RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000177238	Gene ID	493829	Accession	32671
Symbol	TRIM72	Alias	MG53	Full Name	tripartite motif containing 72
Status	Confidence	Length	17447 bases	Strand	Plus strand
Position	16 : 31214091 - 31231537	RNA binding domain	SPRY
Summary	Enables identical protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; plasma membrane repair; and protein homooligomerization. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; and negative regulation of myotube differentiation. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in cytoplasm and sarcolemma. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000312675	SPRY	PF00622	6.9e-08	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
TRIM72-201	ENST00000322122	8402	477aa	ENSP00000312675

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001778	involved_in plasma membrane repair	1	ISS	Homo_sapiens(9606)	Process
GO:0001786	enables phosphatidylserine binding	1	ISS	Homo_sapiens(9606)	Function
GO:0003012	involved_in muscle system process	1	ISS	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0006887	involved_in exocytosis	1	IEA	Homo_sapiens(9606)	Process
GO:0007517	involved_in muscle organ development	1	ISS	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0010832	involved_in negative regulation of myotube differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IBA	Homo_sapiens(9606)	Process
GO:0030659	located_in cytoplasmic vesicle membrane	2	ISS,TAS	Homo_sapiens(9606)	Component
GO:0031435	enables mitogen-activated protein kinase kinase kinase binding	1	IEA	Homo_sapiens(9606)	Function
GO:0031624	enables ubiquitin conjugating enzyme binding	1	IEA	Homo_sapiens(9606)	Function
GO:0042383	is_active_in sarcolemma	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0043569	involved_in negative regulation of insulin-like growth factor receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0046627	involved_in negative regulation of insulin receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0051260	involved_in protein homooligomerization	1	ISS	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	1	IBA	Homo_sapiens(9606)	Function