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RBP World!
Functions and Diseases
| RBP Type | Non-canonical_RBPs |
| Diseases | Disease |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | Kinase |
| Localizations | Stress granule or P-body |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000183735 | Gene ID | 29110 | Accession | 11584 |
| Symbol | TBK1 | Alias | NAK;T2K;IIAE8;FTDALS4 | Full Name | TANK binding kinase 1 |
| Status | Confidence | Length | 50025 bases | Strand | Plus strand |
| Position | 12 : 64452090 - 64502114 | RNA binding domain | N.A. | ||
| Summary | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| TBK1-229 | ENST00000676654 | 3204 | No protein | - |
| TBK1-242 | ENST00000677499 | 3108 | 575aa | ENSP00000502875 |
| TBK1-246 | ENST00000677641 | 3001 | 728aa | ENSP00000504637 |
| TBK1-230 | ENST00000676684 | 3629 | No protein | - |
| TBK1-220 | ENST00000652537 | 3092 | 575aa | ENSP00000499102 |
| TBK1-232 | ENST00000676809 | 3273 | 511aa | ENSP00000504298 |
| TBK1-212 | ENST00000650790 | 3006 | 729aa | ENSP00000498995 |
| TBK1-221 | ENST00000652657 | 2944 | 705aa | ENSP00000498887 |
| TBK1-234 | ENST00000676912 | 2956 | 677aa | ENSP00000503567 |
| TBK1-248 | ENST00000677686 | 5944 | No protein | - |
| TBK1-219 | ENST00000652389 | 2285 | 519aa | ENSP00000498414 |
| TBK1-243 | ENST00000677545 | 209 | 24aa | ENSP00000504729 |
| TBK1-260 | ENST00000678430 | 1261 | No protein | - |
| TBK1-226 | ENST00000676551 | 2331 | No protein | - |
| TBK1-213 | ENST00000650997 | 3178 | 731aa | ENSP00000498341 |
| TBK1-245 | ENST00000677632 | 2959 | 724aa | ENSP00000504586 |
| TBK1-215 | ENST00000651262 | 2902 | 551aa | ENSP00000498461 |
| TBK1-201 | ENST00000331710 | 3022 | 729aa | ENSP00000329967 |
| TBK1-256 | ENST00000678180 | 2869 | 695aa | ENSP00000504132 |
| TBK1-270 | ENST00000679065 | 1075 | No protein | - |
| TBK1-218 | ENST00000651947 | 1786 | No protein | - |
| TBK1-210 | ENST00000650762 | 2459 | 643aa | ENSP00000498758 |
| TBK1-235 | ENST00000676930 | 2649 | 613aa | ENSP00000502899 |
| TBK1-211 | ENST00000650786 | 3244 | 40aa | ENSP00000498280 |
| TBK1-251 | ENST00000677831 | 2960 | 541aa | ENSP00000503760 |
| TBK1-214 | ENST00000651014 | 3046 | 677aa | ENSP00000498885 |
| TBK1-244 | ENST00000677549 | 1987 | No protein | - |
| TBK1-203 | ENST00000538890 | 547 | 103aa | ENSP00000445834 |
| TBK1-216 | ENST00000651878 | 3151 | 240aa | ENSP00000499077 |
| TBK1-205 | ENST00000540417 | 513 | 98aa | ENSP00000445628 |
| TBK1-259 | ENST00000678368 | 484 | 29aa | ENSP00000504296 |
| TBK1-204 | ENST00000539810 | 419 | 48aa | ENSP00000444428 |
| TBK1-222 | ENST00000676469 | 248 | 72aa | ENSP00000503155 |
| TBK1-257 | ENST00000678197 | 2906 | No protein | - |
| TBK1-269 | ENST00000679050 | 502 | 50aa | ENSP00000503595 |
| TBK1-209 | ENST00000650708 | 2751 | 542aa | ENSP00000498667 |
| TBK1-233 | ENST00000676901 | 232 | No protein | - |
| TBK1-254 | ENST00000678079 | 234 | 78aa | ENSP00000503613 |
| TBK1-250 | ENST00000677759 | 558 | 86aa | ENSP00000503847 |
| TBK1-271 | ENST00000679302 | 469 | 45aa | ENSP00000503553 |
| TBK1-217 | ENST00000651889 | 1573 | No protein | - |
| TBK1-265 | ENST00000678808 | 443 | 64aa | ENSP00000503260 |
| TBK1-238 | ENST00000677112 | 595 | 63aa | ENSP00000504208 |
| TBK1-264 | ENST00000678738 | 875 | 86aa | ENSP00000503263 |
| TBK1-237 | ENST00000677016 | 757 | 86aa | ENSP00000504578 |
| TBK1-253 | ENST00000677973 | 473 | 62aa | ENSP00000503248 |
| TBK1-239 | ENST00000677242 | 191 | No protein | - |
| TBK1-263 | ENST00000678718 | 478 | 79aa | ENSP00000504038 |
| TBK1-236 | ENST00000676983 | 308 | 103aa | ENSP00000503561 |
| TBK1-247 | ENST00000677670 | 145 | No protein | - |
| TBK1-258 | ENST00000678235 | 210 | No protein | - |
| TBK1-207 | ENST00000545025 | 371 | 44aa | ENSP00000504046 |
| TBK1-252 | ENST00000677858 | 312 | 47aa | ENSP00000502994 |
| TBK1-223 | ENST00000676490 | 438 | 77aa | ENSP00000503569 |
| TBK1-202 | ENST00000536906 | 756 | No protein | - |
| TBK1-225 | ENST00000676539 | 300 | 40aa | ENSP00000504315 |
| TBK1-231 | ENST00000676774 | 1160 | No protein | - |
| TBK1-262 | ENST00000678582 | 357 | 36aa | ENSP00000504002 |
| TBK1-268 | ENST00000679010 | 957 | No protein | - |
| TBK1-241 | ENST00000677435 | 301 | 42aa | ENSP00000504836 |
| TBK1-261 | ENST00000678567 | 509 | 90aa | ENSP00000504755 |
| TBK1-227 | ENST00000676587 | 864 | 40aa | ENSP00000504858 |
| TBK1-249 | ENST00000677714 | 60 | No protein | - |
| TBK1-206 | ENST00000541805 | 1380 | No protein | - |
| TBK1-208 | ENST00000545392 | 1781 | No protein | - |
| TBK1-267 | ENST00000678996 | 238 | 41aa | ENSP00000503169 |
| TBK1-224 | ENST00000676521 | 433 | 64aa | ENSP00000503000 |
| TBK1-255 | ENST00000678125 | 111 | 37aa | ENSP00000504253 |
| TBK1-228 | ENST00000676593 | 877 | 43aa | ENSP00000503458 |
| TBK1-240 | ENST00000677313 | 1008 | 30aa | ENSP00000503363 |
| TBK1-266 | ENST00000678992 | 756 | No protein | - |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0002218 | involved_in activation of innate immune response | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0002753 | involved_in cytosolic pattern recognition receptor signaling pathway | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0003676 | enables nucleic acid binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0004672 | enables protein kinase activity | 1 | NAS | Homo_sapiens(9606) | Function |
| GO:0004674 | enables protein serine/threonine kinase activity | 4 | EXP,IBA,IDA,TAS | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005524 | enables ATP binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0005654 | located_in nucleoplasm | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005737 | is_active_in cytoplasm | 3 | IBA,IDA | Homo_sapiens(9606) | Component |
| GO:0005829 | is_active_in cytosol | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0006468 | involved_in protein phosphorylation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0006954 | involved_in inflammatory response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0007249 | involved_in I-kappaB kinase/NF-kappaB signaling | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0009615 | involved_in response to virus | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0010508 | involved_in positive regulation of autophagy | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0010629 | involved_in negative regulation of gene expression | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0010803 | involved_in regulation of tumor necrosis factor-mediated signaling pathway | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0016239 | involved_in positive regulation of macroautophagy | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0018105 | involved_in peptidyl-serine phosphorylation | 2 | IBA,IDA | Homo_sapiens(9606) | Process |
| GO:0018107 | involved_in peptidyl-threonine phosphorylation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0019903 | enables protein phosphatase binding | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0032479 | involved_in regulation of type I interferon production | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0032481 | involved_in positive regulation of type I interferon production | 2 | IDA,TAS | Homo_sapiens(9606) | Process |
| GO:0032727 | involved_in positive regulation of interferon-alpha production | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0032728 | involved_in positive regulation of interferon-beta production | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0033138 | involved_in positive regulation of peptidyl-serine phosphorylation | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0042802 | enables identical protein binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0043123 | involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling | 1 | IEP | Homo_sapiens(9606) | Process |
| GO:0043231 | located_in intracellular membrane-bounded organelle | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0044565 | involved_in dendritic cell proliferation | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0045087 | involved_in innate immune response | 2 | IDA,TAS | Homo_sapiens(9606) | Process |
| GO:0045944 | involved_in positive regulation of transcription by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0050830 | involved_in defense response to Gram-positive bacterium | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0051219 | enables phosphoprotein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0051607 | involved_in defense response to virus | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0060337 | involved_in type I interferon-mediated signaling pathway | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0060340 | involved_in positive regulation of type I interferon-mediated signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0106310 | enables protein serine kinase activity | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0140374 | involved_in antiviral innate immune response | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:1901214 | involved_in regulation of neuron death | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:1902554 | part_of serine/threonine protein kinase complex | 1 | NAS | Homo_sapiens(9606) | Component |
| GO:1904417 | involved_in positive regulation of xenophagy | 1 | IEA | Homo_sapiens(9606) | Process |