02-01	Bioengineered
25847399	Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs.	Andrija Finka	2015-07-01	Cell stress & chaperones
23107491	Caenorhabditis elegans HSF-1 is an essential nuclear protein that forms stress granule-like structures following heat shock.	A Elizabeth Morton	2013-02-01	Aging cell
23573417	Heat shock proteins and regulatory T cells.	W E Brenu	2013-01-01	Autoimmune diseases
19671128	Selective entrainment of the Drosophila circadian clock to daily gradients in environmental temperature.	Jake Currie	2009-08-11	BMC biology
32586379	RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases.	Mahlon Collins	2020-06-26	Acta neuropathologica communications
21898224	The role of heat shock factors in stress-induced transcription.	Yue Zhang	2011-01-01	Methods in molecular biology (Clifton, N.J.)
34680920	The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model.	N Lev Porokhovnik	2021-09-28	Genes
28783244	Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway.	Ke Chen	2017-10-01	Molecular oncology
21687820	Signal Transduction Pathways Leading to Heat Shock Transcription.	K S Calderwood	2010-01-01	Signal transduction insights
22863008	HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.	L Marc Mendillo	2012-08-03	Cell
37239880	Multiplexed Gene Engineering Based on dCas9 and gRNA-tRNA Array Encoded on Single Transcript.	Chaoqian Jiang	2023-05-10	International journal of molecular sciences
35311075	Heat Shock Proteins and HSF1 in Cancer.	M Anna Cyran	2022-01-01	Frontiers in oncology
26509637	Anti-Transcription Factor RNA Aptamers as Potential Therapeutics.	Estefanía Mondragón	2016-02-01	Nucleic acid therapeutics
35294249	HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.	S Roger Smith	2022-03-18	Science advances
32609809	RNA aptamer capture of macromolecular complexes for mass spectrometry analysis.	Judhajeet Ray	2020-09-04	Nucleic acids research

Name	Transcript ID	bp	Protein	Translation ID
HSF1-201	ENST00000400780	2105	495aa	ENSP00000383590
HSF1-204	ENST00000528838	2134	529aa	ENSP00000431512
HSF1-206	ENST00000528988	775	64aa	ENSP00000481007
HSF1-212	ENST00000533240	561	138aa	ENSP00000436616
HSF1-210	ENST00000532338	3451	No protein	-
HSF1-203	ENST00000528199	659	No protein	-
HSF1-207	ENST00000529630	646	No protein	-
HSF1-213	ENST00000534314	684	91aa	ENSP00000484174
HSF1-202	ENST00000527328	2336	No protein	-
HSF1-209	ENST00000531447	364	No protein	-
HSF1-211	ENST00000533130	493	No protein	-
HSF1-208	ENST00000530661	552	47aa	ENSP00000480423
HSF1-214	ENST00000614796	1724	No protein	-
HSF1-205	ENST00000528842	935	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0000165	involved_in MAPK cascade	1	IDA	Homo_sapiens(9606)	Process
GO:0000776	located_in kinetochore	1	IDA	Homo_sapiens(9606)	Component
GO:0000785	part_of chromatin	1	ISA	Homo_sapiens(9606)	Component
GO:0000791	part_of euchromatin	1	IEA	Homo_sapiens(9606)	Component
GO:0000792	part_of heterochromatin	1	IEA	Homo_sapiens(9606)	Component
GO:0000976	enables transcription cis-regulatory region binding	1	IDA	Homo_sapiens(9606)	Function
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	2	IDA,ISA	Homo_sapiens(9606)	Function
GO:0001162	enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0001227	enables DNA-binding transcription repressor activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0003677	enables DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003700	enables DNA-binding transcription factor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	3	IBA,IDA,IMP	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005813	located_in centrosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006281	involved_in DNA repair	1	IEA	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0006397	involved_in mRNA processing	1	IEA	Homo_sapiens(9606)	Process
GO:0006952	involved_in defense response	1	IEA	Homo_sapiens(9606)	Process
GO:0007584	involved_in response to nutrient	1	IEA	Homo_sapiens(9606)	Process
GO:0010628	involved_in positive regulation of gene expression	1	IEA	Homo_sapiens(9606)	Process
GO:0010629	involved_in negative regulation of gene expression	1	IEA	Homo_sapiens(9606)	Process
GO:0010667	involved_in negative regulation of cardiac muscle cell apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0014823	involved_in response to activity	1	IEA	Homo_sapiens(9606)	Process
GO:0016605	located_in PML body	1	IDA	Homo_sapiens(9606)	Component
GO:0019901	enables protein kinase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0031072	enables heat shock protein binding	1	IDA	Homo_sapiens(9606)	Function
GO:0031333	involved_in negative regulation of protein-containing complex assembly	1	IMP	Homo_sapiens(9606)	Process
GO:0031490	enables chromatin DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0033574	involved_in response to testosterone	1	IEA	Homo_sapiens(9606)	Process
GO:0034605	involved_in cellular response to heat	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0034620	involved_in cellular response to unfolded protein	1	IDA	Homo_sapiens(9606)	Process
GO:0035865	involved_in cellular response to potassium ion	1	IEA	Homo_sapiens(9606)	Process
GO:0042531	involved_in positive regulation of tyrosine phosphorylation of STAT protein	1	IEA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	2	IDA,IPI	Homo_sapiens(9606)	Function
GO:0043280	involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0043565	enables sequence-specific DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0043621	enables protein self-association	1	IDA	Homo_sapiens(9606)	Function
GO:0045651	involved_in positive regulation of macrophage differentiation	1	IMP	Homo_sapiens(9606)	Process
GO:0045931	involved_in positive regulation of mitotic cell cycle	1	IMP	Homo_sapiens(9606)	Process
GO:0045944	acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	2	IDA	Homo_sapiens(9606)	Process
GO:0046982	enables protein heterodimerization activity	1	IDA	Homo_sapiens(9606)	Function
GO:0048471	located_in perinuclear region of cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0051028	involved_in mRNA transport	1	IEA	Homo_sapiens(9606)	Process
GO:0051091	involved_in positive regulation of DNA-binding transcription factor activity	1	IMP	Homo_sapiens(9606)	Process
GO:0051879	enables Hsp90 protein binding	1	IDA	Homo_sapiens(9606)	Function
GO:0061770	enables translation elongation factor binding	1	IDA	Homo_sapiens(9606)	Function
GO:0065003	involved_in protein-containing complex assembly	1	IDA	Homo_sapiens(9606)	Process
GO:0070301	involved_in cellular response to hydrogen peroxide	1	IEA	Homo_sapiens(9606)	Process
GO:0071222	involved_in cellular response to lipopolysaccharide	1	IEA	Homo_sapiens(9606)	Process
GO:0071276	involved_in cellular response to cadmium ion	1	IDA	Homo_sapiens(9606)	Process
GO:0071280	involved_in cellular response to copper ion	1	IDA	Homo_sapiens(9606)	Process
GO:0071392	involved_in cellular response to estradiol stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0071466	involved_in cellular response to xenobiotic stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0071480	involved_in cellular response to gamma radiation	1	IDA	Homo_sapiens(9606)	Process
GO:0072738	involved_in cellular response to diamide	1	IDA	Homo_sapiens(9606)	Process
GO:0090084	involved_in negative regulation of inclusion body assembly	1	IEA	Homo_sapiens(9606)	Process
GO:0090261	involved_in positive regulation of inclusion body assembly	1	IEA	Homo_sapiens(9606)	Process
GO:0097165	located_in nuclear stress granule	1	IDA	Homo_sapiens(9606)	Component
GO:0097431	located_in mitotic spindle pole	1	IDA	Homo_sapiens(9606)	Component
GO:0097677	enables STAT family protein binding	1	IEA	Homo_sapiens(9606)	Function
GO:0098847	enables sequence-specific single stranded DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0101031	part_of protein folding chaperone complex	1	IDA	Homo_sapiens(9606)	Component
GO:0120162	involved_in positive regulation of cold-induced thermogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0140296	enables general transcription initiation factor binding	1	IPI	Homo_sapiens(9606)	Function
GO:1900034	involved_in regulation of cellular response to heat	1	IDA	Homo_sapiens(9606)	Process
GO:1901215	involved_in negative regulation of neuron death	1	IEA	Homo_sapiens(9606)	Process
GO:1902512	involved_in positive regulation of apoptotic DNA fragmentation	1	IEA	Homo_sapiens(9606)	Process
GO:1903936	involved_in cellular response to sodium arsenite	1	IDA	Homo_sapiens(9606)	Process
GO:1904385	involved_in cellular response to angiotensin	1	IEA	Homo_sapiens(9606)	Process
GO:1904528	involved_in positive regulation of microtubule binding	1	IEA	Homo_sapiens(9606)	Process
GO:1904843	involved_in cellular response to nitroglycerin	1	IEA	Homo_sapiens(9606)	Process
GO:1904845	involved_in cellular response to L-glutamine	1	IEA	Homo_sapiens(9606)	Process
GO:1990837	enables sequence-specific double-stranded DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:1990841	enables promoter-specific chromatin binding	1	IEA	Homo_sapiens(9606)	Function
GO:1990904	part_of ribonucleoprotein complex	1	IDA	Homo_sapiens(9606)	Component
GO:1990910	involved_in response to hypobaric hypoxia	1	IEA	Homo_sapiens(9606)	Process
GO:1990911	involved_in response to psychosocial stress	1	IEA	Homo_sapiens(9606)	Process
GO:2001033	involved_in negative regulation of double-strand break repair via nonhomologous end joining	1	IMP	Homo_sapiens(9606)	Process