RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	FlavivirusesSARS-COV-2DengueZika
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	DUB
Localizations	Stress granucle
BulkPerturb-seq

Description

Ensembl ID	ENSG00000175390	Gene ID	8665	Accession	3275
Symbol	EIF3F	Alias	MRT67;EIF3S5;eIF3-p47	Full Name	eukaryotic translation initiation factor 3 subunit F
Status	Confidence	Length	31612 bases	Strand	Plus strand
Position	11 : 7970251 - 8001862	RNA binding domain	N.A.
Summary	Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
22457825	The tumor suppressive role of eIF3f and its function in translation inhibition and rRNA degradation.	Fushi Wen	2012-01-01	PloS one
23354061	The translational factor eIF3f: the ambivalent eIF3 subunit.	Roberta Marchione	2013-10-01	Cellular and molecular life sciences : CMLS
37155573	eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.	Haoran Duan	2023-06-15	The EMBO journal
32638509	The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic intervention.	G David Maranon	2020-09-01	Wiley interdisciplinary reviews. RNA
19854136	HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8.	T Susana Valente	2009-10-23	Molecular cell

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
EIF3F-207	ENST00000533626	7540	357aa	ENSP00000431800
EIF3F-205	ENST00000531572	1784	359aa	ENSP00000434286
EIF3F-208	ENST00000640290	1914	172aa	ENSP00000491198
EIF3F-215	ENST00000678993	6713	124aa	ENSP00000504201
EIF3F-209	ENST00000651655	6920	357aa	ENSP00000499218
EIF3F-210	ENST00000677121	7055	218aa	ENSP00000503130
EIF3F-204	ENST00000531329	844	55aa	ENSP00000432489
EIF3F-214	ENST00000678132	4308	172aa	ENSP00000504073
EIF3F-201	ENST00000528653	1692	No protein	-
EIF3F-211	ENST00000677179	8434	No protein	-
EIF3F-202	ENST00000528763	1988	No protein	-
EIF3F-212	ENST00000677795	3395	No protein	-
EIF3F-206	ENST00000532882	2536	No protein	-
EIF3F-213	ENST00000677866	2229	No protein	-
EIF3F-203	ENST00000530219	1569	No protein	-

Gene Model

Click here to download ENSG00000175390's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
69103	Depressive Disorder	3E-6	20800221

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000175390's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001732	involved_in formation of cytoplasmic translation initiation complex	1	NAS	Homo_sapiens(9606)	Process
GO:0003743	contributes_to translation initiation factor activity	4	IBA,IC,IDA,TAS	Homo_sapiens(9606)	Function
GO:0004843	enables cysteine-type deubiquitinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005852	part_of eukaryotic translation initiation factor 3 complex	3	IDA,IPI,TAS	Homo_sapiens(9606)	Component
GO:0006413	involved_in translational initiation	3	IBA,IC,IDA	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016282	part_of eukaryotic 43S preinitiation complex	1	IEA	Homo_sapiens(9606)	Component
GO:0016579	involved_in protein deubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0031369	enables translation initiation factor binding	1	IBA	Homo_sapiens(9606)	Function
GO:0033290	part_of eukaryotic 48S preinitiation complex	1	IEA	Homo_sapiens(9606)	Component
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0045202	located_in synapse	1	IEA	Homo_sapiens(9606)	Component
GO:0071541	part_of eukaryotic translation initiation factor 3 complex, eIF3m	1	IBA	Homo_sapiens(9606)	Component
GO:0075522	involved_in IRES-dependent viral translational initiation	1	IDA	Homo_sapiens(9606)	Process
GO:0140492	enables metal-dependent deubiquitinase activity	1	IDA	Homo_sapiens(9606)	Function

Expression