RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-OC43FlavivirusesHIVSARS-COV-2SINVDengueZika
Drug	N.A.
Main interacting RNAs	ncRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000174780	Gene ID	6731	Accession	11303
Symbol	SRP72	Alias	BMFF;BMFS1;HEL103	Full Name	signal recognition particle 72
Status	Confidence	Length	36065 bases	Strand	Plus strand
Position	4 : 56467617 - 56503681	RNA binding domain	SRP72
Summary	This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]