Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000182463 Gene ID 128553 Accession 13010
Symbol TSHZ2 Alias TSH2;ZABC2;ZNF218;OVC10-2;C20orf17 Full Name teashirt zinc finger homeobox 2
Status Confidence Length 522973 bases Strand Plus strand
Position 20 : 52972358 - 53495330 RNA binding domain zf-met
Summary This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000474159 zf-met PF12874 0.0011 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34561612 Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain. Gwangho Yoon 2021-11-01 Molecular psychiatry

Transcripts

Name Transcript ID bp Protein Translation ID
TSHZ2-201 ENST00000371497 12236 1034aa ENSP00000360552
TSHZ2-202 ENST00000603338 3803 1031aa ENSP00000475114
TSHZ2-203 ENST00000605656 980 194aa ENSP00000474159
TSHZ2-204 ENST00000626626 670 74aa ENSP00000487408

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
4076Triglycerides5.42009795376943E-717903299
4079Triglycerides5.42009795376943E-717903299
8349Heart Rate2.03554486063229E-617903306
8351Heart Rate2.87998112687892E-617903306
8421Alcohol Drinking2.76505996483802E-5-
13836Myocardial Infarction8.0765937E-004-
14344Iron9.7440000E-00419880490
22940Body Height8.0900000E-005-
23126Body Height9.9090000E-005-
23174Body Height6.3420000E-005-
29426Cholesterol, LDL4.3710000E-006-
29436Cholesterol, LDL3.0590000E-006-
30078Cholesterol9.1890000E-007-
30085Cholesterol9.3210000E-007-
30654Erythrocyte Count2.2200000E-005-
30655Erythrocyte Count4.5350000E-005-
36410Platelet Function Tests2.6656500E-005-
36417Platelet Function Tests4.1700000E-006-
37333Platelet Function Tests1.2979900E-005-
37365Platelet Function Tests1.2979900E-005-
37426Platelet Function Tests9.7000000E-006-
38954Platelet Function Tests1.6820300E-005-
38955Platelet Function Tests2.9461200E-005-
40509Platelet Function Tests1.0944900E-005-
40511Platelet Function Tests5.9600000E-006-
42966Platelet Function Tests1.3515300E-005-
45909Platelet Function Tests2.8887300E-005-
50801Child Development Disorders, Pervasive2.0189000E-005-
54707Erythropoietin6.8690000E-005-
83642Bipolar Disorder3E-624322204
83643Body Mass Index3E-624322204
99582Anticoagulants9E-626265036
101067Coronary Aneurysm7E-627171184
101068Mucocutaneous Lymph Node Syndrome7E-627171184

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific2IBA,ISAHomo_sapiens(9606)Function
GO:0003677enables DNA binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function

Expression