Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000175793 Gene ID 2810 Accession 10773
Symbol SFN Alias YWHAS Full Name stratifin
Status Confidence Length 1308 bases Strand Plus strand
Position 1 : 26863149 - 26864456 RNA binding domain N.A.
Summary This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SFN-201 ENST00000339276 1308 248aa ENSP00000340989

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000079involved_in regulation of cyclin-dependent protein serine/threonine kinase activity1IEAHomo_sapiens(9606)Process
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0001836involved_in release of cytochrome c from mitochondria1IDAHomo_sapiens(9606)Process
GO:0003334involved_in keratinocyte development1IEAHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1TASHomo_sapiens(9606)Component
GO:0005634located_in nucleus1IEAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006469involved_in negative regulation of protein kinase activity1TASHomo_sapiens(9606)Process
GO:0006611involved_in protein export from nucleus1IEAHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1IBAHomo_sapiens(9606)Process
GO:0008426enables protein kinase C inhibitor activity1TASHomo_sapiens(9606)Function
GO:0008630involved_in intrinsic apoptotic signaling pathway in response to DNA damage1IDAHomo_sapiens(9606)Process
GO:0010482involved_in regulation of epidermal cell division1ISSHomo_sapiens(9606)Process
GO:0010737involved_in protein kinase A signaling1IEAHomo_sapiens(9606)Process
GO:0010839involved_in negative regulation of keratinocyte proliferation1IEAHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IBAHomo_sapiens(9606)Function
GO:0030307involved_in positive regulation of cell growth1IEAHomo_sapiens(9606)Process
GO:0031424involved_in keratinization1IEAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043154involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process1IDAHomo_sapiens(9606)Process
GO:0043616involved_in keratinocyte proliferation1IEAHomo_sapiens(9606)Process
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0045606involved_in positive regulation of epidermal cell differentiation1ISSHomo_sapiens(9606)Process
GO:0046827involved_in positive regulation of protein export from nucleus1IEAHomo_sapiens(9606)Process
GO:0051219enables phosphoprotein binding1IEAHomo_sapiens(9606)Function
GO:0061436involved_in establishment of skin barrier1ISSHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0072089involved_in stem cell proliferation1IEAHomo_sapiens(9606)Process
GO:2000647involved_in negative regulation of stem cell proliferation1IEAHomo_sapiens(9606)Process

Expression