RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000174606	Gene ID	90806	Accession	30534
Symbol	ANGEL2	Alias	Ccr4d;KIAA0759L	Full Name	angel homolog 2
Status	Confidence	Length	23686 bases	Strand	Minus strand
Position	1 : 212992182 - 213015867	RNA binding domain	ANGEL2_N , Exo_endo_phos
Summary	Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Located in Cajal body and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000353696	Exo_endo_phos	PF03372	5.2e-27	1
ENSP00000438141	Exo_endo_phos	PF03372	5.2e-27	1
ENSP00000355929	Exo_endo_phos	PF03372	1.4e-26	1
ENSP00000355929	ANGEL2_N	PF19339	1.6e-60	2
ENSP00000355929	ANGEL2_N	PF19339	1.6e-60	3

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
36180430	ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing.	Paula Clemente	2022-09-30	Nature communications
30777893	Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues.	Basak Eraslan	2019-02-18	Molecular systems biology
35156311	Recent insights into the structure, function, and regulation of the eukaryotic transfer RNA splicing endonuclease complex.	K Cassandra Hayne	2022-09-01	Wiley interdisciplinary reviews. RNA

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
ANGEL2-202	ENST00000366962	4690	544aa	ENSP00000355929
ANGEL2-201	ENST00000360506	4323	375aa	ENSP00000353696
ANGEL2-204	ENST00000473303	2135	No protein	-
ANGEL2-207	ENST00000498650	364	No protein	-
ANGEL2-205	ENST00000476904	913	No protein	-
ANGEL2-203	ENST00000460337	1243	No protein	-
ANGEL2-206	ENST00000481918	851	No protein	-
ANGEL2-208	ENST00000535388	2517	375aa	ENSP00000438141

Gene Model

Click here to download ENSG00000174606's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000174606's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000175	enables 3-5-RNA exonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0003730	enables mRNA 3-UTR binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0015030	located_in Cajal body	1	IDA	Homo_sapiens(9606)	Component
GO:0045930	involved_in negative regulation of mitotic cell cycle	1	IMP	Homo_sapiens(9606)	Process
GO:0070935	involved_in 3-UTR-mediated mRNA stabilization	2	IBA,IMP	Homo_sapiens(9606)	Process

Expression