Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000184009 Gene ID 71 Accession 144
Symbol ACTG1 Alias ACT;ACTG;DFNA20;DFNA26;HEL-176 Full Name actin gamma 1
Status Confidence Length 14435 bases Strand Minus strand
Position 17 : 81509413 - 81523847 RNA binding domain N.A.
Summary Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ACTG1-223 ENST00000681052 2491 375aa ENSP00000505060
ACTG1-213 ENST00000576544 1880 375aa ENSP00000461672
ACTG1-205 ENST00000573283 1919 375aa ENSP00000458435
ACTG1-225 ENST00000681842 1859 375aa ENSP00000506126
ACTG1-218 ENST00000679480 1919 375aa ENSP00000506201
ACTG1-201 ENST00000570382 2052 375aa ENSP00000466346
ACTG1-215 ENST00000615544 1895 375aa ENSP00000477968
ACTG1-222 ENST00000680727 1842 375aa ENSP00000505193
ACTG1-221 ENST00000680227 1860 375aa ENSP00000506253
ACTG1-224 ENST00000681092 1749 59aa ENSP00000506720
ACTG1-206 ENST00000574671 2241 No protein -
ACTG1-212 ENST00000576214 1993 No protein -
ACTG1-217 ENST00000679410 1895 No protein -
ACTG1-220 ENST00000679778 2185 375aa ENSP00000505235
ACTG1-204 ENST00000572105 2005 198aa ENSP00000462823
ACTG1-219 ENST00000679535 2141 No protein -
ACTG1-209 ENST00000575842 2256 375aa ENSP00000458162
ACTG1-214 ENST00000576917 1958 No protein -
ACTG1-211 ENST00000576209 1698 No protein -
ACTG1-207 ENST00000575087 2001 375aa ENSP00000459124
ACTG1-216 ENST00000644774 1137 366aa ENSP00000493648
ACTG1-203 ENST00000571721 1449 375aa ENSP00000460660
ACTG1-202 ENST00000571691 1128 351aa ENSP00000461407
ACTG1-208 ENST00000575659 1228 375aa ENSP00000459119
ACTG1-210 ENST00000575994 1340 375aa ENSP00000460464

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001525acts_upstream_of_or_within_positive_effect angiogenesis1IMPHomo_sapiens(9606)Process
GO:0001738involved_in morphogenesis of a polarized epithelium1IMPHomo_sapiens(9606)Process
GO:0001895involved_in retina homeostasis1HEPHomo_sapiens(9606)Process
GO:0005200enables structural constituent of cytoskeleton1ICHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005522enables profilin binding1IDAHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1HDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus1HDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005856located_in cytoskeleton2ISS,TASHomo_sapiens(9606)Component
GO:0005884is_active_in actin filament2IBA,IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane2ISS,TASHomo_sapiens(9606)Component
GO:0005911located_in cell-cell junction1IDAHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1ISSHomo_sapiens(9606)Component
GO:0007409involved_in axonogenesis1IBAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane2HDA,IBAHomo_sapiens(9606)Component
GO:0016787enables hydrolase activity1IEAHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding1IBAHomo_sapiens(9606)Function
GO:0030016located_in myofibril1IEAHomo_sapiens(9606)Component
GO:0030335involved_in positive regulation of cell migration1IMPHomo_sapiens(9606)Process
GO:0030424is_active_in axon1IBAHomo_sapiens(9606)Component
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0031941part_of filamentous actin1IEAHomo_sapiens(9606)Component
GO:0035267part_of NuA4 histone acetyltransferase complex1IBAHomo_sapiens(9606)Component
GO:0035633acts_upstream_of_or_within maintenance of blood-brain barrier1NASHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043296located_in apical junction complex1IDAHomo_sapiens(9606)Component
GO:0044305located_in calyx of Held1IEAHomo_sapiens(9606)Component
GO:0045202is_active_in synapse1IBAHomo_sapiens(9606)Component
GO:0045214involved_in sarcomere organization1IEAHomo_sapiens(9606)Process
GO:0045335located_in phagocytic vesicle1IEAHomo_sapiens(9606)Component
GO:0048870involved_in cell motility1IBAHomo_sapiens(9606)Process
GO:0051492involved_in regulation of stress fiber assembly1IMPHomo_sapiens(9606)Process
GO:0051893involved_in regulation of focal adhesion assembly1IMPHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome2HDA,IDAHomo_sapiens(9606)Component
GO:0070527involved_in platelet aggregation1HMPHomo_sapiens(9606)Process
GO:0071346involved_in cellular response to type II interferon1IEAHomo_sapiens(9606)Process
GO:0072562located_in blood microparticle1HDAHomo_sapiens(9606)Component
GO:0090303involved_in positive regulation of wound healing1IMPHomo_sapiens(9606)Process
GO:0097433located_in dense body1ISSHomo_sapiens(9606)Component
GO:0098685located_in Schaffer collateral - CA1 synapse1IEAHomo_sapiens(9606)Component
GO:0098973enables structural constituent of postsynaptic actin cytoskeleton1IBAHomo_sapiens(9606)Function
GO:0098974involved_in postsynaptic actin cytoskeleton organization1IEAHomo_sapiens(9606)Process
GO:0120192involved_in tight junction assembly1IMPHomo_sapiens(9606)Process
GO:0120220located_in basal body patch1IEAHomo_sapiens(9606)Component
GO:0150111involved_in regulation of transepithelial transport1IMPHomo_sapiens(9606)Process
GO:1900242involved_in regulation of synaptic vesicle endocytosis1IEAHomo_sapiens(9606)Process
GO:1902396involved_in protein localization to bicellular tight junction1IMPHomo_sapiens(9606)Process

Expression