RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000184735	Gene ID	168400	Accession	20083
Symbol	DDX53	Alias	CAGE;CT26	Full Name	DEAD-box helicase 53
Status	Confidence	Length	3630 bases	Strand	Plus strand
Position	X : 22999960 - 23003589	RNA binding domain	DEAD , KH_1
Summary	This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000368667	DEAD	PF00270	1.6e-42	1
ENSP00000368667	KH_1	PF00013	8.7e-11	2

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32077621	Glycyrrhizic-Acid-Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms.	Ting Tong	2020-04-01	Small (Weinheim an der Bergstrasse, Germany)

Name	Transcript ID	bp	Protein	Translation ID
DDX53-201	ENST00000327968	3630	631aa	ENSP00000368667

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000184735	homo_sapiens	ENSP00000379475	48.5981	25.2336	homo_sapiens	ENSP00000368667	32.9636	17.1157
ENSG00000184735	homo_sapiens	ENSP00000385536	39.9177	28.8066	homo_sapiens	ENSP00000368667	46.1173	33.2805
ENSG00000184735	homo_sapiens	ENSP00000263239	34.4776	19.403	homo_sapiens	ENSP00000368667	36.6086	20.6022
ENSG00000184735	homo_sapiens	ENSP00000497641	46.7153	28.2238	homo_sapiens	ENSP00000368667	30.4279	18.3835
ENSG00000184735	homo_sapiens	ENSP00000482680	31.634	18.5621	homo_sapiens	ENSP00000368667	38.3518	22.504
ENSG00000184735	homo_sapiens	ENSP00000293831	48.7685	29.064	homo_sapiens	ENSP00000368667	31.3788	18.7005
ENSG00000184735	homo_sapiens	ENSP00000306117	41.2134	21.7573	homo_sapiens	ENSP00000368667	31.2203	16.4818
ENSG00000184735	homo_sapiens	ENSP00000288071	41.1273	21.7119	homo_sapiens	ENSP00000368667	31.2203	16.4818
ENSG00000184735	homo_sapiens	ENSP00000481495	28.1723	15.9488	homo_sapiens	ENSP00000368667	38.3518	21.7116
ENSG00000184735	homo_sapiens	ENSP00000416534	29.0698	17.0543	homo_sapiens	ENSP00000368667	47.5436	27.8922
ENSG00000184735	homo_sapiens	ENSP00000361232	29.3566	16.3539	homo_sapiens	ENSP00000368667	34.7068	19.3344
ENSG00000184735	homo_sapiens	ENSP00000492643	15.188	7.89474	homo_sapiens	ENSP00000368667	32.0127	16.6403
ENSG00000184735	homo_sapiens	ENSP00000238146	31.6667	18.5	homo_sapiens	ENSP00000368667	30.1109	17.5911
ENSG00000184735	homo_sapiens	ENSP00000225792	47.557	33.7134	homo_sapiens	ENSP00000368667	46.2758	32.8051
ENSG00000184735	homo_sapiens	ENSP00000330460	38.7722	21.0016	homo_sapiens	ENSP00000368667	38.0349	20.6022
ENSG00000184735	homo_sapiens	ENSP00000263576	37.4741	21.5321	homo_sapiens	ENSP00000368667	28.6846	16.4818
ENSG00000184735	homo_sapiens	ENSP00000380495	30.6306	17.2673	homo_sapiens	ENSP00000368667	32.3296	18.225
ENSG00000184735	homo_sapiens	ENSP00000314348	23.5429	13.7143	homo_sapiens	ENSP00000368667	32.6466	19.0174
ENSG00000184735	homo_sapiens	ENSP00000346120	31.0345	18.1354	homo_sapiens	ENSP00000368667	38.5103	22.504
ENSG00000184735	homo_sapiens	ENSP00000374574	33.049	19.936	homo_sapiens	ENSP00000368667	49.1284	29.6355
ENSG00000184735	homo_sapiens	ENSP00000358716	23.7864	13.835	homo_sapiens	ENSP00000368667	31.0618	18.0666
ENSG00000184735	homo_sapiens	ENSP00000442266	41.2008	24.4306	homo_sapiens	ENSP00000368667	31.5372	18.7005
ENSG00000184735	homo_sapiens	ENSP00000362687	30.6649	17.232	homo_sapiens	ENSP00000368667	35.8162	20.1268
ENSG00000184735	homo_sapiens	ENSP00000479504	39.7329	23.7062	homo_sapiens	ENSP00000368667	37.7179	22.504
ENSG00000184735	homo_sapiens	ENSP00000359361	74.6914	59.1049	homo_sapiens	ENSP00000368667	76.7036	60.6973
ENSG00000184735	homo_sapiens	ENSP00000326381	48.403	29.2383	homo_sapiens	ENSP00000368667	31.2203	18.859
ENSG00000184735	homo_sapiens	ENSP00000258772	33.638	18.83	homo_sapiens	ENSP00000368667	29.1601	16.3233
ENSG00000184735	homo_sapiens	ENSP00000494040	38.0665	23.2628	homo_sapiens	ENSP00000368667	39.9366	24.4057
ENSG00000184735	homo_sapiens	ENSP00000336725	38.0303	22.7273	homo_sapiens	ENSP00000368667	39.7781	23.7718
ENSG00000184735	homo_sapiens	ENSP00000247003	40.9938	24.4306	homo_sapiens	ENSP00000368667	31.3788	18.7005
ENSG00000184735	homo_sapiens	ENSP00000330349	37.7813	24.9196	homo_sapiens	ENSP00000368667	37.2425	24.5642
ENSG00000184735	homo_sapiens	ENSP00000242776	48.7119	25.5269	homo_sapiens	ENSP00000368667	32.9636	17.2742
ENSG00000184735	homo_sapiens	ENSP00000233084	30.2703	16.0811	homo_sapiens	ENSP00000368667	35.4992	18.859
ENSG00000184735	homo_sapiens	ENSP00000304072	27.3553	14.5289	homo_sapiens	ENSP00000368667	38.1933	20.2853
ENSG00000184735	homo_sapiens	ENSP00000350698	42.6374	27.2527	homo_sapiens	ENSP00000368667	30.7449	19.6513
ENSG00000184735	homo_sapiens	ENSP00000310723	31.9512	18.9024	homo_sapiens	ENSP00000368667	41.5214	24.5642
ENSG00000184735	homo_sapiens	ENSP00000332340	38.3333	22.2222	homo_sapiens	ENSP00000368667	32.8051	19.0174
ENSG00000184735	homo_sapiens	ENSP00000424838	34.6685	21.547	homo_sapiens	ENSP00000368667	39.7781	24.7227

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000184735	homo_sapiens	ENSP00000368667	98.2567	96.8304	pan_paniscus	ENSPPAP00000001516	98.2567	96.8304
ENSG00000184735	homo_sapiens	ENSP00000368667	96.038	94.7702	pongo_abelii	ENSPPYP00000022587	96.3434	95.0715
ENSG00000184735	homo_sapiens	ENSP00000368667	98.2567	96.5135	pan_troglodytes	ENSPTRP00000047475	98.2567	96.5135
ENSG00000184735	homo_sapiens	ENSP00000368667	93.9778	90.1743	macaca_fascicularis	ENSMFAP00000052478	93.8291	90.0316
ENSG00000184735	homo_sapiens	ENSP00000368667	93.8193	90.0158	macaca_mulatta	ENSMMUP00000065227	93.6709	89.8734
ENSG00000184735	homo_sapiens	ENSP00000368667	93.1854	88.9065	papio_anubis	ENSPANP00000055926	93.038	88.7658
ENSG00000184735	homo_sapiens	ENSP00000368667	93.8193	89.6989	chlorocebus_sabaeus	ENSCSAP00000019039	93.6709	89.557
ENSG00000184735	homo_sapiens	ENSP00000368667	81.2995	68.3043	cervus_hanglu_yarkandensis	ENSCHYP00000034059	81.0427	68.0885
ENSG00000184735	homo_sapiens	ENSP00000368667	88.1141	81.6165	cebus_imitator	ENSCCAP00000012745	88.535	82.0064
ENSG00000184735	homo_sapiens	ENSP00000368667	88.1141	81.6165	cebus_imitator	ENSCCAP00000007549	88.535	82.0064

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0003724	enables RNA helicase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0016887	enables ATP hydrolysis activity	1	IEA	Homo_sapiens(9606)	Function
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component