RBP Type	Non-canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000181019	Gene ID	1728	Accession	2874
Symbol	NQO1	Alias	DTD;QR1;DHQU;DIA4;NMOR1;NMORI	Full Name	NAD(P)H quinone dehydrogenase 1
Status	Confidence	Length	19673 bases	Strand	Minus strand
Position	16 : 69706996 - 69726668	RNA binding domain	N.A.
Summary	This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]