RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000174013	Gene ID	200933	Accession	29148
Symbol	FBXO45	Alias	Fbx45	Full Name	F-box protein 45
Status	Confidence	Length	20449 bases	Strand	Plus strand
Position	3 : 196568611 - 196589059	RNA binding domain	SPRY
Summary	Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000310332	SPRY	PF00622	7.8e-18	1
ENSP00000389868	SPRY	PF00622	6.7e-13	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
FBXO45-202	ENST00000440469	3689	107aa	ENSP00000389868
FBXO45-201	ENST00000311630	5927	286aa	ENSP00000310332

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
33033	Ankle Brachial Index	5.9973403E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001764	involved_in neuron migration	1	IEA	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	IEA	Homo_sapiens(9606)	Component
GO:0005634	located_in nucleus	1	IEA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IC	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0006974	involved_in DNA damage response	1	IDA	Homo_sapiens(9606)	Process
GO:0014069	located_in postsynaptic density	1	IEA	Homo_sapiens(9606)	Component
GO:0016567	involved_in protein ubiquitination	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0019005	part_of SCF ubiquitin ligase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0021799	involved_in cerebral cortex radially oriented cell migration	1	IEA	Homo_sapiens(9606)	Process
GO:0021800	involved_in cerebral cortex tangential migration	1	IEA	Homo_sapiens(9606)	Process
GO:0021957	involved_in corticospinal tract morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0021960	involved_in anterior commissure morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0042734	located_in presynaptic membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0042995	located_in cell projection	1	IEA	Homo_sapiens(9606)	Component
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0045202	is_active_in synapse	1	IBA	Homo_sapiens(9606)	Component
GO:0045211	located_in postsynaptic membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0060386	involved_in synapse assembly involved in innervation	1	IBA	Homo_sapiens(9606)	Process
GO:0070936	involved_in protein K48-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0098978	located_in glutamatergic synapse	1	IEA	Homo_sapiens(9606)	Component
GO:0099523	located_in presynaptic cytosol	1	IEA	Homo_sapiens(9606)	Component
GO:0099524	located_in postsynaptic cytosol	1	IEA	Homo_sapiens(9606)	Component
GO:1990756	enables ubiquitin ligase-substrate adaptor activity	1	IDA	Homo_sapiens(9606)	Function
GO:2000300	involved_in regulation of synaptic vesicle exocytosis	1	IEA	Homo_sapiens(9606)	Process