RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligaseTF
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000179456	Gene ID	10472	Accession	13030
Symbol	ZBTB18	Alias	RP58;MRD22;TAZ-1;ZNF238;C2H2-171;DEL1Q42Q44;DEL1Q43Q44;C1DELq42q44;C1DELq43q44	Full Name	zinc finger and BTB domain containing 18
Status	Confidence	Length	8930 bases	Strand	Plus strand
Position	1 : 244048547 - 244057476	RNA binding domain	N.A.
Summary	This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
ZBTB18-203	ENST00000696615	1642	227aa	ENSP00000512755
ZBTB18-202	ENST00000622512	3740	522aa	ENSP00000481278
ZBTB18-204	ENST00000696616	3808	522aa	ENSP00000512756
ZBTB18-201	ENST00000358704	3851	531aa	ENSP00000351539
ZBTB18-205	ENST00000696617	3952	56aa	ENSP00000512757
ZBTB18-207	ENST00000698634	547	139aa	ENSP00000513849
ZBTB18-206	ENST00000696618	3731	522aa	ENSP00000512758

Gene Model

Click here to download ENSG00000179456's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
14197	Iron	5.0830000E-004	19880490
22003	Personality	5.639e-005	-
22007	Personality	3.556e-005	-
22015	Personality	3.556e-005	-
29399	Cholesterol, LDL	2.3110000E-005	-
29579	Cholesterol	4.4120000E-005	-
45163	Platelet Function Tests	7.6313960E-006	-
86445	Asthma	6E-6	22560479
102467	Schizophrenia	1E-6	22885689
103173	Ovarian Neoplasms	4E-6	25134534

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000179456's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0000792	part_of heterochromatin	1	IDA	Homo_sapiens(9606)	Component
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	1	IBA	Homo_sapiens(9606)	Function
GO:0001227	enables DNA-binding transcription repressor activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0003677	enables DNA binding	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0007519	involved_in skeletal muscle tissue development	1	ISS	Homo_sapiens(9606)	Process
GO:0016607	located_in nuclear speck	1	IDA	Homo_sapiens(9606)	Component
GO:0043565	enables sequence-specific DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	ISS	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:1990837	enables sequence-specific double-stranded DNA binding	1	IDA	Homo_sapiens(9606)	Function

Expression