Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Nucleoli
BulkPerturb-seq

Description

Ensembl ID ENSG00000176979 Gene ID 166655 Accession 21162
Symbol TRIM60 Alias RNF33;RNF129 Full Name tripartite motif containing 60
Status Confidence Length 25292 bases Strand Plus strand
Position 4 : 165016458 - 165041749 RNA binding domain SPRY
Summary The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000343765 SPRY PF00622 1.4e-09 1
ENSP00000421142 SPRY PF00622 1.4e-09 1
ENSP00000426496 SPRY PF00622 1.4e-09 1
ENSP00000497401 SPRY PF00622 1.4e-09 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
TRIM60-205 ENST00000647760 2702 471aa ENSP00000497401
TRIM60-204 ENST00000512596 1847 471aa ENSP00000421142
TRIM60-202 ENST00000507119 389 90aa ENSP00000421784
TRIM60-203 ENST00000508504 1674 471aa ENSP00000426496
TRIM60-201 ENST00000341062 1867 471aa ENSP00000343765

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm2IBA,ICHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol1IBAHomo_sapiens(9606)Component
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0016567involved_in protein ubiquitination1IBAHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity1IBAHomo_sapiens(9606)Function
GO:0140082enables SUMO-ubiquitin ligase activity1IDAHomo_sapiens(9606)Function
GO:1901223involved_in negative regulation of NIK/NF-kappaB signaling1IDAHomo_sapiens(9606)Process

Expression