RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000174840	Gene ID	201626	Accession	25386
Symbol	PDE12	Alias	2-PDE;2'-PDE	Full Name	phosphodiesterase 12
Status	Confidence	Length	10575 bases	Strand	Plus strand
Position	3 : 57556274 - 57566848	RNA binding domain	Exo_endo_phos
Summary	Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000309142	Exo_endo_phos	PF03372	2.1e-19	1
ENSP00000420626	Exo_endo_phos	PF03372	4.2e-08	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
35682820	How RNases Shape Mitochondrial Transcriptomes.	Jérémy Cartalas	2022-05-30	International journal of molecular sciences

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
PDE12-201	ENST00000311180	8780	609aa	ENSP00000309142
PDE12-202	ENST00000487257	3040	472aa	ENSP00000420626

Gene Model

Click here to download ENSG00000174840's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000174840's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000175	enables 3-5-RNA exonuclease activity	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0000288	involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0000958	involved_in mitochondrial mRNA catabolic process	1	IMP	Homo_sapiens(9606)	Process
GO:0004527	enables exonuclease activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004535	enables poly(A)-specific ribonuclease activity	1	IMP	Homo_sapiens(9606)	Function
GO:0005739	is_active_in mitochondrion	1	IBA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	2	IDA,IMP	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006397	involved_in mRNA processing	1	IEA	Homo_sapiens(9606)	Process
GO:0034611	enables oligoribonucleotidase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0035457	involved_in cellular response to interferon-alpha	1	IMP	Homo_sapiens(9606)	Process
GO:0044528	involved_in regulation of mitochondrial mRNA stability	1	IMP	Homo_sapiens(9606)	Process
GO:0045070	involved_in positive regulation of viral genome replication	1	IMP	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0051607	involved_in defense response to virus	1	TAS	Homo_sapiens(9606)	Process
GO:0071346	involved_in cellular response to type II interferon	1	IDA	Homo_sapiens(9606)	Process
GO:0071359	involved_in cellular response to dsRNA	1	IDA	Homo_sapiens(9606)	Process
GO:0090305	involved_in nucleic acid phosphodiester bond hydrolysis	1	IDA	Homo_sapiens(9606)	Process
GO:0140374	involved_in antiviral innate immune response	1	IDA	Homo_sapiens(9606)	Process

Expression