Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucleNucleoliNucleoli rim
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000184897 Gene ID 8971 Accession 4722
Symbol H1-10 Alias H1X;H1FX;H1.10 Full Name H1.10 linker histone
Status Confidence Length 1516 bases Strand Minus strand
Position 3 : 129314771 - 129316286 RNA binding domain N.A.
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
H1-10-201 ENST00000333762 1516 213aa ENSP00000329662
H1-10-202 ENST00000704995 1516 264aa ENSP00000516065

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000184897homo_sapiensENSP0000034450441.237127.8351homo_sapiensENSP0000032966237.558725.3521
ENSG00000184897homo_sapiensENSP0000033956646.478932.8638homo_sapiensENSP0000032966246.478932.8638
ENSG00000184897homo_sapiensENSP0000034121440.579722.7053homo_sapiensENSP0000032966239.436622.0657
ENSG00000184897homo_sapiensENSP0000031979926.011615.3179homo_sapiensENSP0000032966242.253524.8826
ENSG00000184897homo_sapiensENSP0000033480527.058813.7255homo_sapiensENSP0000032966232.394416.4319
ENSG00000184897homo_sapiensENSP0000024457347.441934.4186homo_sapiensENSP0000032966247.887334.7418
ENSG00000184897homo_sapiensENSP0000033007446.017733.6283homo_sapiensENSP0000032966248.826335.6808
ENSG00000184897homo_sapiensENSP0000030770548.401834.7032homo_sapiensENSP0000032966249.765335.6808
ENSG00000184897homo_sapiensENSP0000024453447.511333.4842homo_sapiensENSP0000032966249.295834.7418

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000184897homo_sapiensENSP0000032966297.652697.1831nomascus_leucogenysENSNLEP0000002313998.578298.1043
ENSG00000184897homo_sapiensENSP0000032966299.530599.5305pongo_abeliiENSPPYP0000001500899.530599.5305
ENSG00000184897homo_sapiensENSP0000032966299.06199.061pan_troglodytesENSPTRP0000002648599.06199.061
ENSG00000184897homo_sapiensENSP0000032966299.530599.061gorilla_gorillaENSGGOP0000001651799.530599.061
ENSG00000184897homo_sapiensENSP0000032966280.751272.77notamacropus_eugeniiENSMEUP0000001248882.296774.1627
ENSG00000184897homo_sapiensENSP0000032966270.422562.4413dasypus_novemcinctusENSDNOP0000001847371.770363.6364
ENSG00000184897homo_sapiensENSP0000032966278.403874.6479echinops_telfairiENSETEP0000001091283.579.5
ENSG00000184897homo_sapiensENSP0000032966297.652697.6526callithrix_jacchusENSCJAP0000006525397.196397.1963
ENSG00000184897homo_sapiensENSP0000032966299.06199.061cercocebus_atysENSCATP0000000047399.06199.061
ENSG00000184897homo_sapiensENSP0000032966299.06199.061macaca_mulattaENSMMUP0000005610499.06199.061
ENSG00000184897homo_sapiensENSP0000032966299.06199.061macaca_nemestrinaENSMNEP0000000560499.06199.061
ENSG00000184897homo_sapiensENSP0000032966299.06199.061papio_anubisENSPANP0000001066999.06199.061
ENSG00000184897homo_sapiensENSP0000032966292.488389.6714vulpes_vulpesENSVVUP0000002497892.488389.6714
ENSG00000184897homo_sapiensENSP0000032966277.464869.4836mus_spretusMGP_SPRETEiJ_P007786887.76678.7234
ENSG00000184897homo_sapiensENSP0000032966286.854583.5681equus_asinusENSEASP0000504359341.950140.3628
ENSG00000184897homo_sapiensENSP0000032966294.835792.0188panthera_leoENSPLOP0000000514995.28392.4528
ENSG00000184897homo_sapiensENSP0000032966264.788756.338ailuropoda_melanoleucaENSAMEP0000003470832.624128.3688
ENSG00000184897homo_sapiensENSP0000032966293.896791.0798bos_indicus_hybridENSBIXP0000504522193.457990.6542
ENSG00000184897homo_sapiensENSP0000032966286.854583.5681equus_caballusENSECAP0000006141246.482444.7236
ENSG00000184897homo_sapiensENSP0000032966292.018889.2019canis_lupus_familiarisENSCAFP0084502721592.018889.2019
ENSG00000184897homo_sapiensENSP0000032966295.305292.4883panthera_pardusENSPPRP0000001975495.305292.4883
ENSG00000184897homo_sapiensENSP0000032966293.896790.1408balaenoptera_musculusENSBMSP0001001718193.896790.1408
ENSG00000184897homo_sapiensENSP0000032966268.075161.9718cavia_porcellusENSCPOP0000002061178.378471.3513
ENSG00000184897homo_sapiensENSP0000032966295.305292.4883felis_catusENSFCAP0000004415895.305292.4883
ENSG00000184897homo_sapiensENSP0000032966296.244193.4272ursus_americanusENSUAMP0000002425796.244193.4272
ENSG00000184897homo_sapiensENSP0000032966279.812271.831monodelphis_domesticaENSMODP0000001013174.235866.8122
ENSG00000184897homo_sapiensENSP0000032966292.488389.6714bison_bison_bisonENSBBBP0000002463892.488389.6714
ENSG00000184897homo_sapiensENSP0000032966293.427289.6714monodon_monocerosENSMMNP0001501817593.427289.6714
ENSG00000184897homo_sapiensENSP0000032966292.488389.6714sus_scrofaENSSSCP0000008131692.056189.2523
ENSG00000184897homo_sapiensENSP0000032966269.483661.9718microcebus_murinusENSMICP0000005008071.497663.7681
ENSG00000184897homo_sapiensENSP0000032966293.427290.6103ovis_aries_rambouilletENSOARP0002002129392.990790.1869
ENSG00000184897homo_sapiensENSP0000032966293.427289.6714delphinapterus_leucasENSDLEP0000001422693.427289.6714
ENSG00000184897homo_sapiensENSP0000032966293.896790.1408physeter_catodonENSPCTP0000501997293.896790.1408
ENSG00000184897homo_sapiensENSP0000032966276.995369.4836mus_caroliMGP_CAROLIEiJ_P007488787.23478.7234
ENSG00000184897homo_sapiensENSP0000032966276.995369.4836mus_musculusENSMUSP0000015953468.619261.9247
ENSG00000184897homo_sapiensENSP0000032966296.713696.2441aotus_nancymaaeENSANAP0000000109296.261795.7944
ENSG00000184897homo_sapiensENSP0000032966292.957792.4883saimiri_boliviensis_boliviensisENSSBOP0000000587296.585496.0976
ENSG00000184897homo_sapiensENSP0000032966299.06199.061chlorocebus_sabaeusENSCSAP0000001833199.06199.061
ENSG00000184897homo_sapiensENSP0000032966276.056368.5446mesocricetus_auratusENSMAUP0000000863687.096878.4946
ENSG00000184897homo_sapiensENSP0000032966293.427289.6714phocoena_sinusENSPSNP0000003149793.427289.6714
ENSG00000184897homo_sapiensENSP0000032966293.896790.6103camelus_dromedariusENSCDRP0000501493693.896790.6103
ENSG00000184897homo_sapiensENSP0000032966276.525868.5446rattus_norvegicusENSRNOP0000003288284.895876.0417
ENSG00000184897homo_sapiensENSP0000032966269.95362.9108prolemur_simusENSPSMP0000000248072.330165.0485
ENSG00000184897homo_sapiensENSP0000032966271.361564.7887peromyscus_maniculatus_bairdiiENSPEMP0000003609486.363678.4091
ENSG00000184897homo_sapiensENSP0000032966275.117468.5446cricetulus_griseus_chok1gshdENSCGRP0000101543686.021578.4946
ENSG00000184897homo_sapiensENSP0000032966280.751270.4225vombatus_ursinusENSVURP0001002167975.109265.5022
ENSG00000184897homo_sapiensENSP0000032966290.610385.446rhinolophus_ferrumequinumENSRFEP0001000904791.904886.6667
ENSG00000184897homo_sapiensENSP0000032966295.305292.4883neovison_visonENSNVIP0000002365995.305292.4883
ENSG00000184897homo_sapiensENSP0000032966293.896791.0798bos_taurusENSBTAP0000004991093.457990.6542
ENSG00000184897homo_sapiensENSP0000032966299.530599.5305rhinopithecus_bietiENSRBIP0000000576399.530599.5305
ENSG00000184897homo_sapiensENSP0000032966292.018889.2019canis_lupus_dingoENSCAFP0002000594392.018889.2019
ENSG00000184897homo_sapiensENSP0000032966282.629173.7089sciurus_vulgarisENSSVLP0000501581181.860573.0233
ENSG00000184897homo_sapiensENSP0000032966283.098672.77phascolarctos_cinereusENSPCIP0000000034079.729769.8198
ENSG00000184897homo_sapiensENSP0000032966293.896791.0798bos_grunniensENSBGRP0000002085449.1447.6658
ENSG00000184897homo_sapiensENSP0000032966280.281772.3005chinchilla_lanigeraENSCLAP0000001205787.692378.9744
ENSG00000184897homo_sapiensENSP0000032966292.488389.2019cervus_hanglu_yarkandensisENSCHYP0000002828492.488389.2019
ENSG00000184897homo_sapiensENSP0000032966292.018888.7324catagonus_wagneriENSCWAP0000002538291.588888.3178
ENSG00000184897homo_sapiensENSP0000032966292.018888.7324otolemur_garnettiiENSOGAP0000001682987.892484.7534
ENSG00000184897homo_sapiensENSP0000032966297.652697.6526cebus_imitatorENSCCAP0000000211997.196397.1963
ENSG00000184897homo_sapiensENSP0000032966274.178467.6056urocitellus_parryiiENSUPAP0001000598272.811166.3594
ENSG00000184897homo_sapiensENSP0000032966293.896791.0798moschus_moschiferusENSMMSP0000003158593.457990.6542
ENSG00000184897homo_sapiensENSP0000032966297.652697.1831rhinopithecus_roxellanaENSRROP0000000160499.521599.0431
ENSG00000184897homo_sapiensENSP0000032966276.995369.4836mus_pahariMGP_PahariEiJ_P005101986.772578.3069
ENSG00000184897homo_sapiensENSP0000032966275.117468.0751propithecus_coquereliENSPCOP0000000412079.207971.7822
ENSG00000184897homo_sapiensENSP0000032966233.802826.7606caenorhabditis_elegansF59A7.4.137.894730
ENSG00000184897homo_sapiensENSP0000032966236.150228.169caenorhabditis_elegansY73B6BL.9a.140.314131.4136
ENSG00000184897homo_sapiensENSP0000032966240.845131.4554caenorhabditis_elegansF22F1.1.141.826932.2115
ENSG00000184897homo_sapiensENSP0000032966243.66228.6385caenorhabditis_elegansC18G1.5.136.758924.1107
ENSG00000184897homo_sapiensENSP0000032966240.845129.5775caenorhabditis_elegansB0414.3.138.666728
ENSG00000184897homo_sapiensENSP0000032966248.826335.2113eptatretus_burgeriENSEBUP0000002355949.760835.8852
ENSG00000184897homo_sapiensENSP0000032966244.600935.2113callorhinchus_miliiENSCMIP0000004739156.21344.3787
ENSG00000184897homo_sapiensENSP0000032966252.112745.0704latimeria_chalumnaeENSLACP0000001814551.869244.8598
ENSG00000184897homo_sapiensENSP0000032966256.807546.9484latimeria_chalumnaeENSLACP0000002354536.445830.1205
ENSG00000184897homo_sapiensENSP0000032966260.563447.8873clupea_harengusENSCHAP0000004015156.331944.5415
ENSG00000184897homo_sapiensENSP0000032966253.521143.1925danio_rerioENSDARP0000007067759.37547.9167
ENSG00000184897homo_sapiensENSP0000032966255.399144.6009carassius_auratusENSCARP0000010974157.843146.5686
ENSG00000184897homo_sapiensENSP0000032966253.990643.1925astyanax_mexicanusENSAMXP0000004786455.555644.4444
ENSG00000184897homo_sapiensENSP0000032966255.868545.0704ictalurus_punctatusENSIPUP0000002539658.620747.2906
ENSG00000184897homo_sapiensENSP0000032966252.582238.9671esox_luciusENSELUP0000001695059.259343.9153
ENSG00000184897homo_sapiensENSP0000032966251.643240.8451electrophorus_electricusENSEEEP0000001816858.823546.5241
ENSG00000184897homo_sapiensENSP0000032966253.990640.8451oncorhynchus_kisutchENSOKIP0000501349959.895845.3125
ENSG00000184897homo_sapiensENSP0000032966256.807542.2535oncorhynchus_mykissENSOMYP0000011909862.371146.3918
ENSG00000184897homo_sapiensENSP0000032966255.868541.3146salmo_salarENSSSAP0000014935365.745948.6188
ENSG00000184897homo_sapiensENSP0000032966256.33842.2535salmo_truttaENSSTUP0000004876261.538546.1538
ENSG00000184897homo_sapiensENSP0000032966267.605657.277xenopus_tropicalisENSXETP0000011788461.538552.1368
ENSG00000184897homo_sapiensENSP0000032966277.464868.5446chrysemys_picta_belliiENSCPBP0000001993376.036967.2811
ENSG00000184897homo_sapiensENSP0000032966276.056368.5446crocodylus_porosusENSCPRP0000502619973.303266.0633
ENSG00000184897homo_sapiensENSP0000032966273.708966.6667laticauda_laticaudataENSLLTP0000000624564.87658.6777
ENSG00000184897homo_sapiensENSP0000032966274.178466.6667notechis_scutatusENSNSUP0000002852370.222263.1111
ENSG00000184897homo_sapiensENSP0000032966275.117467.6056pseudonaja_textilisENSPTXP0000000483571.428664.2857
ENSG00000184897homo_sapiensENSP0000032966267.136157.7465gallus_gallusENSGALP0001004040335.572130.597
ENSG00000184897homo_sapiensENSP0000032966254.460151.1737meleagris_gallopavoENSMGAP0000002039284.05878.9855
ENSG00000184897homo_sapiensENSP0000032966253.990651.1737serinus_canariaENSSCAP0000000264481.560377.305
ENSG00000184897homo_sapiensENSP0000032966275.586968.5446parus_majorENSPMJP0000001698573.853266.9725
ENSG00000184897homo_sapiensENSP0000032966273.239467.1361podarcis_muralisENSPMRP0000001645369.642963.8393
ENSG00000184897homo_sapiensENSP0000032966273.239467.1361taeniopygia_guttataENSTGUP0000003374672.558166.5116
ENSG00000184897homo_sapiensENSP0000032966261.971851.6432erpetoichthys_calabaricusENSECRP0000003353466.666755.5556
ENSG00000184897homo_sapiensENSP0000032966273.239466.6667salvator_merianaeENSSMRP0000002738469.026662.8319
ENSG00000184897homo_sapiensENSP0000032966268.075157.277pelodiscus_sinensisENSPSIP0000000173876.719664.5503
ENSG00000184897homo_sapiensENSP0000032966276.995368.5446gopherus_evgoodeiENSGEVP0000502834975.57667.2811
ENSG00000184897homo_sapiensENSP0000032966277.464869.0141chelonoidis_abingdoniiENSCABP0000000681376.036967.7419
ENSG00000184897homo_sapiensENSP0000032966269.014159.1549anser_brachyrhynchusENSABRP0000001057364.192155.0218
ENSG00000184897homo_sapiensENSP0000032966276.525869.4836strigops_habroptilaENSSHBP0000502197674.770667.8899
ENSG00000184897homo_sapiensENSP0000032966276.525868.0751terrapene_carolina_triunguisENSTMTP0000001476875.115266.8203
ENSG00000184897homo_sapiensENSP0000032966254.929640.8451hucho_huchoENSHHUP000000765136044.6154
ENSG00000184897homo_sapiensENSP0000032966256.807548.8263pygocentrus_nattereriENSPNAP0000001097859.605951.2315
ENSG00000184897homo_sapiensENSP0000032966255.399142.2535oncorhynchus_tshawytschaENSOTSP0000505715661.458346.875
ENSG00000184897homo_sapiensENSP0000032966276.995369.4836aquila_chrysaetos_chrysaetosENSACCP0002001318174.885867.5799
ENSG00000184897homo_sapiensENSP0000032966244.131534.7418denticeps_clupeoidesENSDCDP0000000318065.277851.3889
ENSG00000184897homo_sapiensENSP0000032966272.300565.2582ficedula_albicollisENSFALP0000001731353.846248.6014
ENSG00000184897homo_sapiensENSP0000032966254.929644.1315cyprinus_carpio_carpioENSCCRP0000012932657.073245.8537
ENSG00000184897homo_sapiensENSP0000032966274.647967.6056coturnix_japonicaENSCJPP0000501703773.953566.9767
ENSG00000184897homo_sapiensENSP0000032966255.399144.1315sinocyclocheilus_grahamiENSSGRP000000585675947
ENSG00000184897homo_sapiensENSP0000032966256.33845.0704sinocyclocheilus_grahamiENSSGRP0000006137658.823547.0588
ENSG00000184897homo_sapiensENSP0000032966256.807545.0704paramormyrops_kingsleyaeENSPKIP0000000805960.548
ENSG00000184897homo_sapiensENSP0000032966259.624446.0094paramormyrops_kingsleyaeENSPKIP0000001070164.46749.7462
ENSG00000184897homo_sapiensENSP0000032966262.441349.7653scleropages_formosusENSSFOP0001503320754.06543.0894
ENSG00000184897homo_sapiensENSP0000032966261.502348.8263scleropages_formosusENSSFOP0001506082453.25242.2764
ENSG00000184897homo_sapiensENSP0000032966256.33845.5399leptobrachium_leishanenseENSLLEP0000002284865.217452.7174

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000786part_of nucleosome1IEAHomo_sapiens(9606)Component
GO:0003690enables double-stranded DNA binding1IBAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0006334involved_in nucleosome assembly1IEAHomo_sapiens(9606)Process
GO:0030261involved_in chromosome condensation1IBAHomo_sapiens(9606)Process
GO:0030527enables structural constituent of chromatin1IEAHomo_sapiens(9606)Function
GO:0031492enables nucleosomal DNA binding1IBAHomo_sapiens(9606)Function
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0045910involved_in negative regulation of DNA recombination1IBAHomo_sapiens(9606)Process

Expression