Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000176890 Gene ID 7298 Accession 12441
Symbol TYMS Alias TS;TMS;DKCD;HST422 Full Name thymidylate synthetase
Status Confidence Length 15926 bases Strand Plus strand
Position 18 : 657653 - 673578 RNA binding domain N.A.
Summary Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
22887475 Thymidylate synthase polymorphisms and risk of conotruncal heart defects. Huiping Zhu 2012-09-01 American journal of medical genetics. Part A
29216518 Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer. Samantha Moore 2018-02-01 Current opinion in genetics & development
34858842 Identification and Validation of TYMS as a Potential Biomarker for Risk of Metastasis Development in Hepatocellular Carcinoma. Shuai Li 2021-01-01 Frontiers in oncology
27057637 Cancer drug resistance: redox resetting renders a way. Yuan Liu 2016-07-05 Oncotarget
19190136 Association of thymidylate synthase gene with endometrial cancer risk in a Chinese population. Wang-Hong Xu 2009-02-01 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
28207544 TSER polymorphism is not associated with risk of pediatric acute lymphoblastic leukemia: A meta-analysis. Zhaohua Qiao 2017-02-01 Medicine
22496803 Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: a tool for pharmacogenetic studies. Soma Ghosh 2012-01-01 PloS one
34694685 Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex. Sharon Spizzichino 2022-03-01 The FEBS journal
36380143 Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy. C Laurence Cheung 2023-01-01 Leukemia
32708710 Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins. Eva Aubets 2020-07-16 International journal of molecular sciences
29735940 New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide. Dan Xie 2018-05-07 International journal of molecular sciences

Transcripts

Name Transcript ID bp Protein Translation ID
TYMS-203 ENST00000323274 1613 313aa ENSP00000315644
TYMS-204 ENST00000579128 925 No protein -
TYMS-202 ENST00000323250 693 230aa ENSP00000314902
TYMS-201 ENST00000323224 1327 279aa ENSP00000314727
TYMS-206 ENST00000584122 534 No protein -
TYMS-205 ENST00000581920 886 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000176890homo_sapiensENSP0000039630836.898422.9947homo_sapiensENSP0000031564422.044713.738
ENSG00000176890homo_sapiensENSP0000031917035.294121.3904homo_sapiensENSP0000031564421.086312.7796

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000176890homo_sapiensENSP0000031564454.632653.0351nomascus_leucogenysENSNLEP0000000834098.843995.9538
ENSG00000176890homo_sapiensENSP0000031564410099.0415pan_paniscusENSPPAP0000002735910099.0415
ENSG00000176890homo_sapiensENSP0000031564499.680598.722pongo_abeliiENSPPYP0000001015599.680598.722
ENSG00000176890homo_sapiensENSP0000031564410099.0415pan_troglodytesENSPTRP0000001671610099.0415
ENSG00000176890homo_sapiensENSP0000031564485.62384.984gorilla_gorillaENSGGOP0000002516696.057495.3405
ENSG00000176890homo_sapiensENSP0000031564492.971284.345ornithorhynchus_anatinusENSOANP0000003839193.269284.6154
ENSG00000176890homo_sapiensENSP0000031564450.798747.6038sarcophilus_harrisiiENSSHAP0000000353296.363690.303
ENSG00000176890homo_sapiensENSP0000031564474.760469.968notamacropus_eugeniiENSMEUP0000000867573.12568.4375
ENSG00000176890homo_sapiensENSP0000031564493.610290.4153dasypus_novemcinctusENSDNOP0000001817790.993887.8882
ENSG00000176890homo_sapiensENSP0000031564461.661357.8275erinaceus_europaeusENSEEUP0000000824287.727382.2727
ENSG00000176890homo_sapiensENSP0000031564498.402695.8466callithrix_jacchusENSCJAP0000000023298.402695.8466
ENSG00000176890homo_sapiensENSP0000031564490.734888.1789cercocebus_atysENSCATP0000001188292.207889.6104
ENSG00000176890homo_sapiensENSP0000031564499.041597.4441macaca_fascicularisENSMFAP0000004397599.041597.4441
ENSG00000176890homo_sapiensENSP0000031564499.041597.7636macaca_mulattaENSMMUP0000000540599.041597.7636
ENSG00000176890homo_sapiensENSP0000031564499.041597.7636macaca_nemestrinaENSMNEP0000003184999.041597.7636
ENSG00000176890homo_sapiensENSP0000031564499.041597.7636papio_anubisENSPANP0000005082599.041597.7636
ENSG00000176890homo_sapiensENSP0000031564452.076751.1182mandrillus_leucophaeusENSMLEP0000001777310098.1595
ENSG00000176890homo_sapiensENSP0000031564496.805192.9712tursiops_truncatusENSTTRP0000001580496.190592.381
ENSG00000176890homo_sapiensENSP0000031564494.888290.4153vulpes_vulpesENSVVUP0000000570594.58690.1274
ENSG00000176890homo_sapiensENSP0000031564452.076749.2013mus_spretusMGP_SPRETEiJ_P006974393.142988
ENSG00000176890homo_sapiensENSP0000031564482.108675.3994equus_asinusENSEASP0000500351982.108675.3994
ENSG00000176890homo_sapiensENSP0000031564494.888291.3738capra_hircusENSCHIP0000000007183.66280.5634
ENSG00000176890homo_sapiensENSP0000031564492.651889.1374loxodonta_africanaENSLAFP0000001248695.08291.4754
ENSG00000176890homo_sapiensENSP0000031564495.527291.0543panthera_leoENSPLOP0000002339192.857188.5093
ENSG00000176890homo_sapiensENSP0000031564496.166191.3738ailuropoda_melanoleucaENSAMEP0000003606495.253290.5063
ENSG00000176890homo_sapiensENSP0000031564494.888290.4153bos_indicus_hybridENSBIXP0000503333083.898379.9435
ENSG00000176890homo_sapiensENSP0000031564425.559124.2812oryctolagus_cuniculusENSOCUP0000004298781.632777.551
ENSG00000176890homo_sapiensENSP0000031564495.527291.6933oryctolagus_cuniculusENSOCUP0000000748396.451692.5806
ENSG00000176890homo_sapiensENSP0000031564482.108675.7188equus_caballusENSECAP0000008196282.108675.7188
ENSG00000176890homo_sapiensENSP0000031564492.332388.1789canis_lupus_familiarisENSCAFP0084500271488.923184.9231
ENSG00000176890homo_sapiensENSP0000031564494.888290.4153panthera_pardusENSPPRP0000002412894.888290.4153
ENSG00000176890homo_sapiensENSP0000031564494.888291.6933marmota_marmota_marmotaENSMMMP0000001188395.192391.9872
ENSG00000176890homo_sapiensENSP0000031564484.98482.4281balaenoptera_musculusENSBMSP0001002010892.361189.5833
ENSG00000176890homo_sapiensENSP0000031564496.166193.2907balaenoptera_musculusENSBMSP0001001742995.555692.6984
ENSG00000176890homo_sapiensENSP0000031564493.610286.5815cavia_porcellusENSCPOP0000001404393.312186.3057
ENSG00000176890homo_sapiensENSP0000031564495.527290.7348felis_catusENSFCAP0000000855694.620389.8734
ENSG00000176890homo_sapiensENSP0000031564477.316371.885ursus_americanusENSUAMP0000000265770.760265.7895
ENSG00000176890homo_sapiensENSP0000031564450.798747.2843monodelphis_domesticaENSMODP0000002683696.363689.697
ENSG00000176890homo_sapiensENSP0000031564429.073523.9617monodelphis_domesticaENSMODP0000006001559.477149.0196
ENSG00000176890homo_sapiensENSP0000031564479.552774.4409bison_bison_bisonENSBBBP0000001391677.089872.1362
ENSG00000176890homo_sapiensENSP0000031564496.166192.9712monodon_monocerosENSMMNP0001500406295.555692.381
ENSG00000176890homo_sapiensENSP0000031564497.124693.9297sus_scrofaENSSSCP000000426498077.3684
ENSG00000176890homo_sapiensENSP0000031564495.527291.6933microcebus_murinusENSMICP0000002804795.527291.6933
ENSG00000176890homo_sapiensENSP0000031564490.095885.3035octodon_degusENSODEP0000000856693.069388.1188
ENSG00000176890homo_sapiensENSP0000031564486.26279.8722octodon_degusENSODEP0000000696891.836785.034
ENSG00000176890homo_sapiensENSP0000031564491.693387.5399jaculus_jaculusENSJJAP0000001987592.880388.6731
ENSG00000176890homo_sapiensENSP0000031564494.888291.3738ovis_aries_rambouilletENSOARP0002001084294.285790.7936
ENSG00000176890homo_sapiensENSP0000031564476.996872.8435ursus_maritimusENSUMAP0000002708395.256990.1186
ENSG00000176890homo_sapiensENSP0000031564494.888289.7764ochotona_princepsENSOPRP0000000546494.888289.7764
ENSG00000176890homo_sapiensENSP0000031564496.485693.2907delphinapterus_leucasENSDLEP0000000143882.739780
ENSG00000176890homo_sapiensENSP0000031564496.485693.6102physeter_catodonENSPCTP0000502577595.87393.0159
ENSG00000176890homo_sapiensENSP0000031564452.076748.5623mus_caroliMGP_CAROLIEiJ_P006711593.142986.8571
ENSG00000176890homo_sapiensENSP0000031564493.290788.8179mus_musculusENSMUSP0000002684695.11490.5537
ENSG00000176890homo_sapiensENSP0000031564490.734885.3035dipodomys_ordiiENSDORP0000001816695.945990.2027
ENSG00000176890homo_sapiensENSP0000031564495.846692.3323mustela_putorius_furoENSMPUP0000000538094.339690.8805
ENSG00000176890homo_sapiensENSP0000031564498.083195.2077aotus_nancymaaeENSANAP0000003872698.083195.2077
ENSG00000176890homo_sapiensENSP0000031564498.402695.8466saimiri_boliviensis_boliviensisENSSBOP0000000906998.402695.8466
ENSG00000176890homo_sapiensENSP0000031564472.52469.3291vicugna_pacosENSVPAP0000000523872.756469.5513
ENSG00000176890homo_sapiensENSP0000031564499.041597.7636chlorocebus_sabaeusENSCSAP0000001364799.041597.7636
ENSG00000176890homo_sapiensENSP0000031564468.370663.8978tupaia_belangeriENSTBEP0000000063078.676573.5294
ENSG00000176890homo_sapiensENSP0000031564452.396249.2013mesocricetus_auratusENSMAUP0000000554593.714388
ENSG00000176890homo_sapiensENSP0000031564496.485693.2907phocoena_sinusENSPSNP0000001686495.569692.4051
ENSG00000176890homo_sapiensENSP0000031564491.373887.2204camelus_dromedariusENSCDRP0000500425690.793686.6667
ENSG00000176890homo_sapiensENSP0000031564496.805193.2907camelus_dromedariusENSCDRP0000502985896.805193.2907
ENSG00000176890homo_sapiensENSP0000031564496.485693.6102carlito_syrichtaENSTSYP0000002616296.485693.6102
ENSG00000176890homo_sapiensENSP0000031564476.677373.8019panthera_tigris_altaicaENSPTIP0000002200876.677373.8019
ENSG00000176890homo_sapiensENSP0000031564492.971288.1789rattus_norvegicusENSRNOP0000005308694.788389.9023
ENSG00000176890homo_sapiensENSP0000031564495.527292.0128prolemur_simusENSPSMP0000003403795.527292.0128
ENSG00000176890homo_sapiensENSP0000031564492.332386.5815microtus_ochrogasterENSMOCP0000002748295.379589.4389
ENSG00000176890homo_sapiensENSP0000031564482.747675.7188microtus_ochrogasterENSMOCP0000002097792.584.6429
ENSG00000176890homo_sapiensENSP0000031564476.357872.8435sorex_araneusENSSARP0000001119098.353993.8272
ENSG00000176890homo_sapiensENSP0000031564494.888289.4569peromyscus_maniculatus_bairdiiENSPEMP0000002663996.742791.2052
ENSG00000176890homo_sapiensENSP0000031564486.90182.7476bos_mutusENSBMUP0000003001686.90182.7476
ENSG00000176890homo_sapiensENSP0000031564493.290788.8179mus_spicilegusENSMSIP0000001471795.11490.5537
ENSG00000176890homo_sapiensENSP0000031564473.482465.1757cricetulus_griseus_chok1gshdENSCGRP0000101614784.870875.2768
ENSG00000176890homo_sapiensENSP0000031564494.249288.8179cricetulus_griseus_chok1gshdENSCGRP0000100577296.091290.5537
ENSG00000176890homo_sapiensENSP0000031564482.747677.3163pteropus_vampyrusENSPVAP0000000066383.012877.5641
ENSG00000176890homo_sapiensENSP0000031564494.249290.0958myotis_lucifugusENSMLUP0000000873185.755881.9767
ENSG00000176890homo_sapiensENSP0000031564491.693384.984vombatus_ursinusENSVURP0001001387492.580685.8064
ENSG00000176890homo_sapiensENSP0000031564489.776482.7476vombatus_ursinusENSVURP0001002350890.938583.8188
ENSG00000176890homo_sapiensENSP0000031564427.47622.3642vombatus_ursinusENSVURP0001002526068.25455.5556
ENSG00000176890homo_sapiensENSP0000031564492.971285.9425vombatus_ursinusENSVURP0001003030390.654283.8006
ENSG00000176890homo_sapiensENSP0000031564495.527290.7348rhinolophus_ferrumequinumENSRFEP0001002639095.833391.0256
ENSG00000176890homo_sapiensENSP0000031564493.929789.1374neovison_visonENSNVIP0000000550593.03888.2911
ENSG00000176890homo_sapiensENSP0000031564426.517624.9201neovison_visonENSNVIP0000001113075.454570.9091
ENSG00000176890homo_sapiensENSP0000031564495.846692.3323neovison_visonENSNVIP0000002163094.936791.4557
ENSG00000176890homo_sapiensENSP0000031564494.888290.4153bos_taurusENSBTAP0000000921483.898379.9435
ENSG00000176890homo_sapiensENSP0000031564490.095885.3035bos_taurusENSBTAP000000717749489
ENSG00000176890homo_sapiensENSP0000031564493.290785.623heterocephalus_glaber_femaleENSHGLP0000000484194.193686.4516
ENSG00000176890homo_sapiensENSP0000031564499.36198.0831rhinopithecus_bietiENSRBIP0000003405499.36198.0831
ENSG00000176890homo_sapiensENSP0000031564495.207791.0543canis_lupus_dingoENSCAFP0002002272194.904590.7643
ENSG00000176890homo_sapiensENSP0000031564483.386677.9553sciurus_vulgarisENSSVLP0000501619686.71181.0631
ENSG00000176890homo_sapiensENSP0000031564495.527292.0128sciurus_vulgarisENSSVLP0000502856695.527292.0128
ENSG00000176890homo_sapiensENSP0000031564481.469777.3163sciurus_vulgarisENSSVLP0000501614991.397986.7383
ENSG00000176890homo_sapiensENSP0000031564487.539980.5112phascolarctos_cinereusENSPCIP0000001335191.333384
ENSG00000176890homo_sapiensENSP0000031564441.85338.0192phascolarctos_cinereusENSPCIP0000002055870.053563.6364
ENSG00000176890homo_sapiensENSP0000031564423.961720.7668phascolarctos_cinereusENSPCIP0000004825178.947468.4211
ENSG00000176890homo_sapiensENSP0000031564455.910555.5911procavia_capensisENSPCAP0000001508471.721371.3115
ENSG00000176890homo_sapiensENSP0000031564495.207791.6933nannospalax_galiliENSNGAP0000002641097.068493.4853
ENSG00000176890homo_sapiensENSP0000031564491.054385.9425bos_grunniensENSBGRP0000002503793.7588.4868
ENSG00000176890homo_sapiensENSP0000031564493.929789.4569bos_grunniensENSBGRP0000003140293.630689.172
ENSG00000176890homo_sapiensENSP0000031564480.191774.7604chinchilla_lanigeraENSCLAP0000001663087.762281.8182
ENSG00000176890homo_sapiensENSP0000031564496.166192.3323cervus_hanglu_yarkandensisENSCHYP0000002635095.555691.746
ENSG00000176890homo_sapiensENSP0000031564497.444193.6102catagonus_wagneriENSCWAP0000000925597.133893.3121
ENSG00000176890homo_sapiensENSP0000031564457.827553.3546ictidomys_tridecemlineatusENSSTOP0000000081483.027576.6055
ENSG00000176890homo_sapiensENSP0000031564496.805193.2907otolemur_garnettiiENSOGAP0000002131396.805193.2907
ENSG00000176890homo_sapiensENSP0000031564498.083195.2077cebus_imitatorENSCCAP0000003564598.083195.2077
ENSG00000176890homo_sapiensENSP0000031564495.846692.0128moschus_moschiferusENSMMSP0000001278395.238191.4286
ENSG00000176890homo_sapiensENSP0000031564499.041597.7636rhinopithecus_roxellanaENSRROP0000001900099.041597.7636
ENSG00000176890homo_sapiensENSP0000031564451.757248.5623mus_pahariMGP_PahariEiJ_P004855392.571486.8571
ENSG00000176890homo_sapiensENSP0000031564495.846691.6933propithecus_coquereliENSPCOP0000002360995.846691.6933
ENSG00000176890homo_sapiensENSP0000031564472.843562.3003caenorhabditis_elegansY110A7A.4.173.076962.5
ENSG00000176890homo_sapiensENSP0000031564476.038362.6198drosophila_melanogasterFBpp007736374.143361.0592
ENSG00000176890homo_sapiensENSP0000031564425.239622.0447ciona_intestinalisENSCINP0000001075283.157972.6316
ENSG00000176890homo_sapiensENSP0000031564483.067172.524petromyzon_marinusENSPMAP0000000758383.067172.524
ENSG00000176890homo_sapiensENSP0000031564473.801964.2173eptatretus_burgeriENSEBUP0000002733088.846277.3077
ENSG00000176890homo_sapiensENSP0000031564437.060733.5463callorhinchus_miliiENSCMIP0000003856493.548484.6774
ENSG00000176890homo_sapiensENSP0000031564484.025672.524latimeria_chalumnaeENSLACP0000001851885.113373.4628
ENSG00000176890homo_sapiensENSP0000031564487.220477.3163lepisosteus_oculatusENSLOCP0000001349081.008971.8101
ENSG00000176890homo_sapiensENSP0000031564472.204563.5783clupea_harengusENSCHAP0000000949762.952655.4318
ENSG00000176890homo_sapiensENSP0000031564485.303576.0383danio_rerioENSDARP0000004706883.962374.8428
ENSG00000176890homo_sapiensENSP0000031564484.98475.0799carassius_auratusENSCARP0000012005984.444474.6032
ENSG00000176890homo_sapiensENSP0000031564487.859479.5527astyanax_mexicanusENSAMXP0000000744083.333375.4545
ENSG00000176890homo_sapiensENSP0000031564488.817978.2748ictalurus_punctatusENSIPUP0000000966987.697277.2871
ENSG00000176890homo_sapiensENSP0000031564486.26277.3163esox_luciusENSELUP0000000785084.639575.8621
ENSG00000176890homo_sapiensENSP0000031564477.635868.0511electrophorus_electricusENSEEEP0000000221976.175666.7712
ENSG00000176890homo_sapiensENSP0000031564423.003219.1693oncorhynchus_kisutchENSOKIP0000504837469.902958.2524
ENSG00000176890homo_sapiensENSP0000031564485.942576.6773oncorhynchus_mykissENSOMYP0000003962184.32675.2351
ENSG00000176890homo_sapiensENSP0000031564455.910546.3259salmo_salarENSSSAP0000008989966.539955.1331
ENSG00000176890homo_sapiensENSP0000031564482.747675.0799salmo_salarENSSSAP0000009846887.796679.661
ENSG00000176890homo_sapiensENSP0000031564485.942576.3578salmo_truttaENSSTUP0000000026784.32674.9216
ENSG00000176890homo_sapiensENSP0000031564451.757242.492salmo_truttaENSSTUP0000003716367.782455.6485
ENSG00000176890homo_sapiensENSP0000031564485.303576.3578gadus_morhuaENSGMOP0000000575284.493775.6329
ENSG00000176890homo_sapiensENSP0000031564476.038365.8147fundulus_heteroclitusENSFHEP0000001095272.782962.9969
ENSG00000176890homo_sapiensENSP0000031564484.664575.0799poecilia_reticulataENSPREP0000001129282.298172.9814
ENSG00000176890homo_sapiensENSP0000031564485.303574.7604xiphophorus_maculatusENSXMAP0000000224283.177672.8972
ENSG00000176890homo_sapiensENSP0000031564479.872271.885oryzias_latipesENSORLP0000001387786.805678.125
ENSG00000176890homo_sapiensENSP0000031564486.90176.6773cyclopterus_lumpusENSCLMP0000504774382.674872.9483
ENSG00000176890homo_sapiensENSP0000031564484.98476.6773oreochromis_niloticusENSONIP0000000766281.846273.8462
ENSG00000176890homo_sapiensENSP0000031564484.664576.6773haplochromis_burtoniENSHBUP0000001481081.538573.8462
ENSG00000176890homo_sapiensENSP0000031564475.399466.4537astatotilapia_callipteraENSACLP0000000161471.299162.8399
ENSG00000176890homo_sapiensENSP0000031564485.942576.9968sparus_aurataENSSAUP0001002639567.082360.0998
ENSG00000176890homo_sapiensENSP0000031564481.469773.1629lates_calcariferENSLCAP0001001096878.947470.8978
ENSG00000176890homo_sapiensENSP0000031564487.220479.2332xenopus_tropicalisENSXETP0000000686088.636480.5195
ENSG00000176890homo_sapiensENSP0000031564476.038367.4121chrysemys_picta_belliiENSCPBP0000004005486.545576.7273
ENSG00000176890homo_sapiensENSP0000031564457.50853.0351sphenodon_punctatusENSSPUP0000002234186.956580.1932
ENSG00000176890homo_sapiensENSP0000031564490.415383.3866sphenodon_punctatusENSSPUP0000000924193.092185.8553
ENSG00000176890homo_sapiensENSP0000031564488.178981.4697crocodylus_porosusENSCPRP0000501828290.789583.8816
ENSG00000176890homo_sapiensENSP0000031564449.840344.0895laticauda_laticaudataENSLLTP0000000031194.545583.6364
ENSG00000176890homo_sapiensENSP0000031564488.498478.5942notechis_scutatusENSNSUP0000002700388.498478.5942
ENSG00000176890homo_sapiensENSP0000031564486.581576.9968pseudonaja_textilisENSPTXP0000000984879.239870.4678
ENSG00000176890homo_sapiensENSP0000031564487.859481.4697anas_platyrhynchos_platyrhynchosENSAPLP0000001554690.460583.8816
ENSG00000176890homo_sapiensENSP0000031564479.872270.2875gallus_gallusENSGALP0001000530882.781572.8477
ENSG00000176890homo_sapiensENSP0000031564472.204563.8978meleagris_gallopavoENSMGAP0000002188877.397368.4931
ENSG00000176890homo_sapiensENSP0000031564486.26278.2748serinus_canariaENSSCAP0000001338088.235380.0654
ENSG00000176890homo_sapiensENSP0000031564487.859479.8722parus_majorENSPMJP0000001962091.059682.7815
ENSG00000176890homo_sapiensENSP0000031564488.817981.4697anolis_carolinensisENSACAP0000000829790.553783.0619
ENSG00000176890homo_sapiensENSP0000031564484.664576.0383neolamprologus_brichardiENSNBRP0000001940578.86970.8333
ENSG00000176890homo_sapiensENSP0000031564487.859478.2748naja_najaENSNNAP0000002659187.859478.2748
ENSG00000176890homo_sapiensENSP0000031564488.178978.9137podarcis_muralisENSPMRP0000000852589.320479.9353
ENSG00000176890homo_sapiensENSP0000031564487.220479.5527geospiza_fortisENSGFOP0000000638890.397482.4503
ENSG00000176890homo_sapiensENSP0000031564488.178979.8722taeniopygia_guttataENSTGUP0000001050380.466572.8863
ENSG00000176890homo_sapiensENSP0000031564486.26276.6773erpetoichthys_calabaricusENSECRP0000001088285.173575.7098
ENSG00000176890homo_sapiensENSP0000031564485.303577.3163kryptolebias_marmoratusENSKMAP0000001904384.227176.3407
ENSG00000176890homo_sapiensENSP0000031564486.26278.2748salvator_merianaeENSSMRP0000002131387.096879.0323
ENSG00000176890homo_sapiensENSP0000031564462.300350.7987oryzias_javanicusENSOJAP0000003013451.047141.623
ENSG00000176890homo_sapiensENSP0000031564486.581575.7188amphilophus_citrinellusENSACIP0000002099579.94169.9115
ENSG00000176890homo_sapiensENSP0000031564485.62376.3578dicentrarchus_labraxENSDLAP0000504245182.208673.3129
ENSG00000176890homo_sapiensENSP0000031564486.90176.9968amphiprion_perculaENSAPEP0000002094385.266575.5486
ENSG00000176890homo_sapiensENSP0000031564484.025675.7188oryzias_sinensisENSOSIP0000002450682.187574.0625
ENSG00000176890homo_sapiensENSP0000031564449.840346.6454pelodiscus_sinensisENSPSIP0000000825794.545588.4848
ENSG00000176890homo_sapiensENSP0000031564487.859480.5112gopherus_evgoodeiENSGEVP0000500547492.592684.8485
ENSG00000176890homo_sapiensENSP0000031564488.817981.1502chelonoidis_abingdoniiENSCABP0000002608892.666784.6667
ENSG00000176890homo_sapiensENSP0000031564485.942576.6773seriola_dumeriliENSSDUP0000001076083.800674.7664
ENSG00000176890homo_sapiensENSP0000031564485.942576.0383cottoperca_gobioENSCGOP0000001401284.062574.375
ENSG00000176890homo_sapiensENSP0000031564440.255635.1438struthio_camelus_australisENSSCUP000000073417565.4762
ENSG00000176890homo_sapiensENSP0000031564487.220481.4697anser_brachyrhynchusENSABRP0000002282859.737455.7987
ENSG00000176890homo_sapiensENSP0000031564482.747676.6773gasterosteus_aculeatusENSGACP0000000541489.310382.7586
ENSG00000176890homo_sapiensENSP0000031564484.34574.7604cynoglossus_semilaevisENSCSEP000000005866053.1818
ENSG00000176890homo_sapiensENSP0000031564484.98476.0383poecilia_formosaENSPFOP0000002982082.608773.913
ENSG00000176890homo_sapiensENSP0000031564484.34574.7604myripristis_murdjanENSMMDP0000501394882.573.125
ENSG00000176890homo_sapiensENSP0000031564486.26277.3163sander_luciopercaENSSLUP0000005531580.357172.0238
ENSG00000176890homo_sapiensENSP0000031564487.859480.8307strigops_habroptilaENSSHBP0000501096193.220385.7627
ENSG00000176890homo_sapiensENSP0000031564486.90176.6773amphiprion_ocellarisENSAOCP0000001758085.266575.2351
ENSG00000176890homo_sapiensENSP0000031564488.817981.7891terrapene_carolina_triunguisENSTMTP0000002824461.504456.6372
ENSG00000176890homo_sapiensENSP0000031564449.840342.492hucho_huchoENSHHUP0000004428782.978770.7447
ENSG00000176890homo_sapiensENSP0000031564486.581577.6358hucho_huchoENSHHUP0000001797679.94171.6814
ENSG00000176890homo_sapiensENSP0000031564485.303578.2748betta_splendensENSBSLP0000001021383.177676.324
ENSG00000176890homo_sapiensENSP0000031564487.220478.2748pygocentrus_nattereriENSPNAP0000000138785.312576.5625
ENSG00000176890homo_sapiensENSP0000031564486.90178.5942anabas_testudineusENSATEP0000005155378.160970.6897
ENSG00000176890homo_sapiensENSP0000031564478.913768.6901ciona_savignyiENSCSAVP0000000883678.913768.6901
ENSG00000176890homo_sapiensENSP0000031564472.204559.7444saccharomyces_cerevisiaeYOR074C74.342161.5132
ENSG00000176890homo_sapiensENSP0000031564485.62376.6773seriola_lalandi_dorsalisENSSLDP0000002710883.489174.7664
ENSG00000176890homo_sapiensENSP0000031564446.645442.492seriola_lalandi_dorsalisENSSLDP0000000686990.683282.6087
ENSG00000176890homo_sapiensENSP0000031564485.942576.6773labrus_bergyltaENSLBEP0000002175582.769273.8462
ENSG00000176890homo_sapiensENSP0000031564481.469772.2045pundamilia_nyerereiENSPNYP0000000141978.220969.3252
ENSG00000176890homo_sapiensENSP0000031564484.34575.0799mastacembelus_armatusENSMAMP0000006304682.24373.2087
ENSG00000176890homo_sapiensENSP0000031564487.859477.9553stegastes_partitusENSSPAP0000001498885.403775.7764
ENSG00000176890homo_sapiensENSP0000031564438.658128.4345oncorhynchus_tshawytschaENSOTSP0000501928967.222249.4444
ENSG00000176890homo_sapiensENSP0000031564486.26276.3578acanthochromis_polyacanthusENSAPOP0000003046384.905775.1572
ENSG00000176890homo_sapiensENSP0000031564487.539981.4697aquila_chrysaetos_chrysaetosENSACCP0002001079690.728584.4371
ENSG00000176890homo_sapiensENSP0000031564484.025674.1214nothobranchius_furzeriENSNFUP0001501162068.668460.5744
ENSG00000176890homo_sapiensENSP0000031564484.98476.6773cyprinodon_variegatusENSCVAP0000000534883.12575
ENSG00000176890homo_sapiensENSP0000031564450.479245.3674cyprinodon_variegatusENSCVAP0000000213591.329582.0809
ENSG00000176890homo_sapiensENSP0000031564484.025674.7604denticeps_clupeoidesENSDCDP0000001856684.025674.7604
ENSG00000176890homo_sapiensENSP0000031564486.90178.2748larimichthys_croceaENSLCRP0000506026281.437173.3533
ENSG00000176890homo_sapiensENSP0000031564474.760465.4952takifugu_rubripesENSTRUP000000493177263.0769
ENSG00000176890homo_sapiensENSP0000031564467.092756.5495ficedula_albicollisENSFALP0000002927042.168735.5422
ENSG00000176890homo_sapiensENSP0000031564483.706175.3994hippocampus_comesENSHCOP0000001075684.516176.129
ENSG00000176890homo_sapiensENSP0000031564484.98475.7188cyprinus_carpio_carpioENSCCRP0000014679153.306647.495
ENSG00000176890homo_sapiensENSP0000031564444.089538.0192cyprinus_carpio_carpioENSCCRP0000015724790.196177.7778
ENSG00000176890homo_sapiensENSP0000031564486.90180.1917coturnix_japonicaENSCJPP0000501066992.51785.3742
ENSG00000176890homo_sapiensENSP0000031564484.98476.0383poecilia_latipinnaENSPLAP0000001688382.608773.913
ENSG00000176890homo_sapiensENSP0000031564473.801964.2173sinocyclocheilus_grahamiENSSGRP0000005027575.737765.9016
ENSG00000176890homo_sapiensENSP0000031564473.482463.5783sinocyclocheilus_grahamiENSSGRP0000000686674.193664.1936
ENSG00000176890homo_sapiensENSP0000031564484.98476.6773maylandia_zebraENSMZEP0000500178681.846273.8462
ENSG00000176890homo_sapiensENSP0000031564485.62375.3994paramormyrops_kingsleyaeENSPKIP0000002958785.62375.3994
ENSG00000176890homo_sapiensENSP0000031564486.581577.3163scleropages_formosusENSSFOP0001500196484.95375.8621
ENSG00000176890homo_sapiensENSP0000031564482.108669.0096leptobrachium_leishanenseENSLLEP0000003155325.024321.0321
ENSG00000176890homo_sapiensENSP0000031564429.712524.6006scophthalmus_maximusENSSMAP0000006047170.992458.7786
ENSG00000176890homo_sapiensENSP0000031564485.303576.6773scophthalmus_maximusENSSMAP0000003762778.299170.3812
ENSG00000176890homo_sapiensENSP0000031564484.34575.7188oryzias_melastigmaENSOMEP0000002329682.574.0625

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000900enables mRNA regulatory element binding translation repressor activity1IDAHomo_sapiens(9606)Function
GO:0004799enables thymidylate synthase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005542enables folic acid binding1ICHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005739is_active_in mitochondrion2IBA,IDAHomo_sapiens(9606)Component
GO:0005743located_in mitochondrial inner membrane1IDAHomo_sapiens(9606)Component
GO:0005759located_in mitochondrial matrix1IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0006231involved_in dTMP biosynthetic process2IBA,IDAHomo_sapiens(9606)Process
GO:0006235involved_in dTTP biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0007623involved_in circadian rhythm1IEAHomo_sapiens(9606)Process
GO:0009410involved_in response to xenobiotic stimulus1IEAHomo_sapiens(9606)Process
GO:0009636involved_in response to toxic substance1IEAHomo_sapiens(9606)Process
GO:0017148involved_in negative regulation of translation1IDAHomo_sapiens(9606)Process
GO:0019860involved_in uracil metabolic process1IEAHomo_sapiens(9606)Process
GO:0032259involved_in methylation1IEAHomo_sapiens(9606)Process
GO:0032570involved_in response to progesterone1IEAHomo_sapiens(9606)Process
GO:0033189involved_in response to vitamin A1IEAHomo_sapiens(9606)Process
GO:0034097involved_in response to cytokine1IEAHomo_sapiens(9606)Process
GO:0035999involved_in tetrahydrofolate interconversion1IDAHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1IEAHomo_sapiens(9606)Function
GO:0045471involved_in response to ethanol1IEAHomo_sapiens(9606)Process
GO:0046683involved_in response to organophosphorus1IEPHomo_sapiens(9606)Process
GO:0048589involved_in developmental growth1IEAHomo_sapiens(9606)Process
GO:0051216involved_in cartilage development1IEAHomo_sapiens(9606)Process
GO:0051384involved_in response to glucocorticoid1IEAHomo_sapiens(9606)Process
GO:0051593involved_in response to folic acid1IEAHomo_sapiens(9606)Process
GO:0060574involved_in intestinal epithelial cell maturation1IEAHomo_sapiens(9606)Process
GO:0071897involved_in DNA biosynthetic process1ICHomo_sapiens(9606)Process
GO:0097421involved_in liver regeneration1IEAHomo_sapiens(9606)Process
GO:1990825enables sequence-specific mRNA binding1IDAHomo_sapiens(9606)Function

Expression