Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000176887 Gene ID 6664 Accession 11191
Symbol SOX11 Alias CSS9;MRD27;IDDMOH Full Name SRY-box transcription factor 11
Status Confidence Length 9002 bases Strand Plus strand
Position 2 : 5692384 - 5701385 RNA binding domain N.A.
Summary This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
30134837 Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11. Zhun Wu 2018-07-31 Molecular medicine (Cambridge, Mass.)
36910334 lncRNA CYTOR Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Modulating SOX11 via Sponging miR-6512-3p. Shaoqin Tu 2023-01-01 Stem cells international

Transcripts

Name Transcript ID bp Protein Translation ID
SOX11-201 ENST00000322002 9002 441aa ENSP00000322568

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
6037Hemoglobins3.2350917035992E-817903294
6051Hemoglobins2.77992991934036E-817903294
6113Hemoglobins3.06257351105486E-817903294
6127Hemoglobins2.21594925587019E-917903294
6273Erythrocytes1.03042639411184E-817903294
7701Glomerular Filtration Rate7.18949289146842E-617903292
7716Glomerular Filtration Rate2.48673758944662E-517903292
7726Creatinine2.54242746434832E-517903292
7742Creatinine6.49678632189978E-517903292
22481Body Mass Index1.1850000E-005-
24098Body Fat Distribution9.7220000E-005-
37680Platelet Function Tests1.5300000E-007-
37693Platelet Function Tests4.8700000E-006-
62428Vascular Calcification5E-623870195
89502Renal Insufficiency, Chronic2E-720383146

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II2IBA,IDAHomo_sapiens(9606)Process
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding1ISSHomo_sapiens(9606)Function
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific1ISAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific2IBA,ISSHomo_sapiens(9606)Function
GO:0001822involved_in kidney development1IEAHomo_sapiens(9606)Process
GO:0002089involved_in lens morphogenesis in camera-type eye1ISSHomo_sapiens(9606)Process
GO:0003151involved_in outflow tract morphogenesis1ISSHomo_sapiens(9606)Process
GO:0003357involved_in noradrenergic neuron differentiation1ISSHomo_sapiens(9606)Process
GO:0003700enables DNA-binding transcription factor activity1ISSHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0007399involved_in nervous system development1ISSHomo_sapiens(9606)Process
GO:0009653involved_in anatomical structure morphogenesis1IBAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0014003involved_in oligodendrocyte development1IEAHomo_sapiens(9606)Process
GO:0014009involved_in glial cell proliferation1ISSHomo_sapiens(9606)Process
GO:0017015involved_in regulation of transforming growth factor beta receptor signaling pathway1IEPHomo_sapiens(9606)Process
GO:0021510involved_in spinal cord development1ISSHomo_sapiens(9606)Process
GO:0030182involved_in neuron differentiation2IBA,IEPHomo_sapiens(9606)Process
GO:0030513involved_in positive regulation of BMP signaling pathway1ISSHomo_sapiens(9606)Process
GO:0035332involved_in positive regulation of hippo signaling1ISSHomo_sapiens(9606)Process
GO:0035914involved_in skeletal muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0045666involved_in positive regulation of neuron differentiation1IMPHomo_sapiens(9606)Process
GO:0045669involved_in positive regulation of osteoblast differentiation1IMPHomo_sapiens(9606)Process
GO:0045778involved_in positive regulation of ossification1IMPHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II3IBA,IDA,ISSHomo_sapiens(9606)Process
GO:0046887involved_in positive regulation of hormone secretion1ISSHomo_sapiens(9606)Process
GO:0048485involved_in sympathetic nervous system development1ISSHomo_sapiens(9606)Process
GO:0048557involved_in embryonic digestive tract morphogenesis1ISSHomo_sapiens(9606)Process
GO:0048704involved_in embryonic skeletal system morphogenesis1ISSHomo_sapiens(9606)Process
GO:0050672involved_in negative regulation of lymphocyte proliferation1IMPHomo_sapiens(9606)Process
GO:0050769involved_in positive regulation of neurogenesis1ISSHomo_sapiens(9606)Process
GO:0060022involved_in hard palate development1ISSHomo_sapiens(9606)Process
GO:0060023involved_in soft palate development1ISSHomo_sapiens(9606)Process
GO:0060253involved_in negative regulation of glial cell proliferation1IMPHomo_sapiens(9606)Process
GO:0060412involved_in ventricular septum morphogenesis1ISSHomo_sapiens(9606)Process
GO:0060425involved_in lung morphogenesis1ISSHomo_sapiens(9606)Process
GO:0060563involved_in neuroepithelial cell differentiation1ISSHomo_sapiens(9606)Process
GO:0061029involved_in eyelid development in camera-type eye1ISSHomo_sapiens(9606)Process
GO:0061303involved_in cornea development in camera-type eye1ISSHomo_sapiens(9606)Process
GO:0061386involved_in closure of optic fissure1ISSHomo_sapiens(9606)Process
GO:2000648involved_in positive regulation of stem cell proliferation1IMPHomo_sapiens(9606)Process
GO:2000678involved_in negative regulation of transcription regulatory region DNA binding1ISSHomo_sapiens(9606)Process
GO:2001111involved_in positive regulation of lens epithelial cell proliferation1ISSHomo_sapiens(9606)Process

Expression