RBP Type	Non-canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	ncRNA
Moonlighting functions	Transmemebrane
Localizations	Nucleoli
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000175387	Gene ID	4087	Accession	6768
Symbol	SMAD2	Alias	JV18;LDS6;CHTD8;MADH2;MADR2;JV18-1;hMAD-2;hSMAD2	Full Name	SMAD family member 2
Status	Confidence	Length	122190 bases	Strand	Minus strand
Position	18 : 47808957 - 47931146	RNA binding domain	N.A.
Summary	The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
29304067	Introns provide a platform for intergenic regulatory feedback of RPL22 paralogs in yeast.	Kateřina Abrhámová	2018-01-01	PloS one
29186616	JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.	Anders Sundqvist	2018-02-16	Nucleic acids research
34785655	Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis.	Meng-Zhi Wu	2021-11-17	Signal transduction and targeted therapy

Name	Transcript ID	bp	Protein	Translation ID
SMAD2-201	ENST00000262160	34626	467aa	ENSP00000262160
SMAD2-203	ENST00000402690	12075	467aa	ENSP00000384449
SMAD2-205	ENST00000586040	1971	437aa	ENSP00000466193
SMAD2-212	ENST00000591214	1714	431aa	ENSP00000467075
SMAD2-209	ENST00000587353	584	No protein	-
SMAD2-208	ENST00000587269	1042	217aa	ENSP00000466254
SMAD2-207	ENST00000586514	828	217aa	ENSP00000465355
SMAD2-210	ENST00000587421	575	137aa	ENSP00000468202
SMAD2-206	ENST00000586487	564	No protein	-
SMAD2-211	ENST00000589877	527	109aa	ENSP00000465971
SMAD2-204	ENST00000585978	663	108aa	ENSP00000468732
SMAD2-202	ENST00000356825	10445	437aa	ENSP00000349282

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000175387	homo_sapiens	ENSP00000369154	70.6638	59.9572	homo_sapiens	ENSP00000262160	70.6638	59.9572
ENSG00000175387	homo_sapiens	ENSP00000305769	71.6129	60.8602	homo_sapiens	ENSP00000262160	71.3062	60.5996
ENSG00000175387	homo_sapiens	ENSP00000441954	72.2581	61.0753	homo_sapiens	ENSP00000262160	71.9486	60.8137
ENSG00000175387	homo_sapiens	ENSP00000288840	37.0968	26.4113	homo_sapiens	ENSP00000262160	39.4004	28.0514
ENSG00000175387	homo_sapiens	ENSP00000341551	45.6522	34.4203	homo_sapiens	ENSP00000262160	53.9615	40.6852
ENSG00000175387	homo_sapiens	ENSP00000262158	41.784	26.7606	homo_sapiens	ENSP00000262160	38.1156	24.4111
ENSG00000175387	homo_sapiens	ENSP00000332973	96.4706	92	homo_sapiens	ENSP00000262160	87.7944	83.7259

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	nomascus_leucogenys	ENSNLEP00000023604	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	pan_paniscus	ENSPPAP00000024577	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	pongo_abelii	ENSPPYP00000010275	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	pan_troglodytes	ENSPTRP00000062376	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	gorilla_gorilla	ENSGGOP00000004612	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.1435	ornithorhynchus_anatinus	ENSOANP00000003129	100	99.1435
ENSG00000175387	homo_sapiens	ENSP00000262160	99.1435	98.7152	sarcophilus_harrisii	ENSSHAP00000042045	92.4152	92.016
ENSG00000175387	homo_sapiens	ENSP00000262160	53.9615	53.7473	notamacropus_eugenii	ENSMEUP00000008060	100	99.6032
ENSG00000175387	homo_sapiens	ENSP00000262160	86.9379	86.0814	choloepus_hoffmanni	ENSCHOP00000009988	87.689	86.8251
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	dasypus_novemcinctus	ENSDNOP00000007209	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	91.0064	90.7923	erinaceus_europaeus	ENSEEUP00000007036	99.7653	99.5305
ENSG00000175387	homo_sapiens	ENSP00000262160	70.4497	68.7366	echinops_telfairi	ENSETEP00000014167	88.9189	86.7568
ENSG00000175387	homo_sapiens	ENSP00000262160	93.1478	92.0771	callithrix_jacchus	ENSCJAP00000054125	90.249	89.2116
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	cercocebus_atys	ENSCATP00000001163	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	macaca_fascicularis	ENSMFAP00000029074	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	macaca_mulatta	ENSMMUP00000045810	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	macaca_nemestrina	ENSMNEP00000027973	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	87.152	85.8672	papio_anubis	ENSPANP00000031642	77.6718	76.5267
ENSG00000175387	homo_sapiens	ENSP00000262160	97.8587	97.8587	mandrillus_leucophaeus	ENSMLEP00000027206	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	tursiops_truncatus	ENSTTRP00000002462	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	vulpes_vulpes	ENSVVUP00000039611	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	mus_spretus	MGP_SPRETEiJ_P0049104	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	equus_asinus	ENSEASP00005047804	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	capra_hircus	ENSCHIP00000022106	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	loxodonta_africana	ENSLAFP00000000114	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.7859	panthera_leo	ENSPLOP00000020542	99.7859	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.7859	ailuropoda_melanoleuca	ENSAMEP00000013534	95.112	94.9083
ENSG00000175387	homo_sapiens	ENSP00000262160	88.651	86.7238	bos_indicus_hybrid	ENSBIXP00005025026	65.9236	64.4904
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	oryctolagus_cuniculus	ENSOCUP00000009717	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	89.5075	87.152	equus_caballus	ENSECAP00000059802	78.424	76.3602
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	canis_lupus_familiaris	ENSCAFP00845003314	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.7859	panthera_pardus	ENSPPRP00000004550	99.7859	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.7859	marmota_marmota_marmota	ENSMMMP00000007058	100	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	balaenoptera_musculus	ENSBMSP00010029561	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	cavia_porcellus	ENSCPOP00000012060	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	86.2955	83.2976	felis_catus	ENSFCAP00000057862	55.8946	53.9528
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.7859	ursus_americanus	ENSUAMP00000026566	100	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	monodelphis_domestica	ENSMODP00000012005	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	bison_bison_bison	ENSBBBP00000001361	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	monodon_monoceros	ENSMMNP00015001755	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	sus_scrofa	ENSSSCP00000054408	98.9407	98.9407
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	microcebus_murinus	ENSMICP00000050102	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	octodon_degus	ENSODEP00000025103	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.7859	jaculus_jaculus	ENSJJAP00000021582	99.7859	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	ovis_aries_rambouillet	ENSOARP00020013362	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	95.9315	95.7173	ursus_maritimus	ENSUMAP00000003150	99.7773	99.5546
ENSG00000175387	homo_sapiens	ENSP00000262160	69.1649	68.9508	ochotona_princeps	ENSOPRP00000012826	77.0883	76.8496
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	delphinapterus_leucas	ENSDLEP00000008841	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	physeter_catodon	ENSPCTP00005013419	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	mus_caroli	MGP_CAROLIEiJ_P0047151	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	mus_musculus	ENSMUSP00000130115	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.7859	dipodomys_ordii	ENSDORP00000018085	100	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	mustela_putorius_furo	ENSMPUP00000000846	94.3434	94.3434
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	aotus_nancymaae	ENSANAP00000027490	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	saimiri_boliviensis_boliviensis	ENSSBOP00000040315	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	vicugna_pacos	ENSVPAP00000007238	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	chlorocebus_sabaeus	ENSCSAP00000014035	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	tupaia_belangeri	ENSTBEP00000014002	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	mesocricetus_auratus	ENSMAUP00000004976	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	phocoena_sinus	ENSPSNP00000013642	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	camelus_dromedarius	ENSCDRP00005017860	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.5717	99.1435	carlito_syrichta	ENSTSYP00000004847	99.5717	99.1435
ENSG00000175387	homo_sapiens	ENSP00000262160	97.4304	97.4304	panthera_tigris_altaica	ENSPTIP00000017564	97.4304	97.4304
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.3576	rattus_norvegicus	ENSRNOP00000075341	99.7859	99.3576
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	prolemur_simus	ENSPSMP00000026519	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	microtus_ochrogaster	ENSMOCP00000019753	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	74.0899	73.8758	sorex_araneus	ENSSARP00000003156	74.0899	73.8758
ENSG00000175387	homo_sapiens	ENSP00000262160	99.5717	99.3576	peromyscus_maniculatus_bairdii	ENSPEMP00000023306	99.5717	99.3576
ENSG00000175387	homo_sapiens	ENSP00000262160	99.5717	99.5717	bos_mutus	ENSBMUP00000009459	99.359	99.359
ENSG00000175387	homo_sapiens	ENSP00000262160	99.5717	99.3576	mus_spicilegus	ENSMSIP00000022247	99.5717	99.3576
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	cricetulus_griseus_chok1gshd	ENSCGRP00001004933	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	pteropus_vampyrus	ENSPVAP00000007326	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	myotis_lucifugus	ENSMLUP00000008070	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	vombatus_ursinus	ENSVURP00010000230	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	rhinolophus_ferrumequinum	ENSRFEP00010020808	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	neovison_vison	ENSNVIP00000001684	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	bos_taurus	ENSBTAP00000017649	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	heterocephalus_glaber_female	ENSHGLP00000047605	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	rhinopithecus_bieti	ENSRBIP00000012165	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	48.6081	48.6081	canis_lupus_dingo	ENSCAFP00020012880	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.7859	sciurus_vulgaris	ENSSVLP00005024559	100	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	82.227	80.2998	sciurus_vulgaris	ENSSVLP00005021320	96.7254	94.4584
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	phascolarctos_cinereus	ENSPCIP00000020635	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	81.5846	81.5846	procavia_capensis	ENSPCAP00000011836	95.0125	95.0125
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.7859	nannospalax_galili	ENSNGAP00000011106	99.7859	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.7859	bos_grunniens	ENSBGRP00000035499	99.7859	99.7859
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	chinchilla_lanigera	ENSCLAP00000016366	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	cervus_hanglu_yarkandensis	ENSCHYP00000015282	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	74.5182	72.1627	catagonus_wagneri	ENSCWAP00000027610	96.1326	93.0939
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	catagonus_wagneri	ENSCWAP00000010919	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	ictidomys_tridecemlineatus	ENSSTOP00000003397	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	otolemur_garnettii	ENSOGAP00000000398	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	cebus_imitator	ENSCCAP00000036665	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	urocitellus_parryii	ENSUPAP00010020178	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	100	100	moschus_moschiferus	ENSMMSP00000008742	100	100
ENSG00000175387	homo_sapiens	ENSP00000262160	32.9764	31.9058	moschus_moschiferus	ENSMMSP00000023968	91.1243	88.1657
ENSG00000175387	homo_sapiens	ENSP00000262160	81.5846	81.3705	rhinopithecus_roxellana	ENSRROP00000023441	97.1939	96.9388
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.5717	mus_pahari	MGP_PahariEiJ_P0039719	99.7859	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	95.7173	95.5032	propithecus_coquereli	ENSPCOP00000000517	96.7533	96.5368
ENSG00000175387	homo_sapiens	ENSP00000262160	76.6595	67.666	ciona_intestinalis	ENSCINP00000012794	84.0376	74.1784
ENSG00000175387	homo_sapiens	ENSP00000262160	83.5118	82.0128	callorhinchus_milii	ENSCMIP00000032781	93.5252	91.8465
ENSG00000175387	homo_sapiens	ENSP00000262160	99.3576	98.0728	latimeria_chalumnae	ENSLACP00000008339	99.3576	98.0728
ENSG00000175387	homo_sapiens	ENSP00000262160	98.9293	96.788	lepisosteus_oculatus	ENSLOCP00000015279	98.9293	96.788
ENSG00000175387	homo_sapiens	ENSP00000262160	99.5717	98.7152	xenopus_tropicalis	ENSXETP00000043789	99.5717	98.7152
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	chrysemys_picta_bellii	ENSCPBP00000037011	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	94.4325	94.0043	sphenodon_punctatus	ENSSPUP00000018974	99.7738	99.3213
ENSG00000175387	homo_sapiens	ENSP00000262160	24.4111	23.7687	sphenodon_punctatus	ENSSPUP00000012142	97.4359	94.8718
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	crocodylus_porosus	ENSCPRP00005021221	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	92.0771	91.2206	laticauda_laticaudata	ENSLLTP00000019630	99.537	98.6111
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	pseudonaja_textilis	ENSPTXP00000009152	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	anas_platyrhynchos_platyrhynchos	ENSAPLP00000004542	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	98.7152	gallus_gallus	ENSGALP00010018041	99.7859	98.7152
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.3576	gallus_gallus	ENSGALP00010014319	97.6939	97.2746
ENSG00000175387	homo_sapiens	ENSP00000262160	82.6552	81.3705	meleagris_gallopavo	ENSMGAP00000022586	98.4694	96.9388
ENSG00000175387	homo_sapiens	ENSP00000262160	98.9293	98.2869	serinus_canaria	ENSSCAP00000022641	99.1416	98.4979
ENSG00000175387	homo_sapiens	ENSP00000262160	99.3576	98.2869	serinus_canaria	ENSSCAP00000022044	99.3576	98.2869
ENSG00000175387	homo_sapiens	ENSP00000262160	97.4304	96.788	parus_major	ENSPMJP00000003426	96.3983	95.7627
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.1435	anolis_carolinensis	ENSACAP00000017731	100	99.1435
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	99.1435	naja_naja	ENSNNAP00000021922	99.7859	99.1435
ENSG00000175387	homo_sapiens	ENSP00000262160	99.5717	99.1435	podarcis_muralis	ENSPMRP00000014181	99.5717	99.1435
ENSG00000175387	homo_sapiens	ENSP00000262160	92.2912	91.0064	geospiza_fortis	ENSGFOP00000008816	98.1777	96.8109
ENSG00000175387	homo_sapiens	ENSP00000262160	99.1435	98.5011	geospiza_fortis	ENSGFOP00000019341	99.3562	98.7124
ENSG00000175387	homo_sapiens	ENSP00000262160	99.1435	98.5011	taeniopygia_guttata	ENSTGUP00000000024	95.0719	94.4558
ENSG00000175387	homo_sapiens	ENSP00000262160	98.9293	97.0021	erpetoichthys_calabaricus	ENSECRP00000011924	98.9293	97.0021
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	salvator_merianae	ENSSMRP00000021308	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	pelodiscus_sinensis	ENSPSIP00000007362	94.1532	93.75
ENSG00000175387	homo_sapiens	ENSP00000262160	89.2934	88.4368	gopherus_evgoodei	ENSGEVP00005028259	99.0499	98.0998
ENSG00000175387	homo_sapiens	ENSP00000262160	99.7859	98.7152	chelonoidis_abingdonii	ENSCABP00000028136	99.7859	98.7152
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	struthio_camelus_australis	ENSSCUP00000002102	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	47.9657	47.7516	anser_brachyrhynchus	ENSABRP00000013037	98.6784	98.2379
ENSG00000175387	homo_sapiens	ENSP00000262160	99.3576	98.9293	strigops_habroptila	ENSSHBP00005001199	99.3576	98.9293
ENSG00000175387	homo_sapiens	ENSP00000262160	99.3576	98.5011	strigops_habroptila	ENSSHBP00005012470	99.3576	98.5011
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	terrapene_carolina_triunguis	ENSTMTP00000001819	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	75.803	66.167	ciona_savignyi	ENSCSAVP00000007961	78.6667	68.6667
ENSG00000175387	homo_sapiens	ENSP00000262160	67.666	55.0321	ciona_savignyi	ENSCSAVP00000008093	63.2	51.4
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	aquila_chrysaetos_chrysaetos	ENSACCP00020024083	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	99.3576	98.7152	ficedula_albicollis	ENSFALP00000009323	99.5708	98.927
ENSG00000175387	homo_sapiens	ENSP00000262160	100	99.5717	coturnix_japonica	ENSCJPP00005005098	100	99.5717
ENSG00000175387	homo_sapiens	ENSP00000262160	87.7944	85.8672	leptobrachium_leishanense	ENSLLEP00000006776	80.5501	78.7819

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000785	part_of chromatin	2	IDA,ISA	Homo_sapiens(9606)	Component
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	2	IBA,ISA	Homo_sapiens(9606)	Function
GO:0000987	enables cis-regulatory region sequence-specific DNA binding	1	IC	Homo_sapiens(9606)	Function
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	2	IDA,ISS	Homo_sapiens(9606)	Function
GO:0001657	involved_in ureteric bud development	1	IEA	Homo_sapiens(9606)	Process
GO:0001701	involved_in in utero embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0001706	involved_in endoderm formation	1	IEA	Homo_sapiens(9606)	Process
GO:0001707	involved_in mesoderm formation	1	ISS	Homo_sapiens(9606)	Process
GO:0003180	involved_in aortic valve morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0003184	involved_in pulmonary valve morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0003203	involved_in endocardial cushion morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0003677	contributes_to DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003682	enables chromatin binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003690	enables double-stranded DNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0003700	contributes_to DNA-binding transcription factor activity	2	IDA	Homo_sapiens(9606)	Function
GO:0005160	enables transforming growth factor beta receptor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005667	part_of transcription regulator complex	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006351	involved_in DNA-templated transcription	1	NAS	Homo_sapiens(9606)	Process
GO:0007179	involved_in transforming growth factor beta receptor signaling pathway	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0007182	acts_upstream_of_or_within common-partner SMAD protein phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0007352	involved_in zygotic specification of dorsal/ventral axis	1	IMP	Homo_sapiens(9606)	Process
GO:0007369	involved_in gastrulation	1	TAS	Homo_sapiens(9606)	Process
GO:0008285	involved_in negative regulation of cell population proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0009653	involved_in anatomical structure morphogenesis	1	IBA	Homo_sapiens(9606)	Process
GO:0009749	involved_in response to glucose	1	IEA	Homo_sapiens(9606)	Process
GO:0009791	involved_in post-embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0009952	involved_in anterior/posterior pattern specification	1	ISS	Homo_sapiens(9606)	Process
GO:0010628	involved_in positive regulation of gene expression	1	IEA	Homo_sapiens(9606)	Process
GO:0010718	involved_in positive regulation of epithelial to mesenchymal transition	1	ISS	Homo_sapiens(9606)	Process
GO:0017015	involved_in regulation of transforming growth factor beta receptor signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0019902	enables phosphatase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0023019	involved_in signal transduction involved in regulation of gene expression	1	IEA	Homo_sapiens(9606)	Process
GO:0030073	involved_in insulin secretion	1	IEA	Homo_sapiens(9606)	Process
GO:0030154	involved_in cell differentiation	1	IBA	Homo_sapiens(9606)	Process
GO:0030324	involved_in lung development	1	IEA	Homo_sapiens(9606)	Process
GO:0030325	involved_in adrenal gland development	1	IEA	Homo_sapiens(9606)	Process
GO:0030513	involved_in positive regulation of BMP signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0031016	involved_in pancreas development	1	IEA	Homo_sapiens(9606)	Process
GO:0031053	involved_in primary miRNA processing	1	TAS	Homo_sapiens(9606)	Process
GO:0031625	enables ubiquitin protein ligase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0032444	part_of activin responsive factor complex	1	IDA	Homo_sapiens(9606)	Component
GO:0032924	involved_in activin receptor signaling pathway	3	IBA,IMP,NAS	Homo_sapiens(9606)	Process
GO:0032991	part_of protein-containing complex	1	IMP	Homo_sapiens(9606)	Component
GO:0034713	enables type I transforming growth factor beta receptor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0035265	involved_in organ growth	1	IEA	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	1	ISS	Homo_sapiens(9606)	Process
GO:0038092	involved_in nodal signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IEA	Homo_sapiens(9606)	Function
GO:0045165	involved_in cell fate commitment	1	ISS	Homo_sapiens(9606)	Process
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IMP	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	3	IDA,IMP,ISS	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	3	IBA,IDA,ISS	Homo_sapiens(9606)	Process
GO:0046332	enables SMAD binding	1	IPI	Homo_sapiens(9606)	Function
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0048156	enables tau protein binding	1	ISS	Homo_sapiens(9606)	Function
GO:0048340	involved_in paraxial mesoderm morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0048617	involved_in embryonic foregut morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0048701	involved_in embryonic cranial skeleton morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0051098	involved_in regulation of binding	1	ISS	Homo_sapiens(9606)	Process
GO:0060039	involved_in pericardium development	1	IEA	Homo_sapiens(9606)	Process
GO:0060395	involved_in SMAD protein signal transduction	1	IBA	Homo_sapiens(9606)	Process
GO:0061629	enables RNA polymerase II-specific DNA-binding transcription factor binding	1	IEA	Homo_sapiens(9606)	Function
GO:0062009	involved_in secondary palate development	1	ISS	Homo_sapiens(9606)	Process
GO:0070410	enables co-SMAD binding	1	IPI	Homo_sapiens(9606)	Function
GO:0070411	enables I-SMAD binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0070412	enables R-SMAD binding	1	IPI	Homo_sapiens(9606)	Function
GO:0070723	involved_in response to cholesterol	1	IDA	Homo_sapiens(9606)	Process
GO:0071141	part_of SMAD protein complex	1	IDA	Homo_sapiens(9606)	Component
GO:0071142	part_of homomeric SMAD protein complex	1	IPI	Homo_sapiens(9606)	Component
GO:0071144	part_of heteromeric SMAD protein complex	3	IBA,IDA,IPI	Homo_sapiens(9606)	Component
GO:0097718	enables disordered domain specific binding	1	IPI	Homo_sapiens(9606)	Function
GO:0140297	enables DNA-binding transcription factor binding	1	IPI	Homo_sapiens(9606)	Function
GO:1900224	involved_in positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	1	IMP	Homo_sapiens(9606)	Process