Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2Dengue
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000177889 Gene ID 7334 Accession 12492
Symbol UBE2N Alias UBC13;UbcH13;UBCHBEN;HEL-S-71;UbcH-ben;UBCHBEN;UBC13 Full Name ubiquitin conjugating enzyme E2 N
Status Confidence Length 36264 bases Strand Minus strand
Position 12 : 93405684 - 93441947 RNA binding domain N.A.
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
UBE2N-202 ENST00000548946 492 No protein -
UBE2N-201 ENST00000318066 4877 152aa ENSP00000316176
UBE2N-205 ENST00000550657 3018 152aa ENSP00000449352
UBE2N-204 ENST00000549833 960 89aa ENSP00000450260
UBE2N-203 ENST00000549490 676 87aa ENSP00000447009
UBE2N-206 ENST00000552442 607 105aa ENSP00000448352

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
28188Insulin Resistance8.4890000E-005-
35489Platelet Function Tests2.4900000E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000151part_of ubiquitin ligase complex1IDAHomo_sapiens(9606)Component
GO:0000724involved_in double-strand break repair via homologous recombination1IMPHomo_sapiens(9606)Process
GO:0000729involved_in DNA double-strand break processing1IMPHomo_sapiens(9606)Process
GO:0001650located_in fibrillar center1IDAHomo_sapiens(9606)Component
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IC,IDA,TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006282involved_in regulation of DNA repair1TASHomo_sapiens(9606)Process
GO:0006301involved_in postreplication repair2IBA,IMPHomo_sapiens(9606)Process
GO:0006511involved_in ubiquitin-dependent protein catabolic process1IEAHomo_sapiens(9606)Process
GO:0016567involved_in protein ubiquitination2IMP,TASHomo_sapiens(9606)Process
GO:0016574involved_in histone ubiquitination1IMPHomo_sapiens(9606)Process
GO:0031372part_of UBC13-MMS2 complex2IDA,IPIHomo_sapiens(9606)Component
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0033182involved_in regulation of histone ubiquitination1IMPHomo_sapiens(9606)Process
GO:0035370part_of UBC13-UEV1A complex2IDA,IPIHomo_sapiens(9606)Component
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IMPHomo_sapiens(9606)Process
GO:0043130enables ubiquitin binding1IDAHomo_sapiens(9606)Function
GO:0045739involved_in positive regulation of DNA repair1IMPHomo_sapiens(9606)Process
GO:0050852involved_in T cell receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IMPHomo_sapiens(9606)Process
GO:0051443involved_in positive regulation of ubiquitin-protein transferase activity1IMPHomo_sapiens(9606)Process
GO:0061631enables ubiquitin conjugating enzyme activity3IBA,ISS,TASHomo_sapiens(9606)Function
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070534involved_in protein K63-linked ubiquitination3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0140374involved_in antiviral innate immune response1IDAHomo_sapiens(9606)Process
GO:1902523involved_in positive regulation of protein K63-linked ubiquitination1IDAHomo_sapiens(9606)Process
GO:1902533involved_in positive regulation of intracellular signal transduction1IDAHomo_sapiens(9606)Process
GO:2000781involved_in positive regulation of double-strand break repair1IDAHomo_sapiens(9606)Process

Expression