RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000184343	Gene ID	26576	Accession	11402
Symbol	SRPK3	Alias	MSSK1;STK23;MSSK-1	Full Name	SRSF protein kinase 3
Status	Confidence	Length	9321 bases	Strand	Plus strand
Position	X : 153776412 - 153785732	RNA binding domain	N.A.
Summary	This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
26990090	ATP1A3 Mutation in Adult Rapid-Onset Ataxia.	J Kathleen Sweadner	2016-01-01	PloS one
34019655	KEA3: improved kinase enrichment analysis via data integration.	V Maxim Kuleshov	2021-07-02	Nucleic acids research

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
SRPK3-208	ENST00000489426	4479	634aa	ENSP00000420058
SRPK3-205	ENST00000393786	1900	533aa	ENSP00000377376
SRPK3-203	ENST00000370104	1753	566aa	ENSP00000359122
SRPK3-204	ENST00000370108	1863	534aa	ENSP00000359126
SRPK3-202	ENST00000370101	1960	567aa	ENSP00000359119
SRPK3-206	ENST00000430541	614	205aa	ENSP00000402300
SRPK3-201	ENST00000370100	1717	492aa	ENSP00000359118
SRPK3-207	ENST00000458681	386	129aa	ENSP00000406166

Gene Model

Click here to download ENSG00000184343's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000184343's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000245	involved_in spliceosomal complex assembly	1	IBA	Homo_sapiens(9606)	Process
GO:0004674	enables protein serine/threonine kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005575	is_active_in cellular_component	1	ND	Homo_sapiens(9606)	Component
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0007519	involved_in skeletal muscle tissue development	1	IEA	Homo_sapiens(9606)	Process
GO:0018105	involved_in peptidyl-serine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0030154	involved_in cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	1	IBA	Homo_sapiens(9606)	Process
GO:0050684	involved_in regulation of mRNA processing	1	IBA	Homo_sapiens(9606)	Process
GO:0060537	involved_in muscle tissue development	1	ISS	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function

Expression