Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000177169 Gene ID 8408 Accession 12558
Symbol ULK1 Alias ATG1;ATG1A;UNC51;hATG1;Unc51.1 Full Name unc-51 like autophagy activating kinase 1
Status Confidence Length 28529 bases Strand Plus strand
Position 12 : 131894622 - 131923150 RNA binding domain RIO1
Summary Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000324560 RIO1 PF01163 0.00031 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36642732 Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1. Ruifan Wu 2023-01-16 Cell death & disease

Transcripts

Name Transcript ID bp Protein Translation ID
ULK1-201 ENST00000321867 5322 1050aa ENSP00000324560
ULK1-202 ENST00000537421 959 No protein -
ULK1-206 ENST00000542313 307 No protein -
ULK1-205 ENST00000541761 1262 No protein -
ULK1-204 ENST00000540647 1211 No protein -
ULK1-207 ENST00000544718 1678 No protein -
ULK1-203 ENST00000540568 2145 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000045involved_in autophagosome assembly2IBA,IDAHomo_sapiens(9606)Process
GO:0000407is_active_in phagophore assembly site2IBA,IDAHomo_sapiens(9606)Component
GO:0000421located_in autophagosome membrane1IDAHomo_sapiens(9606)Component
GO:0000422involved_in autophagy of mitochondrion1IBAHomo_sapiens(9606)Process
GO:0004674enables protein serine/threonine kinase activity5EXP,IBA,IDA,NAS,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm4IBA,IC,IDA,NASHomo_sapiens(9606)Component
GO:0005741located_in mitochondrial outer membrane1TASHomo_sapiens(9606)Component
GO:0005776is_active_in autophagosome2IBA,IDAHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0006468involved_in protein phosphorylation2IDA,NASHomo_sapiens(9606)Process
GO:0006914involved_in autophagy4IDA,IGI,IMP,ISSHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1IEAHomo_sapiens(9606)Process
GO:0008104involved_in protein localization1IMPHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IDAHomo_sapiens(9606)Process
GO:0010508involved_in positive regulation of autophagy4IBA,IDA,ISO,ISSHomo_sapiens(9606)Process
GO:0010803involved_in regulation of tumor necrosis factor-mediated signaling pathway1TASHomo_sapiens(9606)Process
GO:0016236involved_in macroautophagy2IMP,TASHomo_sapiens(9606)Process
GO:0016241involved_in regulation of macroautophagy1IDAHomo_sapiens(9606)Process
GO:0018105involved_in peptidyl-serine phosphorylation2IBA,IDAHomo_sapiens(9606)Process
GO:0018107involved_in peptidyl-threonine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0030424located_in axon1IEAHomo_sapiens(9606)Component
GO:0031102involved_in neuron projection regeneration1IEAHomo_sapiens(9606)Process
GO:0031175involved_in neuron projection development1IMPHomo_sapiens(9606)Process
GO:0031267enables small GTPase binding1IPIHomo_sapiens(9606)Function
GO:0031333involved_in negative regulation of protein-containing complex assembly1IDAHomo_sapiens(9606)Process
GO:0031669involved_in cellular response to nutrient levels1ISSHomo_sapiens(9606)Process
GO:0034045is_active_in phagophore assembly site membrane2IBA,IDAHomo_sapiens(9606)Component
GO:0034727involved_in piecemeal microautophagy of the nucleus1IBAHomo_sapiens(9606)Process
GO:0042594involved_in response to starvation2IBA,ISSHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0044805involved_in late nucleophagy1IBAHomo_sapiens(9606)Process
GO:0044877enables protein-containing complex binding1IPIHomo_sapiens(9606)Function
GO:0046777involved_in protein autophosphorylation2IBA,IDAHomo_sapiens(9606)Process
GO:0048671involved_in negative regulation of collateral sprouting1IBAHomo_sapiens(9606)Process
GO:0048675involved_in axon extension1IBAHomo_sapiens(9606)Process
GO:0051020enables GTPase binding1IPIHomo_sapiens(9606)Function
GO:0055037located_in recycling endosome1TASHomo_sapiens(9606)Component
GO:0061709involved_in reticulophagy1IBAHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1903059involved_in regulation of protein lipidation1IDAHomo_sapiens(9606)Process
GO:1903349located_in omegasome membrane1IDAHomo_sapiens(9606)Component
GO:1990316part_of Atg1/ULK1 kinase complex1IPIHomo_sapiens(9606)Component
GO:2000786involved_in positive regulation of autophagosome assembly1IEAHomo_sapiens(9606)Process

Expression