RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Description

Ensembl ID	ENSG00000173200	Gene ID	165631	Accession	26876
Symbol	PARP15	Alias	BAL3;ARTD7;pART7	Full Name	poly(ADP-ribose) polymerase family member 15
Status	Confidence	Length	61420 bases	Strand	Plus strand
Position	3 : 122577628 - 122639047	RNA binding domain	PARP
Summary	Enables NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II; protein mono-ADP-ribosylation; and protein poly-ADP-ribosylation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000419488	PARP	PF00644	5.7e-26	1
ENSP00000308436	PARP	PF00644	7.3e-26	1
ENSP00000417785	PARP	PF00644	9.2e-26	1
ENSP00000417214	PARP	PF00644	1.9e-25	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
37326024	Updated protein domain annotation of the PARP protein family sheds new light on biological function.	J Marcin Suskiewicz	2023-08-25	Nucleic acids research

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
PARP15-205	ENST00000483793	4439	483aa	ENSP00000417785
PARP15-202	ENST00000464300	5002	678aa	ENSP00000417214
PARP15-203	ENST00000465304	1987	No protein	-
PARP15-201	ENST00000310366	1518	444aa	ENSP00000308436
PARP15-206	ENST00000493645	1311	375aa	ENSP00000419488
PARP15-204	ENST00000473627	559	No protein	-

Gene Model

Click here to download ENSG00000173200's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
2795	Diabetes Mellitus	1.7792626E-6	17903298
68234	Electrocardiography	1E-6	20031603
78885	Periodontitis	3E-6	24024966
104001	Depressive Disorder	6E-6	22472876

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000173200's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IMP	Homo_sapiens(9606)	Process
GO:0003714	enables transcription corepressor activity	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0003950	enables NAD+ ADP-ribosyltransferase activity	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IC	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0010629	involved_in negative regulation of gene expression	1	IBA	Homo_sapiens(9606)	Process
GO:0016779	enables nucleotidyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0070212	involved_in protein poly-ADP-ribosylation	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0070403	enables NAD+ binding	1	IMP	Homo_sapiens(9606)	Function
GO:1990404	enables NAD+-protein ADP-ribosyltransferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function

Expression