Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000177606 Gene ID 3725 Accession 6204
Symbol JUN Alias AP1;p39;AP-1;cJUN;c-Jun Full Name Jun proto-oncogene, AP-1 transcription factor subunit
Status Confidence Length 7204 bases Strand Minus strand
Position 1 : 58776845 - 58784048 RNA binding domain N.A.
Summary This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27473170 RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA. Giorgia G Del 2016-10-01 RNA (New York, N.Y.)
36165706 A novel long non-coding RNA, lnc-RNU12, influences the T-cell cycle via c-JUN and CCNL2 in rheumatoid arthritis. Xing-Bo Mo 2023-05-02 Rheumatology (Oxford, England)

Transcripts

Name Transcript ID bp Protein Translation ID
JUN-202 ENST00000678696 2852 331aa ENSP00000503132
JUN-201 ENST00000371222 3257 331aa ENSP00000360266
JUN-203 ENST00000710273 3257 353aa ENSP00000518166

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0000228located_in nuclear chromosome1TASHomo_sapiens(9606)Component
GO:0000785part_of chromatin2IDA,ISAHomo_sapiens(9606)Component
GO:0000791part_of euchromatin1IDAHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding1IDAHomo_sapiens(9606)Function
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific4IBA,IC,IDA,ISAHomo_sapiens(9606)Function
GO:0001227enables DNA-binding transcription repressor activity, RNA polymerase II-specific1IDAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific2IDA,IMPHomo_sapiens(9606)Function
GO:0003677enables DNA binding1TASHomo_sapiens(9606)Function
GO:0003700enables DNA-binding transcription factor activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005096enables GTPase activator activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005667part_of transcription regulator complex1IBAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II3IBA,IDA,NASHomo_sapiens(9606)Process
GO:0007179involved_in transforming growth factor beta receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0008134enables transcription factor binding1IBAHomo_sapiens(9606)Function
GO:0019046involved_in release from viral latency1IDAHomo_sapiens(9606)Process
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0034614involved_in cellular response to reactive oxygen species1IMPHomo_sapiens(9606)Process
GO:0035497enables cAMP response element binding1IDAHomo_sapiens(9606)Function
GO:0035976part_of transcription factor AP-1 complex3IDA,IMP,IPIHomo_sapiens(9606)Component
GO:0042127involved_in regulation of cell population proliferation1IBAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043065involved_in positive regulation of apoptotic process1IMPHomo_sapiens(9606)Process
GO:0043392involved_in negative regulation of DNA binding1IDAHomo_sapiens(9606)Process
GO:0043922involved_in negative regulation by host of viral transcription1IDAHomo_sapiens(9606)Process
GO:0043923involved_in positive regulation by host of viral transcription1IDAHomo_sapiens(9606)Process
GO:0044389enables ubiquitin-like protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0045892involved_in negative regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription2IDA,IMPHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II2IDA,NASHomo_sapiens(9606)Process
GO:0051726involved_in regulation of cell cycle1IBAHomo_sapiens(9606)Process
GO:0060395involved_in SMAD protein signal transduction1IDAHomo_sapiens(9606)Process
GO:0061629enables RNA polymerase II-specific DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:0070412enables R-SMAD binding1IPIHomo_sapiens(9606)Function
GO:0071276involved_in cellular response to cadmium ion1IMPHomo_sapiens(9606)Process
GO:0090575part_of RNA polymerase II transcription regulator complex1IPIHomo_sapiens(9606)Component
GO:0140296enables general transcription initiation factor binding1IPIHomo_sapiens(9606)Function
GO:0140467involved_in integrated stress response signaling1NASHomo_sapiens(9606)Process
GO:1902895involved_in positive regulation of miRNA transcription2IMP,ISSHomo_sapiens(9606)Process
GO:1904707involved_in positive regulation of vascular associated smooth muscle cell proliferation1IMPHomo_sapiens(9606)Process
GO:1990441involved_in negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1IMPHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:2000144involved_in positive regulation of DNA-templated transcription initiation1IDAHomo_sapiens(9606)Process

Expression