RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	ncRNA
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000182134	Gene ID	11022	Accession	11713
Symbol	TDRKH	Alias	TDRD2	Full Name	tudor and KH domain containing
Status	Confidence	Length	21310 bases	Strand	Minus strand
Position	1 : 151770107 - 151791416	RNA binding domain	KH_1 , TUDOR
Summary	Predicted to enable RNA binding activity. Predicted to be involved in fertilization; gamete generation; and piRNA metabolic process. Predicted to be located in mitochondrion; pi-body; and piP-body. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000357812	TUDOR	PF00567	7.2e-30	1
ENSP00000357812	KH_1	PF00013	8.6e-33	2
ENSP00000357812	KH_1	PF00013	8.6e-33	3
ENSP00000357813	TUDOR	PF00567	7.1e-30	1
ENSP00000357813	KH_1	PF00013	4.6e-27	2
ENSP00000357813	KH_1	PF00013	4.6e-27	3
ENSP00000357815	TUDOR	PF00567	7.2e-30	1
ENSP00000357815	KH_1	PF00013	8.6e-33	2
ENSP00000357815	KH_1	PF00013	8.6e-33	3
ENSP00000357817	TUDOR	PF00567	5.8e-30	1
ENSP00000357817	KH_1	PF00013	1.3e-18	2
ENSP00000357819	TUDOR	PF00567	7.2e-30	1
ENSP00000357819	KH_1	PF00013	8.6e-33	2
ENSP00000357819	KH_1	PF00013	8.6e-33	3
ENSP00000395718	TUDOR	PF00567	7.2e-30	1
ENSP00000395718	KH_1	PF00013	8.6e-33	2
ENSP00000395718	KH_1	PF00013	8.6e-33	3
ENSP00000431557	KH_1	PF00013	2e-16	1
ENSP00000433678	KH_1	PF00013	3.3e-14	1
ENSP00000437147	KH_1	PF00013	3.3e-14	1

Showing 1 to 20 of 20 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
33735607	ChIRP.MS_PMID33735607_human		Bingfei Yu	2021 Apr 1	doi: 10.1016/j.cell.2021.02.015.?Epub 2021 Mar 17
34077720	RIC_PMID34077720_RIC_hESCs_human	hESC	Shlomi Dvir	2021 Jun 1	doi: 10.1016/j.celrep.2021.109198
35451177	PhotoCAX.MS_PMID35451177_293T_human	293T	Huixin Luo	2022 Jul 4	doi: 10.1002/anie.202202008
37421941	RIC_PMID37421941_Hydra10_human		Wenhao Jin	2023 Jul 20	doi: 10.1016/j.molcel.2023.06.019.?Epub 2023 Jul 7

Showing 1 to 5 of 5 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
10767542	Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains.	S F Lamb	2000-04-04	Gene
37488572	Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.	Qian Chen	2023-07-24	Journal of translational medicine

Showing 1 to 2 of 2 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
TDRKH-201	ENST00000368822	3093	561aa	ENSP00000357812
TDRKH-202	ENST00000368823	2751	557aa	ENSP00000357813
TDRKH-203	ENST00000368824	2792	561aa	ENSP00000357815
TDRKH-204	ENST00000368825	2651	516aa	ENSP00000357817
TDRKH-205	ENST00000368827	2318	561aa	ENSP00000357819
TDRKH-206	ENST00000458431	2768	561aa	ENSP00000395718
TDRKH-207	ENST00000463553	371	No protein	-
TDRKH-208	ENST00000484421	862	No protein	-
TDRKH-209	ENST00000486986	760	No protein	-
TDRKH-210	ENST00000494725	548	No protein	-

Showing 1 to 10 of 14 entries

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Gene Model

Click here to download ENSG00000182134's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
4007	Triglycerides	1.23020318463272E-21	17903299
4250	Lipids	1.77177900746748E-6	17903299
6111	Hemoglobins	3.87474530679068E-13	17903294
6125	Hemoglobins	9.82361694088194E-8	17903294

Showing 1 to 4 of 4 entries

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000182134	rs4845570	1	151786628	Coronary artery disease	29212778	0.058	EFO_0000378
ENSG00000182134	rs11810571	1	151789832	Coronary artery disease	29212778	0.0553	EFO_0000378

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000182134's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000182134	homo_sapiens	ENSP00000384376	9.97932	5.63599	homo_sapiens	ENSP00000357815	34.4029	19.4296
ENSG00000182134	homo_sapiens	ENSP00000406052	16.1353	8.69565	homo_sapiens	ENSP00000357815	29.7683	16.0428
ENSG00000182134	homo_sapiens	ENSP00000357467	23.6467	12.8205	homo_sapiens	ENSP00000357815	14.795	8.02139
ENSG00000182134	homo_sapiens	ENSP00000346065	8.87405	4.8187	homo_sapiens	ENSP00000357815	33.1551	18.0036
ENSG00000182134	homo_sapiens	ENSP00000347444	14.8452	7.9235	homo_sapiens	ENSP00000357815	29.0553	15.508
ENSG00000182134	homo_sapiens	ENSP00000511878	13.0508	6.77966	homo_sapiens	ENSP00000357815	27.451	14.2602

Showing 1 to 6 of 6 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000182134	homo_sapiens	ENSP00000357815	97.6827	96.2567	nomascus_leucogenys	ENSNLEP00000012547	91.9463	90.604
ENSG00000182134	homo_sapiens	ENSP00000357815	97.861	96.9697	pan_paniscus	ENSPPAP00000011585	90.7438	89.9174
ENSG00000182134	homo_sapiens	ENSP00000357815	99.6435	99.287	pongo_abelii	ENSPPYP00000000998	99.6435	99.287
ENSG00000182134	homo_sapiens	ENSP00000357815	97.861	96.9697	pan_troglodytes	ENSPTRP00000064856	90.7438	89.9174
ENSG00000182134	homo_sapiens	ENSP00000357815	98.0392	96.9697	gorilla_gorilla	ENSGGOP00000045375	90.9091	89.9174
ENSG00000182134	homo_sapiens	ENSP00000357815	75.4011	61.4973	ornithorhynchus_anatinus	ENSOANP00000047031	69.9174	57.0248
ENSG00000182134	homo_sapiens	ENSP00000357815	90.5526	83.6007	sarcophilus_harrisii	ENSSHAP00000026133	83.8284	77.3927
ENSG00000182134	homo_sapiens	ENSP00000357815	79.6791	72.3708	notamacropus_eugenii	ENSMEUP00000005611	78.836	71.6049
ENSG00000182134	homo_sapiens	ENSP00000357815	78.4314	74.5098	choloepus_hoffmanni	ENSCHOP00000000230	81.6327	77.551
ENSG00000182134	homo_sapiens	ENSP00000357815	85.0267	80.9269	dasypus_novemcinctus	ENSDNOP00000028636	92.6214	88.1553

Showing 1 to 10 of 136 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0007283	involved_in spermatogenesis	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0034587	involved_in piRNA processing	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005739	located_in mitochondrion	1	ISS	Homo_sapiens(9606)	Component
GO:0007140	involved_in male meiotic nuclear division	1	ISS	Homo_sapiens(9606)	Process
GO:0009566	involved_in fertilization	1	ISS	Homo_sapiens(9606)	Process
GO:0030719	involved_in P granule organization	1	IBA	Homo_sapiens(9606)	Process
GO:0043186	is_active_in P granule	1	IBA	Homo_sapiens(9606)	Component
GO:0071546	located_in pi-body	1	ISS	Homo_sapiens(9606)	Component

Showing 1 to 10 of 11 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression