RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000178700	Gene ID	200895	Accession	27309
Symbol	DHFR2	Alias	DHFRL1;DHFRP4	Full Name	dihydrofolate reductase 2
Status	Confidence	Length	5468 bases	Strand	Minus strand
Position	3 : 94057922 - 94063389	RNA binding domain	N.A.
Summary	Enables dihydrofolate reductase activity and mRNA binding activity. Involved in tetrahydrofolate metabolic process and thymidine biosynthetic process. Located in mitochondrial inner membrane and mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
DHFR2-204	ENST00000481631	632	No protein	-
DHFR2-201	ENST00000314636	3856	187aa	ENSP00000319170
DHFR2-202	ENST00000394221	3733	187aa	ENSP00000377768
DHFR2-203	ENST00000461173	1831	187aa	ENSP00000418415
DHFR2-206	ENST00000619045	1802	187aa	ENSP00000480823
DHFR2-205	ENST00000496983	591	114aa	ENSP00000420810

Gene Model

Click here to download ENSG00000178700's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000178700's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003729	enables mRNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004146	enables dihydrofolate reductase activity	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0005739	is_active_in mitochondrion	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005743	located_in mitochondrial inner membrane	1	IMP	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	IMP	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006545	involved_in glycine biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006730	involved_in one-carbon metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0033560	enables folate reductase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0046105	involved_in thymidine biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046452	involved_in dihydrofolate metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0046653	involved_in tetrahydrofolate metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046654	involved_in tetrahydrofolate biosynthetic process	2	IBA,IEA	Homo_sapiens(9606)	Process
GO:0046655	involved_in folic acid metabolic process	2	IBA,TAS	Homo_sapiens(9606)	Process
GO:0050661	enables NADP binding	1	IBA	Homo_sapiens(9606)	Function

Expression