Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000174405 Gene ID 3981 Accession 6601
Symbol LIG4 Alias LIG4S Full Name DNA ligase 4
Status Confidence Length 10930 bases Strand Minus strand
Position 13 : 108207439 - 108218368 RNA binding domain RNA_ligase
Summary The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000480814 RNA_ligase PF09414 6e-10 1
ENSP00000508867 RNA_ligase PF09414 6e-10 1
ENSP00000509468 RNA_ligase PF09414 6e-10 1
ENSP00000385955 RNA_ligase PF09414 6.6e-10 1
ENSP00000402030 RNA_ligase PF09414 6.6e-10 1
ENSP00000484288 RNA_ligase PF09414 6.6e-10 1
ENSP00000508512 RNA_ligase PF09414 6.6e-10 1
ENSP00000509122 RNA_ligase PF09414 6.6e-10 1
ENSP00000509226 RNA_ligase PF09414 6.6e-10 1
ENSP00000509299 RNA_ligase PF09414 6.6e-10 1
ENSP00000509304 RNA_ligase PF09414 6.6e-10 1
ENSP00000509344 RNA_ligase PF09414 6.6e-10 1
ENSP00000509502 RNA_ligase PF09414 6.6e-10 1
ENSP00000509564 RNA_ligase PF09414 6.6e-10 1
ENSP00000509685 RNA_ligase PF09414 6.6e-10 1
ENSP00000509906 RNA_ligase PF09414 6.6e-10 1
ENSP00000509942 RNA_ligase PF09414 6.6e-10 1
ENSP00000510014 RNA_ligase PF09414 6.6e-10 1
ENSP00000510567 RNA_ligase PF09414 6.6e-10 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
LIG4-203 ENST00000611712 4180 911aa ENSP00000484288
LIG4-201 ENST00000405925 4065 911aa ENSP00000385955
LIG4-202 ENST00000442234 3981 911aa ENSP00000402030
LIG4-216 ENST00000689762 4027 844aa ENSP00000508867
LIG4-204 ENST00000614526 3924 844aa ENSP00000480814
LIG4-218 ENST00000692222 6758 911aa ENSP00000509226
LIG4-213 ENST00000688455 4348 911aa ENSP00000509304
LIG4-206 ENST00000686095 4043 911aa ENSP00000509942
LIG4-208 ENST00000686913 4149 911aa ENSP00000509299
LIG4-214 ENST00000688529 4094 911aa ENSP00000509906
LIG4-210 ENST00000687164 3994 911aa ENSP00000508512
LIG4-211 ENST00000687822 5799 911aa ENSP00000509344
LIG4-212 ENST00000688396 4416 911aa ENSP00000509564
LIG4-215 ENST00000688595 4346 911aa ENSP00000509502
LIG4-205 ENST00000685338 3987 911aa ENSP00000510567
LIG4-209 ENST00000686926 3443 911aa ENSP00000509122
LIG4-207 ENST00000686204 6142 911aa ENSP00000509685
LIG4-217 ENST00000690127 3085 844aa ENSP00000509468
LIG4-219 ENST00000693040 2853 911aa ENSP00000510014

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
5829Carotid Artery Diseases7.51545154846385E-617903303
6984Urinalysis2.03163196377317E-617903293

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000174405homo_sapiensENSP0000036778730.327116.9475homo_sapiensENSP0000040203033.589518.7706
ENSG00000174405homo_sapiensENSP0000026327430.359117.0838homo_sapiensENSP0000040203030.625717.2338

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000174405homo_sapiensENSP0000040203099.121897.5851nomascus_leucogenysENSNLEP0000000961599.121897.5851
ENSG00000174405homo_sapiensENSP0000040203099.780599.3414pan_paniscusENSPPAP0000001957399.780599.3414
ENSG00000174405homo_sapiensENSP0000040203098.682897.8046pongo_abeliiENSPPYP0000000631498.791297.9121
ENSG00000174405homo_sapiensENSP0000040203099.780599.4511pan_troglodytesENSPTRP0000004275799.780599.4511
ENSG00000174405homo_sapiensENSP0000040203099.890299.6707gorilla_gorillaENSGGOP0000002230399.890299.6707
ENSG00000174405homo_sapiensENSP0000040203086.278874.753ornithorhynchus_anatinusENSOANP0000004334986.563975
ENSG00000174405homo_sapiensENSP0000040203091.328282.9857sarcophilus_harrisiiENSSHAP0000002956191.328282.9857
ENSG00000174405homo_sapiensENSP0000040203094.840890.2305dasypus_novemcinctusENSDNOP0000002712094.736890.1316
ENSG00000174405homo_sapiensENSP0000040203090.669683.9737echinops_telfairiENSETEP0000001261891.574384.8115
ENSG00000174405homo_sapiensENSP0000040203097.804695.1701callithrix_jacchusENSCJAP0000004862597.804695.1701
ENSG00000174405homo_sapiensENSP0000040203098.463297.0362cercocebus_atysENSCATP0000000688898.463297.0362
ENSG00000174405homo_sapiensENSP0000040203097.14695.6092macaca_fascicularisENSMFAP0000000187991.520290.0724
ENSG00000174405homo_sapiensENSP0000040203098.57397.146macaca_mulattaENSMMUP0000006886898.57397.146
ENSG00000174405homo_sapiensENSP0000040203098.57397.2558macaca_nemestrinaENSMNEP0000000516498.57397.2558
ENSG00000174405homo_sapiensENSP0000040203098.463297.146papio_anubisENSPANP0000000684298.463297.146
ENSG00000174405homo_sapiensENSP0000040203098.353596.9265mandrillus_leucophaeusENSMLEP0000000645198.353596.9265
ENSG00000174405homo_sapiensENSP0000040203094.950689.5719tursiops_truncatusENSTTRP0000001200594.950689.5719
ENSG00000174405homo_sapiensENSP0000040203092.425987.0472mus_spretusMGP_SPRETEiJ_P008713792.425987.0472
ENSG00000174405homo_sapiensENSP0000040203095.389791.3282equus_asinusENSEASP0000505374995.389791.3282
ENSG00000174405homo_sapiensENSP0000040203094.29288.9133capra_hircusENSCHIP0000000086794.29288.9133
ENSG00000174405homo_sapiensENSP0000040203094.401888.1449loxodonta_africanaENSLAFP0000002417394.19587.9518
ENSG00000174405homo_sapiensENSP0000040203095.828890.3403panthera_leoENSPLOP0000000590495.828890.3403
ENSG00000174405homo_sapiensENSP0000040203094.511589.3524ailuropoda_melanoleucaENSAMEP0000002073988.217283.4016
ENSG00000174405homo_sapiensENSP0000040203095.060489.2426bos_indicus_hybridENSBIXP0000504117295.060489.2426
ENSG00000174405homo_sapiensENSP0000040203095.389791.438oryctolagus_cuniculusENSOCUP0000001351695.389791.438
ENSG00000174405homo_sapiensENSP0000040203095.060490.8891equus_caballusENSECAP0000007450095.060490.8891
ENSG00000174405homo_sapiensENSP0000040203095.499590.9989canis_lupus_familiarisENSCAFP0084503903095.499590.9989
ENSG00000174405homo_sapiensENSP0000040203095.828890.3403panthera_pardusENSPPRP0000002681395.828890.3403
ENSG00000174405homo_sapiensENSP0000040203095.170190.5598marmota_marmota_marmotaENSMMMP0000002305595.170190.5598
ENSG00000174405homo_sapiensENSP0000040203095.389790.8891balaenoptera_musculusENSBMSP0001002400495.389790.8891
ENSG00000174405homo_sapiensENSP0000040203093.962788.3644cavia_porcellusENSCPOP0000001285393.962788.3644
ENSG00000174405homo_sapiensENSP0000040203095.609290.1207felis_catusENSFCAP0000002370595.609290.1207
ENSG00000174405homo_sapiensENSP0000040203094.731189.2426ursus_americanusENSUAMP0000000411094.731189.2426
ENSG00000174405homo_sapiensENSP0000040203092.206484.5225monodelphis_domesticaENSMODP0000003673892.206484.5225
ENSG00000174405homo_sapiensENSP0000040203095.060489.1328bison_bison_bisonENSBBBP0000001121695.060489.1328
ENSG00000174405homo_sapiensENSP0000040203085.7380.6806monodon_monocerosENSMMNP0001502569594.781689.199
ENSG00000174405homo_sapiensENSP0000040203094.401888.8035sus_scrofaENSSSCP0000001018694.505588.9011
ENSG00000174405homo_sapiensENSP0000040203094.182287.7058octodon_degusENSODEP0000002628394.182287.7058
ENSG00000174405homo_sapiensENSP0000040203094.511587.8156jaculus_jaculusENSJJAP0000000343994.511587.8156
ENSG00000174405homo_sapiensENSP0000040203085.620279.4731ovis_aries_rambouilletENSOARP0002000418094.202987.4396
ENSG00000174405homo_sapiensENSP0000040203093.962788.4742ochotona_princepsENSOPRP0000000527793.962788.4742
ENSG00000174405homo_sapiensENSP0000040203095.279989.9012delphinapterus_leucasENSDLEP0000002710795.279989.9012
ENSG00000174405homo_sapiensENSP0000040203094.731189.9012physeter_catodonENSPCTP0000502588694.731189.9012
ENSG00000174405homo_sapiensENSP0000040203092.86587.2667mus_caroliMGP_CAROLIEiJ_P008372492.86587.2667
ENSG00000174405homo_sapiensENSP0000040203092.645487.0472mus_musculusENSMUSP0000009313092.645487.0472
ENSG00000174405homo_sapiensENSP0000040203094.511588.9133dipodomys_ordiiENSDORP0000001663594.511588.9133
ENSG00000174405homo_sapiensENSP0000040203094.29289.023mustela_putorius_furoENSMPUP0000001855694.29289.023
ENSG00000174405homo_sapiensENSP0000040203098.133996.1581aotus_nancymaaeENSANAP0000000141298.133996.1581
ENSG00000174405homo_sapiensENSP0000040203097.804695.0604saimiri_boliviensis_boliviensisENSSBOP0000000475997.804695.0604
ENSG00000174405homo_sapiensENSP0000040203061.9158.0681vicugna_pacosENSVPAP0000000209961.9158.0681
ENSG00000174405homo_sapiensENSP0000040203098.463297.146chlorocebus_sabaeusENSCSAP0000001778498.463297.146
ENSG00000174405homo_sapiensENSP0000040203095.828891.438tupaia_belangeriENSTBEP0000001543195.828891.438
ENSG00000174405homo_sapiensENSP0000040203083.534676.18mesocricetus_auratusENSMAUP0000002104089.740681.8396
ENSG00000174405homo_sapiensENSP0000040203094.731189.3524phocoena_sinusENSPSNP0000002106494.731189.3524
ENSG00000174405homo_sapiensENSP0000040203094.950690.011camelus_dromedariusENSCDRP0000500577394.950690.011
ENSG00000174405homo_sapiensENSP0000040203095.71990.2305panthera_tigris_altaicaENSPTIP0000000878095.71990.2305
ENSG00000174405homo_sapiensENSP0000040203092.096686.169rattus_norvegicusENSRNOP0000007825092.096686.169
ENSG00000174405homo_sapiensENSP0000040203096.487493.7431prolemur_simusENSPSMP0000002319396.487493.7431
ENSG00000174405homo_sapiensENSP0000040203091.877184.6323microtus_ochrogasterENSMOCP0000002174391.877184.6323
ENSG00000174405homo_sapiensENSP0000040203093.084583.8639sorex_araneusENSSARP0000000594392.77983.5886
ENSG00000174405homo_sapiensENSP0000040203092.86587.0472peromyscus_maniculatus_bairdiiENSPEMP0000000009292.763286.9518
ENSG00000174405homo_sapiensENSP0000040203094.840889.1328bos_mutusENSBMUP0000002761394.840889.1328
ENSG00000174405homo_sapiensENSP0000040203092.86587.3765mus_spicilegusENSMSIP0000001168692.86587.3765
ENSG00000174405homo_sapiensENSP0000040203092.974886.9374cricetulus_griseus_chok1gshdENSCGRP0000101009592.872886.8421
ENSG00000174405homo_sapiensENSP0000040203095.499590.8891pteropus_vampyrusENSPVAP0000001547895.499590.8891
ENSG00000174405homo_sapiensENSP0000040203095.71991.1087myotis_lucifugusENSMLUP0000001796495.71991.1087
ENSG00000174405homo_sapiensENSP0000040203092.425984.4127vombatus_ursinusENSVURP0001002936992.425984.4127
ENSG00000174405homo_sapiensENSP0000040203092.425984.4127vombatus_ursinusENSVURP0001000570292.425984.4127
ENSG00000174405homo_sapiensENSP0000040203094.840891.1087rhinolophus_ferrumequinumENSRFEP0001001154294.840891.1087
ENSG00000174405homo_sapiensENSP0000040203094.29288.2547neovison_visonENSNVIP0000000348294.29288.2547
ENSG00000174405homo_sapiensENSP0000040203095.060489.2426bos_taurusENSBTAP0000002109295.060489.2426
ENSG00000174405homo_sapiensENSP0000040203050.384247.64heterocephalus_glaber_femaleENSHGLP0000004631197.245891.9492
ENSG00000174405homo_sapiensENSP0000040203078.375472.4479heterocephalus_glaber_femaleENSHGLP0000000086993.57886.5007
ENSG00000174405homo_sapiensENSP0000040203097.14695.6092rhinopithecus_bietiENSRBIP0000003231898.224296.6704
ENSG00000174405homo_sapiensENSP0000040203095.499590.9989canis_lupus_dingoENSCAFP0002002705195.499590.9989
ENSG00000174405homo_sapiensENSP0000040203095.170190.3403sciurus_vulgarisENSSVLP0000500528495.170190.3403
ENSG00000174405homo_sapiensENSP0000040203092.206484.303phascolarctos_cinereusENSPCIP0000002940592.206484.303
ENSG00000174405homo_sapiensENSP0000040203094.511587.2667nannospalax_galiliENSNGAP0000001097594.511587.2667
ENSG00000174405homo_sapiensENSP0000040203094.840889.1328bos_grunniensENSBGRP0000000689494.840889.1328
ENSG00000174405homo_sapiensENSP0000040203094.840889.6817chinchilla_lanigeraENSCLAP0000000475394.840889.6817
ENSG00000174405homo_sapiensENSP0000040203095.060489.1328cervus_hanglu_yarkandensisENSCHYP0000003963095.060489.1328
ENSG00000174405homo_sapiensENSP0000040203094.401888.9133catagonus_wagneriENSCWAP0000000874394.505589.011
ENSG00000174405homo_sapiensENSP0000040203095.170190.4501ictidomys_tridecemlineatusENSSTOP0000002330895.170190.4501
ENSG00000174405homo_sapiensENSP0000040203096.926591.9868otolemur_garnettiiENSOGAP0000001630896.502791.5847
ENSG00000174405homo_sapiensENSP0000040203098.243795.4995cebus_imitatorENSCCAP0000000475798.243795.4995
ENSG00000174405homo_sapiensENSP0000040203095.170190.2305urocitellus_parryiiENSUPAP0001001403295.170190.2305
ENSG00000174405homo_sapiensENSP0000040203094.182288.3644moschus_moschiferusENSMMSP0000000995194.493488.6564
ENSG00000174405homo_sapiensENSP0000040203098.353596.5971rhinopithecus_roxellanaENSRROP0000000148698.353596.5971
ENSG00000174405homo_sapiensENSP0000040203092.974887.0472mus_pahariMGP_PahariEiJ_P004657992.974887.0472
ENSG00000174405homo_sapiensENSP0000040203032.491817.124caenorhabditis_elegansC07H6.1.139.94621.0526
ENSG00000174405homo_sapiensENSP0000040203046.322727.5521drosophila_melanogasterFBpp007367845.969527.342
ENSG00000174405homo_sapiensENSP0000040203046.432531.5038ciona_intestinalisENSCINP0000001941064.580243.8168
ENSG00000174405homo_sapiensENSP0000040203047.530236.5532petromyzon_marinusENSPMAP0000000509367.974952.2763
ENSG00000174405homo_sapiensENSP0000040203064.983545.1153eptatretus_burgeriENSEBUP0000002311960.408241.9388
ENSG00000174405homo_sapiensENSP0000040203082.656469.045callorhinchus_miliiENSCMIP0000001001582.385168.8184
ENSG00000174405homo_sapiensENSP0000040203084.193272.2283latimeria_chalumnaeENSLACP0000000368884.193272.2283
ENSG00000174405homo_sapiensENSP0000040203082.327170.2525lepisosteus_oculatusENSLOCP0000001083681.168869.2641
ENSG00000174405homo_sapiensENSP0000040203077.60762.7881clupea_harengusENSCHAP0000005155177.692362.8571
ENSG00000174405homo_sapiensENSP0000040203078.594963.5565danio_rerioENSDARP0000008008378.767963.6964
ENSG00000174405homo_sapiensENSP0000040203079.143863.7761carassius_auratusENSCARP0000006561678.454863.2209
ENSG00000174405homo_sapiensENSP0000040203079.582964.764astyanax_mexicanusENSAMXP0000000841375.051861.0766
ENSG00000174405homo_sapiensENSP0000040203080.570864.5445ictalurus_punctatusENSIPUP0000002024880.748164.6865
ENSG00000174405homo_sapiensENSP0000040203081.119766.8496esox_luciusENSELUP0000002976880.853466.6302
ENSG00000174405homo_sapiensENSP0000040203080.02263.8858electrophorus_electricusENSEEEP0000002466880.19864.0264
ENSG00000174405homo_sapiensENSP0000040203080.241566.0812oncorhynchus_mykissENSOMYP0000002995580.153566.0088
ENSG00000174405homo_sapiensENSP0000040203010.31838.67179salmo_salarENSSSAP0000003077465.277854.8611
ENSG00000174405homo_sapiensENSP0000040203080.131766.0812salmo_salarENSSSAP0000016871879.868765.8643
ENSG00000174405homo_sapiensENSP0000040203080.241566.3008salmo_truttaENSSTUP0000011038379.978166.0832
ENSG00000174405homo_sapiensENSP0000040203077.497360.5928gadus_morhuaENSGMOP0000001374675.832459.2911
ENSG00000174405homo_sapiensENSP0000040203079.692664.6542fundulus_heteroclitusENSFHEP0000000636072.16758.5487
ENSG00000174405homo_sapiensENSP0000040203080.46164.6542poecilia_reticulataENSPREP0000001070580.726964.8678
ENSG00000174405homo_sapiensENSP0000040203080.02264.4347xiphophorus_maculatusENSXMAP0000001517180.19864.5765
ENSG00000174405homo_sapiensENSP0000040203080.46164.4347oryzias_latipesENSORLP0000003733080.372864.364
ENSG00000174405homo_sapiensENSP0000040203078.814564.2151cyclopterus_lumpusENSCLMP0000500594978.901164.2857
ENSG00000174405homo_sapiensENSP0000040203080.131765.2031oreochromis_niloticusENSONIP0000001506980.219865.2747
ENSG00000174405homo_sapiensENSP0000040203079.912265.0933haplochromis_burtoniENSHBUP000000049128065.1648
ENSG00000174405homo_sapiensENSP0000040203080.02265.3128astatotilapia_callipteraENSACLP0000004014280.109965.3846
ENSG00000174405homo_sapiensENSP0000040203079.912264.6542sparus_aurataENSSAUP0001000977276.631662
ENSG00000174405homo_sapiensENSP0000040203079.692665.8617lates_calcariferENSLCAP0001003167079.08565.3595
ENSG00000174405homo_sapiensENSP0000040203084.522572.7772xenopus_tropicalisENSXETP0000011325484.522572.7772
ENSG00000174405homo_sapiensENSP0000040203088.803579.2536chrysemys_picta_belliiENSCPBP0000003329188.51278.9934
ENSG00000174405homo_sapiensENSP0000040203081.44971.899sphenodon_punctatusENSSPUP0000000314388.333377.9762
ENSG00000174405homo_sapiensENSP0000040203087.59676.9484crocodylus_porosusENSCPRP0000502401487.308576.6958
ENSG00000174405homo_sapiensENSP0000040203084.632372.8869laticauda_laticaudataENSLLTP0000000960683.351371.7838
ENSG00000174405homo_sapiensENSP0000040203084.522572.7772notechis_scutatusENSNSUP0000000040785.555673.6667
ENSG00000174405homo_sapiensENSP0000040203084.412772.6674pseudonaja_textilisENSPTXP0000000341584.78572.9879
ENSG00000174405homo_sapiensENSP0000040203086.059375.1921anas_platyrhynchos_platyrhynchosENSAPLP0000000109586.248675.3575
ENSG00000174405homo_sapiensENSP0000040203086.608175.6312gallus_gallusENSGALP0001002091186.513275.5482
ENSG00000174405homo_sapiensENSP0000040203086.498475.7409meleagris_gallopavoENSMGAP0000001647486.403575.6579
ENSG00000174405homo_sapiensENSP0000040203085.839775.0823serinus_canariaENSSCAP0000002264885.745675
ENSG00000174405homo_sapiensENSP0000040203085.7374.9726parus_majorENSPMJP0000000087071.783162.7757
ENSG00000174405homo_sapiensENSP0000040203086.608175.8507anolis_carolinensisENSACAP0000001427586.608175.8507
ENSG00000174405homo_sapiensENSP0000040203080.131765.6422neolamprologus_brichardiENSNBRP0000002787280.219865.7143
ENSG00000174405homo_sapiensENSP0000040203084.632373.2162naja_najaENSNNAP0000001394383.261372.0302
ENSG00000174405homo_sapiensENSP0000040203053.896847.3106podarcis_muralisENSPMRP0000000360784.655274.3103
ENSG00000174405homo_sapiensENSP0000040203085.620274.5335geospiza_fortisENSGFOP0000000052585.526374.4518
ENSG00000174405homo_sapiensENSP0000040203085.7374.8628taeniopygia_guttataENSTGUP0000001112485.7374.8628
ENSG00000174405homo_sapiensENSP0000040203079.582964.764kryptolebias_marmoratusENSKMAP0000000146978.633463.9913
ENSG00000174405homo_sapiensENSP0000040203084.961672.8869salvator_merianaeENSSMRP0000002733584.868472.807
ENSG00000174405homo_sapiensENSP0000040203080.570865.8617oryzias_javanicusENSOJAP0000000059580.659365.9341
ENSG00000174405homo_sapiensENSP0000040203080.46166.3008amphilophus_citrinellusENSACIP0000002356180.549566.3736
ENSG00000174405homo_sapiensENSP0000040203079.802465.8617dicentrarchus_labraxENSDLAP0000505004779.890165.9341
ENSG00000174405homo_sapiensENSP0000040203081.009965.6422amphiprion_perculaENSAPEP0000002504881.277565.859
ENSG00000174405homo_sapiensENSP0000040203080.02264.8738oryzias_sinensisENSOSIP0000003252779.934264.8026
ENSG00000174405homo_sapiensENSP0000040203088.693779.034pelodiscus_sinensisENSPSIP0000000150088.596578.9474
ENSG00000174405homo_sapiensENSP0000040203046.103240.5049gopherus_evgoodeiENSGEVP0000502098179.847970.1521
ENSG00000174405homo_sapiensENSP0000040203088.693779.1438gopherus_evgoodeiENSGEVP0000501172188.499578.9704
ENSG00000174405homo_sapiensENSP0000040203087.925478.2656chelonoidis_abingdoniiENSCABP0000001606587.732778.0942
ENSG00000174405homo_sapiensENSP0000040203080.790366.5203seriola_dumeriliENSSDUP0000001419980.525266.302
ENSG00000174405homo_sapiensENSP0000040203080.02265.0933cottoperca_gobioENSCGOP0000000065678.471563.8321
ENSG00000174405homo_sapiensENSP0000040203086.388676.18struthio_camelus_australisENSSCUP0000000298386.199376.0131
ENSG00000174405homo_sapiensENSP0000040203085.839774.9726anser_brachyrhynchusENSABRP0000000712179.795969.6939
ENSG00000174405homo_sapiensENSP0000040203078.704762.8979gasterosteus_aculeatusENSGACP0000001865978.791262.967
ENSG00000174405homo_sapiensENSP0000040203078.485264.2151cynoglossus_semilaevisENSCSEP0000002178677.548863.449
ENSG00000174405homo_sapiensENSP0000040203080.46164.8738poecilia_formosaENSPFOP0000000076080.726965.0881
ENSG00000174405homo_sapiensENSP0000040203080.351366.191myripristis_murdjanENSMMDP0000500550980.439666.2637
ENSG00000174405homo_sapiensENSP0000040203079.802465.8617sander_luciopercaENSSLUP0000006065279.802465.8617
ENSG00000174405homo_sapiensENSP0000040203086.388675.8507strigops_habroptilaENSSHBP0000500588386.388675.8507
ENSG00000174405homo_sapiensENSP0000040203081.009965.5324amphiprion_ocellarisENSAOCP0000000787981.277565.7489
ENSG00000174405homo_sapiensENSP0000040203088.474279.1438terrapene_carolina_triunguisENSTMTP0000000022188.474279.1438
ENSG00000174405homo_sapiensENSP0000040203080.900166.9594hucho_huchoENSHHUP0000005906879.162265.5209
ENSG00000174405homo_sapiensENSP0000040203080.241565.9715betta_splendensENSBSLP0000000730579.54365.3972
ENSG00000174405homo_sapiensENSP0000040203080.131764.6542pygocentrus_nattereriENSPNAP0000002107980.66365.0829
ENSG00000174405homo_sapiensENSP0000040203080.131764.6542pygocentrus_nattereriENSPNAP0000003686580.66365.0829
ENSG00000174405homo_sapiensENSP0000040203080.46165.8617anabas_testudineusENSATEP0000000796180.549565.9341
ENSG00000174405homo_sapiensENSP0000040203054.335937.4314ciona_savignyiENSCSAVP0000001754464.285744.2857
ENSG00000174405homo_sapiensENSP0000040203044.566424.2591saccharomyces_cerevisiaeYOR005C43.008523.411
ENSG00000174405homo_sapiensENSP0000040203079.03464.764seriola_lalandi_dorsalisENSSLDP000000040808065.5556
ENSG00000174405homo_sapiensENSP0000040203074.204260.5928labrus_bergyltaENSLBEP0000001895881.741266.7473
ENSG00000174405homo_sapiensENSP0000040203079.912265.2031pundamilia_nyerereiENSPNYP000000127338065.2747
ENSG00000174405homo_sapiensENSP0000040203080.351366.4105mastacembelus_armatusENSMAMP000000124988066.1202
ENSG00000174405homo_sapiensENSP0000040203080.46165.2031stegastes_partitusENSSPAP0000000208880.549565.2747
ENSG00000174405homo_sapiensENSP0000040203080.351366.0812oncorhynchus_tshawytschaENSOTSP0000508497980.087565.8643
ENSG00000174405homo_sapiensENSP0000040203080.351366.0812oncorhynchus_tshawytschaENSOTSP0000504611780.087565.8643
ENSG00000174405homo_sapiensENSP0000040203080.351366.0812oncorhynchus_tshawytschaENSOTSP0000506373080.087565.8643
ENSG00000174405homo_sapiensENSP0000040203080.351366.0812oncorhynchus_tshawytschaENSOTSP0000509983680.087565.8643
ENSG00000174405homo_sapiensENSP0000040203080.351366.0812oncorhynchus_tshawytschaENSOTSP0000504519880.087565.8643
ENSG00000174405homo_sapiensENSP0000040203080.570865.4226acanthochromis_polyacanthusENSAPOP0000000476480.83765.6388
ENSG00000174405homo_sapiensENSP0000040203085.839775.0823aquila_chrysaetos_chrysaetosENSACCP0002001072585.839775.0823
ENSG00000174405homo_sapiensENSP0000040203079.802466.0812nothobranchius_furzeriENSNFUP0001500432279.97866.2266
ENSG00000174405homo_sapiensENSP0000040203080.131765.8617cyprinodon_variegatusENSCVAP0000002406680.396566.0793
ENSG00000174405homo_sapiensENSP0000040203078.814563.2272denticeps_clupeoidesENSDCDP0000003654774.713859.9376
ENSG00000174405homo_sapiensENSP0000040203079.363365.2031larimichthys_croceaENSLCRP0000500799875.786262.2642
ENSG00000174405homo_sapiensENSP0000040203079.143864.6542takifugu_rubripesENSTRUP0000002511979.405364.8678
ENSG00000174405homo_sapiensENSP0000040203077.387567.7278ficedula_albicollisENSFALP0000000438685.766475.0608
ENSG00000174405homo_sapiensENSP0000040203078.704764.2151hippocampus_comesENSHCOP0000002346778.791264.2857
ENSG00000174405homo_sapiensENSP0000040203050.713539.7366cyprinus_carpio_carpioENSCCRP0000017997775.490259.1503
ENSG00000174405homo_sapiensENSP0000040203079.363363.9956cyprinus_carpio_carpioENSCCRP0000000669678.246763.0952
ENSG00000174405homo_sapiensENSP0000040203084.632372.9967coturnix_japonicaENSCJPP0000501973284.446972.8368
ENSG00000174405homo_sapiensENSP0000040203080.351364.764poecilia_latipinnaENSPLAP0000000037980.616764.978
ENSG00000174405homo_sapiensENSP0000040203079.253663.8858sinocyclocheilus_grahamiENSSGRP0000009855479.340763.956
ENSG00000174405homo_sapiensENSP0000040203080.02265.3128maylandia_zebraENSMZEP0000500232980.109965.3846
ENSG00000174405homo_sapiensENSP0000040203079.802464.9835tetraodon_nigroviridisENSTNIP0000001325480.957765.9243
ENSG00000174405homo_sapiensENSP0000040203081.778366.5203paramormyrops_kingsleyaeENSPKIP0000003097380.890365.798
ENSG00000174405homo_sapiensENSP0000040203080.570865.2031scleropages_formosusENSSFOP0001501994980.748165.3465
ENSG00000174405homo_sapiensENSP0000040203083.863970.5818leptobrachium_leishanenseENSLLEP0000000116780.675867.8986
ENSG00000174405homo_sapiensENSP0000040203074.862861.1416scophthalmus_maximusENSSMAP0000001840981.384266.4678
ENSG00000174405homo_sapiensENSP0000040203011.85519.44018oryzias_melastigmaENSOMEP0000000866166.666753.0864
ENSG00000174405homo_sapiensENSP0000040203063.446852.1405oryzias_melastigmaENSOMEP0000002337383.768168.8406

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000012involved_in single strand break repair1IDAHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region1ICHomo_sapiens(9606)Component
GO:0000793located_in condensed chromosome1IDAHomo_sapiens(9606)Component
GO:0001701involved_in in utero embryonic development1ISSHomo_sapiens(9606)Process
GO:0002328involved_in pro-B cell differentiation1ISSHomo_sapiens(9606)Process
GO:0003677enables DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0003909enables DNA ligase activity2IDA,TASHomo_sapiens(9606)Function
GO:0003910enables DNA ligase (ATP) activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IBAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005958part_of DNA-dependent protein kinase-DNA ligase 4 complex3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0006260involved_in DNA replication1IEAHomo_sapiens(9606)Process
GO:0006266involved_in DNA ligation1IDAHomo_sapiens(9606)Process
GO:0006297involved_in nucleotide-excision repair, DNA gap filling2IBA,IDAHomo_sapiens(9606)Process
GO:0006302involved_in double-strand break repair2IDA,ISSHomo_sapiens(9606)Process
GO:0006303involved_in double-strand break repair via nonhomologous end joining5IBA,IDA,IGI,IMP,TASHomo_sapiens(9606)Process
GO:0007049involved_in cell cycle1IEAHomo_sapiens(9606)Process
GO:0007417involved_in central nervous system development1ISSHomo_sapiens(9606)Process
GO:0008283involved_in cell population proliferation1ISSHomo_sapiens(9606)Process
GO:0010165involved_in response to X-ray1IMPHomo_sapiens(9606)Process
GO:0010332involved_in response to gamma radiation1ISSHomo_sapiens(9606)Process
GO:0016874enables ligase activity1IDAHomo_sapiens(9606)Function
GO:0022008involved_in neurogenesis1IEAHomo_sapiens(9606)Process
GO:0032807part_of DNA ligase IV complex2IBA,IMPHomo_sapiens(9606)Component
GO:0033077involved_in T cell differentiation in thymus1ISSHomo_sapiens(9606)Process
GO:0033151involved_in V(D)J recombination1IDAHomo_sapiens(9606)Process
GO:0033152involved_in immunoglobulin V(D)J recombination1IBAHomo_sapiens(9606)Process
GO:0033153involved_in T cell receptor V(D)J recombination1ISSHomo_sapiens(9606)Process
GO:0035019involved_in somatic stem cell population maintenance1ISSHomo_sapiens(9606)Process
GO:0036464located_in cytoplasmic ribonucleoprotein granule1IDAHomo_sapiens(9606)Component
GO:0043524involved_in negative regulation of neuron apoptotic process1ISSHomo_sapiens(9606)Process
GO:0045190involved_in isotype switching1ISSHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0048144involved_in fibroblast proliferation1IEAHomo_sapiens(9606)Process
GO:0048146involved_in positive regulation of fibroblast proliferation1ISSHomo_sapiens(9606)Process
GO:0050769involved_in positive regulation of neurogenesis1ISSHomo_sapiens(9606)Process
GO:0051102involved_in DNA ligation involved in DNA recombination1ISSHomo_sapiens(9606)Process
GO:0051103involved_in DNA ligation involved in DNA repair2IDA,ISSHomo_sapiens(9606)Process
GO:0051276involved_in chromosome organization1ISSHomo_sapiens(9606)Process
GO:0051301involved_in cell division1IEAHomo_sapiens(9606)Process
GO:0051402involved_in neuron apoptotic process1ISSHomo_sapiens(9606)Process
GO:0070419part_of nonhomologous end joining complex1IDAHomo_sapiens(9606)Component
GO:0071285involved_in cellular response to lithium ion1IEAHomo_sapiens(9606)Process
GO:0071479involved_in cellular response to ionizing radiation1IGIHomo_sapiens(9606)Process
GO:0071897involved_in DNA biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0072089involved_in stem cell proliferation1IEAHomo_sapiens(9606)Process
GO:0075713involved_in establishment of integrated proviral latency1TASHomo_sapiens(9606)Process
GO:0097680involved_in double-strand break repair via classical nonhomologous end joining1IMPHomo_sapiens(9606)Process
GO:1904155involved_in DN2 thymocyte differentiation1IEAHomo_sapiens(9606)Process
GO:2001252involved_in positive regulation of chromosome organization1IMPHomo_sapiens(9606)Process

Expression