RBP Type
Canonical_RBPs
Diseases
N.A.
Drug
N.A.
Main interacting RNAs
diverse
Moonlighting functions
N.A.
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000173431 Gene ID
122665 Accession
19277
Symbol
RNASE8
Alias
RAE2
Full Name
ribonuclease A family member 8
Status
Confidence
Length
634 bases
Strand
Plus strand
Position
14 : 21057822 - 21058455
RNA binding domain
RnaseA
Summary
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000311398
RnaseA
PF00074 3.3e-37
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
RNASE8-201
ENST00000308227
634
154aa
ENSP00000311398
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
41711 Platelet Function Tests 1.5991650E-012 -
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000173431 homo_sapiens ENSP00000298690 84.6154 76.9231 homo_sapiens ENSP00000311398 85.7143 77.9221 ENSG00000173431 homo_sapiens ENSP00000512867 29.932 21.0884 homo_sapiens ENSP00000311398 28.5714 20.1299 ENSG00000173431 homo_sapiens ENSP00000302046 64.6667 54 homo_sapiens ENSP00000311398 62.987 52.5974 ENSG00000173431 homo_sapiens ENSP00000392996 28.2407 19.4444 homo_sapiens ENSP00000311398 39.6104 27.2727 ENSG00000173431 homo_sapiens ENSP00000451318 27.6382 14.5729 homo_sapiens ENSP00000311398 35.7143 18.8312 ENSG00000173431 homo_sapiens ENSP00000381077 37.415 26.5306 homo_sapiens ENSP00000311398 35.7143 25.3247 ENSG00000173431 homo_sapiens ENSP00000384683 24.2857 13.3333 homo_sapiens ENSP00000311398 33.1169 18.1818 ENSG00000173431 homo_sapiens ENSP00000381057 47.4359 35.2564 homo_sapiens ENSP00000311398 48.0519 35.7143 ENSG00000173431 homo_sapiens ENSP00000452245 43.5374 35.3741 homo_sapiens ENSP00000311398 41.5584 33.7662 ENSG00000173431 homo_sapiens ENSP00000372410 33.3333 19.8718 homo_sapiens ENSP00000311398 33.7662 20.1299 ENSG00000173431 homo_sapiens ENSP00000302324 50.625 37.5 homo_sapiens ENSP00000311398 52.5974 38.961 ENSG00000173431 homo_sapiens ENSP00000303276 54.6584 41.6149 homo_sapiens ENSP00000311398 57.1429 43.5065
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000173431 homo_sapiens ENSP00000311398 97.4026 96.7533 pan_paniscus ENSPPAP00000005423 96.7742 96.129 ENSG00000173431 homo_sapiens ENSP00000311398 93.5065 90.9091 pongo_abelii ENSPPYP00000006356 93.5065 90.9091 ENSG00000173431 homo_sapiens ENSP00000311398 98.0519 97.4026 pan_troglodytes ENSPTRP00000052805 96.1783 95.5414 ENSG00000173431 homo_sapiens ENSP00000311398 87.6623 83.7662 macaca_fascicularis ENSMFAP00000055512 75 71.6667 ENSG00000173431 homo_sapiens ENSP00000311398 75.3247 63.6364 ailuropoda_melanoleuca ENSAMEP00000021108 74.359 62.8205 ENSG00000173431 homo_sapiens ENSP00000311398 81.8182 70.1299 bos_indicus_hybrid ENSBIXP00005016340 80.7692 69.2308 ENSG00000173431 homo_sapiens ENSP00000311398 76.6234 66.8831 oryctolagus_cuniculus ENSOCUP00000000566 75.641 66.0256 ENSG00000173431 homo_sapiens ENSP00000311398 82.4675 72.0779 marmota_marmota_marmota ENSMMMP00000016773 77.9141 68.0982 ENSG00000173431 homo_sapiens ENSP00000311398 81.1688 67.5325 balaenoptera_musculus ENSBMSP00010012592 80.1282 66.6667 ENSG00000173431 homo_sapiens ENSP00000311398 68.1818 55.1948 felis_catus ENSFCAP00000036512 67.3077 54.4872 ENSG00000173431 homo_sapiens ENSP00000311398 57.1429 46.1039 ursus_americanus ENSUAMP00000013810 53.6585 43.2927 ENSG00000173431 homo_sapiens ENSP00000311398 82.4675 70.1299 bison_bison_bison ENSBBBP00000001858 81.4103 69.2308 ENSG00000173431 homo_sapiens ENSP00000311398 81.1688 68.8312 monodon_monoceros ENSMMNP00015013103 80.1282 67.9487 ENSG00000173431 homo_sapiens ENSP00000311398 81.8182 72.0779 sus_scrofa ENSSSCP00000023687 80.7692 71.1538 ENSG00000173431 homo_sapiens ENSP00000311398 81.1688 68.8312 ovis_aries_rambouillet ENSOARP00020019451 80.1282 67.9487 ENSG00000173431 homo_sapiens ENSP00000311398 68.8312 55.8442 delphinapterus_leucas ENSDLEP00000002491 37.4558 30.3887 ENSG00000173431 homo_sapiens ENSP00000311398 86.3636 79.2208 aotus_nancymaae ENSANAP00000001185 85.8064 78.7097 ENSG00000173431 homo_sapiens ENSP00000311398 84.4156 80.5195 saimiri_boliviensis_boliviensis ENSSBOP00000038580 71.8232 68.5083 ENSG00000173431 homo_sapiens ENSP00000311398 70.7792 60.3896 vicugna_pacos ENSVPAP00000004837 71.2418 60.7843 ENSG00000173431 homo_sapiens ENSP00000311398 91.5584 88.961 chlorocebus_sabaeus ENSCSAP00000017658 91.5584 88.961 ENSG00000173431 homo_sapiens ENSP00000311398 78.5714 70.1299 tupaia_belangeri ENSTBEP00000004445 78.0645 69.6774 ENSG00000173431 homo_sapiens ENSP00000311398 77.9221 70.7792 camelus_dromedarius ENSCDRP00005003189 76.9231 69.8718 ENSG00000173431 homo_sapiens ENSP00000311398 73.3766 61.039 carlito_syrichta ENSTSYP00000008894 81.295 67.6259 ENSG00000173431 homo_sapiens ENSP00000311398 81.8182 74.6753 prolemur_simus ENSPSMP00000017368 80.2548 73.2484 ENSG00000173431 homo_sapiens ENSP00000311398 81.8182 70.1299 bos_mutus ENSBMUP00000025452 80.7692 69.2308 ENSG00000173431 homo_sapiens ENSP00000311398 82.4675 70.7792 rhinolophus_ferrumequinum ENSRFEP00010026965 81.4103 69.8718 ENSG00000173431 homo_sapiens ENSP00000311398 92.8571 88.961 rhinopithecus_bieti ENSRBIP00000021216 92.8571 88.961 ENSG00000173431 homo_sapiens ENSP00000311398 50 45.4545 sciurus_vulgaris ENSSVLP00005001691 75.4902 68.6274 ENSG00000173431 homo_sapiens ENSP00000311398 82.4675 74.6753 sciurus_vulgaris ENSSVLP00005001702 81.9355 74.1936 ENSG00000173431 homo_sapiens ENSP00000311398 81.1688 68.8312 cervus_hanglu_yarkandensis ENSCHYP00000020091 80.1282 67.9487 ENSG00000173431 homo_sapiens ENSP00000311398 78.5714 68.8312 catagonus_wagneri ENSCWAP00000008240 77.5641 67.9487 ENSG00000173431 homo_sapiens ENSP00000311398 84.4156 75.3247 ictidomys_tridecemlineatus ENSSTOP00000019320 83.3333 74.359 ENSG00000173431 homo_sapiens ENSP00000311398 83.1169 75.974 otolemur_garnettii ENSOGAP00000001024 81.0127 74.0506 ENSG00000173431 homo_sapiens ENSP00000311398 77.2727 68.1818 urocitellus_parryii ENSUPAP00010002381 72.1212 63.6364 ENSG00000173431 homo_sapiens ENSP00000311398 81.8182 73.3766 urocitellus_parryii ENSUPAP00010002590 82.3529 73.8562 ENSG00000173431 homo_sapiens ENSP00000311398 80.5195 66.8831 moschus_moschiferus ENSMMSP00000010911 79.4872 66.0256 ENSG00000173431 homo_sapiens ENSP00000311398 92.8571 88.961 rhinopithecus_roxellana ENSRROP00000006656 92.8571 88.961
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0003676 enables nucleic acid binding 1 IEA Homo_sapiens(9606) Function GO:0004522 enables ribonuclease A activity 1 IDA Homo_sapiens(9606) Function GO:0004540 enables RNA nuclease activity 1 IBA Homo_sapiens(9606) Function GO:0005615 is_active_in extracellular space 1 IBA Homo_sapiens(9606) Component GO:0045087 involved_in innate immune response 2 IBA,IMP Homo_sapiens(9606) Process GO:0050829 involved_in defense response to Gram-negative bacterium 3 IBA,IDA,IMP Homo_sapiens(9606) Process GO:0050830 involved_in defense response to Gram-positive bacterium 2 IBA,IDA Homo_sapiens(9606) Process GO:0050832 involved_in defense response to fungus 1 IBA Homo_sapiens(9606) Process GO:0061760 involved_in antifungal innate immune response 1 IDA Homo_sapiens(9606) Process
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