RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000185024	Gene ID	2972	Accession	11551
Symbol	BRF1	Alias	BRF;CFDS;hBRF;BRF-1;GTF3B;TAF3C;TAF3B2;TF3B90;TAFIII90;TFIIIB90;HEL-S-76p	Full Name	BRF1 RNA polymerase III transcription initiation factor subunit
Status	Confidence	Length	106304 bases	Strand	Minus strand
Position	14 : 105209286 - 105315589	RNA binding domain	TF_Zn_Ribbon
Summary	This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000446707	TF_Zn_Ribbon	PF08271	4.9e-14	1
ENSP00000369269	TF_Zn_Ribbon	PF08271	1e-13	1
ENSP00000448387	TF_Zn_Ribbon	PF08271	1.1e-13	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
27378302	Heat*seq: an interactive web tool for high-throughput sequencing experiment comparison with public data.	Guillaume Devailly	2016-11-01	Bioinformatics (Oxford, England)
25883140	The B-WICH chromatin-remodelling complex regulates RNA polymerase III transcription by promoting Max-dependent c-Myc binding.	Fatemeh Sadeghifar	2015-05-19	Nucleic acids research
15687258	Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.	Jens Lykke-Andersen	2005-02-01	Genes & development
15967811	Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.	Nancy Kedersha	2005-06-20	The Journal of cell biology
18326031	The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2.	Sushmit Maitra	2008-05-01	RNA (New York, N.Y.)
23637887	Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.	Pei-Yu Chiang	2013-01-01	PloS one

Name	Transcript ID	bp	Protein	Translation ID
BRF1-203	ENST00000392557	3579	473aa	ENSP00000376340
BRF1-202	ENST00000379937	3314	650aa	ENSP00000369269
BRF1-210	ENST00000547530	3671	677aa	ENSP00000448387
BRF1-209	ENST00000547374	3809	No protein	-
BRF1-221	ENST00000635152	2876	No protein	-
BRF1-205	ENST00000446501	2858	439aa	ENSP00000389859
BRF1-218	ENST00000551787	824	161aa	ENSP00000446901
BRF1-220	ENST00000619151	1530	184aa	ENSP00000480452
BRF1-207	ENST00000546997	1999	No protein	-
BRF1-201	ENST00000327359	2292	562aa	ENSP00000329029
BRF1-204	ENST00000440513	2368	584aa	ENSP00000388877
BRF1-213	ENST00000549044	521	No protein	-
BRF1-211	ENST00000547562	2405	No protein	-
BRF1-208	ENST00000547052	771	No protein	-
BRF1-214	ENST00000549655	1962	234aa	ENSP00000448723
BRF1-219	ENST00000552127	778	155aa	ENSP00000449788
BRF1-206	ENST00000546417	554	185aa	ENSP00000450258
BRF1-215	ENST00000550208	1040	45aa	ENSP00000449173
BRF1-216	ENST00000550375	1362	14aa	ENSP00000447521
BRF1-217	ENST00000550692	600	63aa	ENSP00000448823
BRF1-212	ENST00000548421	1452	208aa	ENSP00000446707

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
54300	Albumins	3.8740000E-005	-
54309	Albumins	5.0900000E-005	-
54327	Albumins	5.3380000E-005	-
65919	3-hydroxy-1-methylpropylmercapturic acid	5E-6	26053186
65920	Smoking	5E-6	26053186
98222	Mean Platelet Volume	3E-11	22139419

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000126	part_of transcription factor TFIIIB complex	2	IBA,NAS	Homo_sapiens(9606)	Component
GO:0000995	enables RNA polymerase III general transcription initiation factor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0001006	enables RNA polymerase III type 3 promoter sequence-specific DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006352	involved_in DNA-templated transcription initiation	1	IBA	Homo_sapiens(9606)	Process
GO:0006383	involved_in transcription by RNA polymerase III	1	IBA	Homo_sapiens(9606)	Process
GO:0006384	involved_in transcription initiation at RNA polymerase III promoter	1	TAS	Homo_sapiens(9606)	Process
GO:0009303	involved_in rRNA transcription	1	TAS	Homo_sapiens(9606)	Process
GO:0009304	involved_in tRNA transcription	1	TAS	Homo_sapiens(9606)	Process
GO:0017025	enables TBP-class protein binding	1	IEA	Homo_sapiens(9606)	Function
GO:0045945	involved_in positive regulation of transcription by RNA polymerase III	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0070897	involved_in transcription preinitiation complex assembly	1	IEA	Homo_sapiens(9606)	Process
GO:0097550	part_of transcription preinitiation complex	1	IBA	Homo_sapiens(9606)	Component